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Metabolite of (-)-trans-delta 8-tetrahydrocannabinol: identification and synthesis |
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| Authors: | R L Foltz A F Fentiman F G Leighty J L Walter H R Drewes W E Schwartz T F Page E B Truitt |
| Abstract: | The major metabolite of (-)-trans-Delta(8)-tetrahydrocannabinol observed in vivo and formed by hepatic microsomes in vitro is 11-hydroxy-trans-Delta(8)-tetrahydrocannabinol. The metabolite was identified spectroscopically and was synthesized from trans-Delta(8)-tetrahydrocannabinol. In tests with rats, the metabolite produced behavioral effects similar to those imparted by Delta(8)- and Delta(9)-tetrahydrocannabinol. |
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