Disposition kinetics and urinary excretion of ciprofloxacin in goats following single intravenous administration |
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| Authors: | R. Raina S. Prawez D.J. Dimitrova N.K. Pankaj P.K. Verma |
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| Affiliation: | 1Division of Pharmacology and Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, She-e-Kasmir University of Agricultural Sciences and Technology of Jammu, Jammu 181102, India.;2Department of Pharmacology, Toxicology and Therapeutics, Faculty of Veterinary Medicine, Trakia University, Stara Zagora, Bulgaria. |
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| Abstract: | We evaluated the pharmacokinetics of ciprofloxacin in serum (n = 6) and urine (n = 4) in goats following a single intravenous administration of 4 mg/kg body weight. The serum concentration-time curves of ciprofloxacin were best fitted by a two-compartment open model. The drug was detected in goat serum up to 12 h. The elimination rate constant (β) and elimination half-life (t1/2β) were 0.446 ± 0.04 h-1 and 1.630 ± 0.17 h, respectively. The apparent volume of distribution at steady state (Vdss) was 2.012 ± 0.37 l/kg and the total body clearance (ClB) was 16.27 ± 1.87 ml/min/kg. Urinary recovery of ciprofloxacin was 29.70% ± 10.34% of the administered dose within 36 h post administration. In vitro serum protein binding was 41% ± 13.10%. Thus, a single daily intravenous dose of 4 mg/kg is sufficient to maintain effective levels in serum and for 36 h in urine, allowing treatment of systemic, Gram-negative bacterial infections and urinary tract infections by most pathogens. |
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| Keywords: | ciprofloxacin disposition kinetics goat urinary excretion |
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