A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis |
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| Authors: | J M Ribeiro A Vachereau G B Modi R B Tesh |
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| Affiliation: | Department of Tropical Public Health, Harvard School of Public Health, Boston, MA 02115. |
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| Abstract: | Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide. |
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