草珊瑚注射液稳定性试验研究

黄酮类化合物是草珊瑚注射液中含量最多、最主要的有效成分。研究表明,草珊瑚注射液中总黄酮含量在存放3年中平均每年降低0.86%;在加热灭菌后降低0.82%,变化甚微,是非常稳定的。强光直射30 h可使注射液中总黄酮含量平均下降9.91%,影响较大。注射液的pH值在4~6时总黄酮含量最高。在温度、时间、pH值对注射液稳定性影响中,以pH值变化影响较大。灭菌后注射液pH值平均降低0.67,3年存放中平均每年降低0.16%。在8种常用注射液的附加剂中以硫代硫酸钠,亚硫酸钠对总黄酮的稳定性影响较大,使总黄酮含量降低21.98%~12.07%。在与26种中草药注射液的配伍中,与博落回、苦参、黄柏、虎仗、朱砂莲、地苦胆、十大功劳有配伍禁忌。

Studies on the Stability of Sarcandrae glabra Injection

The flavonoids are important and main compositions in the injection of Sarcandrae glabra. The research results show that the flavonoids in the injection are decreased 0.86 % annually in three years and lowered 0.82 % after being disinfected. The strong light shooting for 30 hours can make the flavonoids descend average 9.91%. The flavonoids in the injection are the highest in pH 4-6. In the factors to influence stability of the injection, pH influenced bigger than other factors include temperature, time and pH value, pH value in the injection is averagely lowered 0.67% after being sterilized and lowered 0.16% annually after being stored three years. In the additives for the eight kinds com mon injections, sodium thiosulphate and sodium sulfate made the sterilized stability of the flavonoids descent 21.98 % - 12.07 %. In mixture with 26 kinds different injections made from traditional Chinese herbal medicine, it is not viable for Sarcandrae glabra to mix with Macleya cordata, Sophora flavescens, Phellodendron chinense , Polygonum cuspidatum , Aristolochia tuberose, Tinospora capillipes Gagnep , Mahonia japonica.