Vaccination of cattle with Mycoplasma bovoculi antigens: evidence for field immunity |
| |
| Authors: | B A Salih A G Ostle R F Rosenbusch |
| |
| Institution: | 1. Division of Data Analysis and Statistics, DTU Compute, Technical University of Denmark, Building 324, DK-2800 Kgs. Lyngby, Denmark;2. Division of Risk Assessment and Nutrition, The National Food Institute, Technical University of Denmark, Mørkhøj Bygade 19, DK-2860 Søborg, Denmark;3. Zoonotic Infections of People, Pigs and Poultry Group, Department of Epidemiology and Population Health, Institute of Infection and Global Health, Leahurst Campus, University of Liverpool, Neston CH64 7TE, UK;4. Centre de Recerca en Sanitat Animal (CReSA), IRTA, Campus de la Universitat Autònoma de Barcelona, 08193-Bellaterra (Cerdanyola del Vallès), Barcelona, Spain;5. Department of Hygiene of Food of Animal Origin, National Veterinary Research Instiute, Partyzantow 57, 24-100 Pulawy, Poland;6. Norwegian Veterinary Institute, Pb 750 Sentrum, N-0106 Oslo, Norway;7. Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, PO Box 80.165, 3508 TD Utrecht, The Netherlands |
| |
| Abstract: | Cattle previously exposed to Mycoplasma bovoculi developed a high serum IgG and cellular responses detected by ELISA and lymphocyte blastogenesis respectively, when immunized with three M. bovoculi antigen preparations (two non-ionic detergent extracts and a killed whole organism). Similar responses to the detergent immunogen were observed in colostrum-deprived calves free of M. bovoculi. Following ocular challenge with live M. bovoculi all animals including the control group cleared the organism. However the organism colonized the eyes of the colostrum-deprived calves. These observations indicate that previous exposure to M. bovoculi confers immunity to reinfection and that none of the vaccines provided a protective activity against the organism. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
