Critical roles for Rac1 and Rac2 GTPases in B cell development and signaling |
| |
Authors: | Walmsley Marita J Ooi Steen K T Reynolds Lucinda F Smith Susan Harless Ruf Sandra Mathiot Anne Vanes Lesley Williams David A Cancro Michael P Tybulewicz Victor L J |
| |
Institution: | Division of Immune Cell Biology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK. |
| |
Abstract: | The Rac1 guanosine triphosphatase (GTPase) has been implicated in multiple cellular functions, including actin dynamics, proliferation, apoptosis, adhesion, and migration resulting from signaling by multiple receptors, including the B cell antigen receptor (BCR). We used conditional gene targeting to generate mice with specific Rac1 deficiency in the B cell lineage. In the absence of both Rac1 and the highly related Rac2, B cell development was almost completely blocked. Both GTPases were required to transduce BCR signals leading to proliferation, survival and up-regulation of BAFF-R, a receptor for BAFF, a key survival molecule required for B cell development and maintenance. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|