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Radioreceptor assay of adrenocorticotropic hormone: new approach to assay of polypeptide hormones in plasma |
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| Authors: | R J Lefkowitz J Roth I Pastan |
| Abstract: | Biologically active iodine-125-labeled adrenocorticotropic hormone (ACTH) binds specifically to ACTH receptors extracted from adrenals. Unlabeled ACTH at 1 picogram per milliliter significantly displaces labeled ACTH from these receptors. This system, which appears to be applicable to all polypeptide hormones, provides a rapid and sensitive method for measurements of biologically active ACTH in dilute whole plasma. |
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