| 对氯苯丙酮肟衍生物的合成及其生物活性 |
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| 引用本文： | 王远光,袁莉萍,陈亮,曹瑾,郭庆铭,张一宾. 对氯苯丙酮肟衍生物的合成及其生物活性[J]. 农药学学报, 2005, 7(2): 114-118 |
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| 作者姓名： | 王远光 袁莉萍 陈亮 曹瑾 郭庆铭 张一宾 |
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| 作者单位： | 华东理工大学,化学与制药学院,上海,200237;上海市农药研究所,上海,200032 |
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| 基金项目： | 国家“十五”科技攻关计划(2004BA308A223)，上海市科技攻关计划(034319251)，国家重点基础研究计划(973计划)(2003CB114401). |
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| 摘 要： | 为寻找新型结构的农药先导化合物,采用1-对氯苯基-3-氯-1-丙酮为原料,合成了14个结构新颖的对氯苯丙酮肟衍生物,其化学结构经1H核磁共振和元素分析确证。初步的生物活性试验结果表明,该类化合物具有一定的杀虫和除草活性,其中化合物 Ⅴi、Ⅴe和Ⅴh 在 50 mg/L浓度下对淡色库蚊Culex pipiens pallens的致死率达到100%。
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| 关 键 词： | 对氯苯丙酮肟 合成 生物活性 |
| 文章编号： | 1008-7303(2005)02-0114-05 |
| 收稿时间： | 2004-12-30 |
| 修稿时间： | 2004-12-30 |
Synthesis and Bioactivity of1--propan-1-one-oxime Derivatives |
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| WANG Yuan-guang,YUAN Li-ping,CHEN Liang,CAO Jin,GUO Qing-ming and ZHANG Yi-bin. Synthesis and Bioactivity of1--propan-1-one-oxime Derivatives[J]. Chinese Journal of Pesticide Science, 2005, 7(2): 114-118 |
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| Authors: | WANG Yuan-guang YUAN Li-ping CHEN Liang CAO Jin GUO Qing-ming ZHANG Yi-bin |
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| Affiliation: | 1.East China University of Science and Technology, Chemical and Pharmaceutical Institute, Shanghai 200237, China2.Shanghai Pesticide Research Institute, Shanghai 200032, China |
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| Abstract: | In search of pesticide leading compound with new type of structure, fourteen novel 1-(4-chlorophenyl) propan-1-one oxime derivates were designed and synthesized. Their structures were confirmed by 1H NMR and elemental analysis. The preliminary bioassay showed that this kind of compounds presented insecticidal and herbicidal activities. The mortality of Ⅴi, Ⅴe and Ⅴh to Culex pipiens pallens at the concentration of 50 mg/L reached 100%. |
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| Keywords: | 1-(4-chlorophenyl)-propan-1-one oxime synthesis bioactivity [HJ*5/9] |
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