Somatostatin augments the M-current in hippocampal neurons |
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Authors: | S D Moore S G Madamba M Jo?ls G R Siggins |
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Affiliation: | Research Institute of Scripps Clinic, La Jolla, CA 92037. |
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Abstract: | Immunocytochemical and electrophysiological evidence suggests that somatostatin may be a transmitter in the hippocampus. To characterize the ionic mechanisms underlying somatostatin effects, voltage-clamp and current-clamp studies on single CA1 pyramidal neurons in the hippocampal slice preparation were performed. Both somatostatin-28 and somatostatin-14 elicited a steady outward current and selectively augmented the noninactivating, voltage-dependent outward potassium current known as the M-current. Since the muscarinic cholinergic agonists carbachol and muscarine antagonized this current, these results suggest a reciprocal regulation of the M-current by somatostatin and acetylcholine. |
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