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Sequencing of Culex quinquefasciatus establishes a platform for mosquito comparative genomics
Authors:Arensburger Peter  Megy Karine  Waterhouse Robert M  Abrudan Jenica  Amedeo Paolo  Antelo Beatriz  Bartholomay Lyric  Bidwell Shelby  Caler Elisabet  Camara Francisco  Campbell Corey L  Campbell Kathryn S  Casola Claudio  Castro Marta T  Chandramouliswaran Ishwar  Chapman Sinéad B  Christley Scott  Costas Javier  Eisenstadt Eric  Feschotte Cedric  Fraser-Liggett Claire  Guigo Roderic  Haas Brian  Hammond Martin  Hansson Bill S  Hemingway Janet  Hill Sharon R  Howarth Clint  Ignell Rickard  Kennedy Ryan C  Kodira Chinnappa D  Lobo Neil F  Mao Chunhong  Mayhew George  Michel Kristin  Mori Akio  Liu Nannan  Naveira Horacio
Institution:Center for Disease Vector Research, University of California Riverside, Riverside, CA 92521, USA. arensburger@gmail.com
Abstract:Culex quinquefasciatus (the southern house mosquito) is an important mosquito vector of viruses such as West Nile virus and St. Louis encephalitis virus, as well as of nematodes that cause lymphatic filariasis. C. quinquefasciatus is one species within the Culex pipiens species complex and can be found throughout tropical and temperate climates of the world. The ability of C. quinquefasciatus to take blood meals from birds, livestock, and humans contributes to its ability to vector pathogens between species. Here, we describe the genomic sequence of C. quinquefasciatus: Its repertoire of 18,883 protein-coding genes is 22% larger than that of Aedes aegypti and 52% larger than that of Anopheles gambiae with multiple gene-family expansions, including olfactory and gustatory receptors, salivary gland genes, and genes associated with xenobiotic detoxification.
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