Present Concepts on the Inflammatory Modulators with Special Reference to Cytokines* |
| |
Authors: | Van Miert ASJPAM |
| |
Institution: | (1) Department of Veterinary Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Utrecht University, PO Box 80152, NL 3508 TD Utrecht, The Netherlands |
| |
Abstract: | The pro- and anti-inflammatory cytokines create a network of interactions between cells that lead to both stimulatory and inhibitory responses that maintain an effective homeostatic regulation. The anti-inflammatory cytokines are a family of peptides that modulate the pro-inflammatory cytokine response. Cytokines act in concert with non-cytokine mediators, such as prostaglandin E2, glucocorticosteroids, lipocortins, and catecholamines. This review highlights new developments in our understanding of the pathophysiology of inflammation and gives an example of a more recent approach to the modulation of acute systemic inflammatory disorders: activation of 2-adrenergic receptors on macrophages. In this respect the potent 2-adrenergic agonist clenbuterol seems of therapeutic interest. |
| |
Keywords: | acute-phase response 2-adrenergic receptors" target="_blank">gif" alt="beta" align="MIDDLE" BORDER="0">2-adrenergic receptors catecholamines clenbuterol cytokines glucocorticosteroids inflammation lipocortin-1 peptides prostaglandins |
本文献已被 PubMed SpringerLink 等数据库收录! |
|