Direct coupling between meiotic DNA replication and recombination initiation |
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Authors: | Borde V Goldman A S Lichten M |
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Institution: | Laboratory of Biochemistry, Division of Basic Science, National Cancer Institute, Bethesda, MD 20892-4255, USA. |
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Abstract: | During meiosis in Saccharomyces cerevisiae, DNA replication occurs 1. 5 to 2 hours before recombination initiates by DNA double-strand break formation. We show that replication and recombination initiation are directly linked. Blocking meiotic replication prevented double-strand break formation in a replication-checkpoint-independent manner, and delaying replication of a chromosome segment specifically delayed break formation in that segment. Consequently, the time between replication and break formation was held constant in all regions. We suggest that double-strand break formation occurs as part of a process initiated by DNA replication, which thus determines when meiotic recombination initiates on a regional rather than a cell-wide basis. |
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