2,3,7,8-Tetrachlorodibenzo-p-dioxin influences bovine herpesvirus 1 replication through upregulation of SIRT3 and cytoskeletal reorganization |
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| Authors: | Filomena Fiorito Valentina Iovane Annarosaria Marullo Anna Costagliola Giovanna Elvira Granato Luisa De Martino |
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| Institution: | 1.Istituto Zooprofilattico Sperimentale del Mezzogiorno,Portici,Italy;2.Department of Pharmacy,University of Salerno,Fisciano,Italy;3.Department of Veterinary Medicine and Animal Production,University of Naples “Federico II”,Naples,Italy;4.Department of Veterinary Medical Sciences, Alma Mater Studiorum,University of Bologna,Bologna,Italy |
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| Abstract: | Infection of kidney cells (MDBK) with Bovine Herpesvirus 1 (BoHV-1) is affected by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which accelerates BoHV-1-induced apoptosis and increases virus replication. Herein, to elucidate the mechanism through TCDD modifies BoHV-1 infection, we analyzed the modulation of a members of Sirtuin proteins family in MDBK cells. We found that mitochondrial SIRT3 was upregulated during infection. This change was accompanied by cytoskeletal rearrangements and cell extensions. All these trends were drastically modified by TCDD. We hypothesize that, taken together, these results might further clarify the processes responsible for the action of TCDD on the BoHV-1 replication, resulting in enhanced virus production. |
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