| 测定鸡传染性法氏囊病活疫苗（B87株）参考品有效期的经典热加速稳定试验 |
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| 引用本文： | 李翠,王在时. 测定鸡传染性法氏囊病活疫苗（B87株）参考品有效期的经典热加速稳定试验[J]. 中国兽药杂志, 2014, 48(2): 11-13 |
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| 作者姓名： | 李翠 王在时 |
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| 作者单位： | 中国兽医药品监察所,中国兽医药品监察所 |
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| 基金项目： | “十一五”科技支撑计划（2006BAD06A10） |
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| 摘 要： | 采用热加速稳定性试验，以鸡胚半数致死量测定法对制备的参考疫苗进行病毒含量测定，预期其贮存有效期。根据Arrhenius方程，以不同温度下衰减速率常数K估算较低温度下K值，并计算参考疫苗在-30℃下贮存效力值下降一个滴度所需的时间约为2．4年。
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| 关 键 词： | 鸡传染性法氏囊病活疫苗（B87株） 热加速稳定性试验 有效期 |
| 收稿时间： | 2013-08-19 |
| 修稿时间： | 2013-12-18 |
Accelerated Thermostability Test of Living Infectious Bursal Disease Vaccine (B87 Strain) |
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| LI Cui,GUO Cai-yun,DAI Zhi-hong,JIANG Hui,ZHANG Xiu-ying,WEN Fang,LU Lian-shou,WANG Zai-shi. Accelerated Thermostability Test of Living Infectious Bursal Disease Vaccine (B87 Strain)[J]. Chinese Journal of Veterinary Drug, 2014, 48(2): 11-13 |
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| Authors: | LI Cui GUO Cai-yun DAI Zhi-hong JIANG Hui ZHANG Xiu-ying WEN Fang LU Lian-shou WANG Zai-shi |
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| Affiliation: | China Institude of Veterinary Drug Control, |
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| Abstract: | Accelerated thermostability test was used to evaluate the valid storage period of living infectious bursal disease vaccine （ B87 strain） with kinetic analysis of the amount of virus of the vaccine （ELDso）. K parameter of lower temperature was estimated from K parameter of higher temperature. And the validity of the vaccine stored at -30℃ would be about 2.4 years, calculated from the K parameter. Results of continuous stability monitoring for one year were in accordance with that expected by the accelerated thermostability test. |
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| Keywords: | infectious bursal disease living vaccine （B87 strain） accelerated thermostability test valid period |
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