| Institution: | 1. Postgraduate Program in Health and Development in the Midwest Region, Faculty of Medicine (FAMED), Federal University of Mato Grosso do Sul (UFMS), Campo Grande – MS, Brazil;2. Protein Purification Laboratory and its Biological Functions (LPPFB), Federal University of Mato Grosso do Sul (UFMS), Campo Grande – MS, Brazil;3. Faculty of Pharmaceutical Sciences, Food, and Nutrition (FACFAN), Federal University of Mato Grosso do Sul (UFMS), Campo Grande – MS, Brazil;4. Faculty of Biological and Health Sciences, University Center of Grande Dourados (UNIGRAN), Dourados – MS, Brazil;5. Faculty of Biological and Health Sciences, University Center of Grande Dourados (UNIGRAN), Dourados – MS, Brazil
Clinical analysis laboratory, University Center of Grande Dourados (UNIGRAN), Dourados – MS, Brazil;6. Faculty of Medicine, Federal University of Mato Grosso do Sul (UFMS), Campo Grande – MS, Brazil;7. Bioscience Institute (INBIO), Federal University of Mato Grosso do Sul (UFMS), Campo Grande – MS, Brazil;8. Institute of Chemistry (INQUI), Federal University of Mato Grosso do Sul (UFMS), Campo Grande – MS, Brazil |
| Abstract: | Metabolic syndrome (MetS) and obesity are growing in many parts of the world, becoming public health problems. It is proposed that foods with functional properties can assist in the treatment of these diseases. Crude buriti pulp oil (BPO) is a food traditionally consumed by residents in the Pantanal, Cerrado and Brazilian Amazon. It is rich in oleic acid, tocopherols and carotenoids, emerging as a potential functional food. Thus, this study aimed to evaluate the effect of the supplementation of BPO on metabolic disorders caused by a high-fat diet. Four groups of C57BL6 mice were used, a lean group with AIN-93M diet and control oil supplementation, an obese group with a high-fat diet and control oil supplementation, and two obese groups with a high-fat diet and BPO supplementation in the amounts of 50 and 100 mg/kg. BPO worsened the metabolic state caused by the high-fat diet, worsening risk factors associated with MetS, as the abdominal circumference and retroperitoneal fat, serum levels of total cholesterol, uric acid, alanine transaminase, glucose and triglycerides, and renal fat, in addition to changes in glycaemic control and oxidative stress markers. C57BL/6 mice fed with a high-fat diet and supplemented with BPO presented a worsening in metabolic risk factors associated with MetS. |
