Immunology. Therapeutic manipulation of gut flora |
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Authors: | Shanahan F |
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Affiliation: | Department of Medicine, Cork University Hospital, Cork, Ireland. fshanahan@ucc.ie |
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Abstract: | In developed countries as many as two individuals in every thousand suffer from inflammatory bowel disease (ulcerative colitis and Crohn's disease). In his Perspective, Shanahan discusses a new therapeutic approach to treating these conditions in which bacteria normally found in the gut are engineered to produce the anti-inflammatory cytokine interleukin-10 and then are fed as probiotics to mice with these disorders (Steidler et al.). |
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