戊唑醇硅酸钙纳米胶囊缓释剂的制备及其缓释性能研究

以正硅酸乙酯(TEOS)和氯化钙为壁材固化包裹戊唑醇,制备得到2.5%的戊唑醇硅酸钙纳米胶囊缓释剂.并利用扫描电镜、激光粒度分布仪、傅里叶红外色谱仪、高效液相色谱对其理化性能进行详细表征,并对其缓释性能进行了探讨.结果表明:该方法能够得到硅酸钙包裹的戊唑醇纳米胶囊缓释剂;胶囊形状为规则的球形,平均粒径为209.8nm,粒径分布窄,且呈正态分布,形态稳定;较高温度和pH碱性能够提升戊唑醇的缓释速率,壁材的增厚会降低戊唑醇的缓释速率.戊唑醇微胶囊的制备对提高戊唑醇的使用效率、降低残留、减少环境污染具有重要的意义.

Preparation of Tebuconazole Nano-Capsule Incorporating CaSiO3 and Study of Its Controlled Release Performance

In this study,2.5% tebuconazole sustained-release capsule agent was prepared via the method of CaSiO3 package curing tebuconazole,using tetraethyl orthosilicate (TEOS) and calcium chloride as the wall materials. The particle size range,physical behavior and sustained-release properties of the product were characterized by scanning electron microscopy (SEM),laser particle size distribution instrument,Fourier transform infrared spectroscopy (FTIR) and high performance liquid chromatography (HPLC). The results showed that the preparation method of tebuconazole capsule enclosed by calcium silicate was practicable. This capsule was regularly spherical in shape,with an average particle size of 209.8 nm,and narrowly and normally distributed with shape stability. Moreover,high temperature,alkaline pH as well as thin wall materials could enhance the release speed of tebuconazole. Therefore,tebuconazole micro-capsule preparation can be of important significance for improving the effective usage of tebuconazole,residue reduction and environment pollution reduction.