| 豆类丝核菌次级代谢产物对肿瘤细胞超微结构的影响 |
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| 引用本文： | 张 黎,杨鸣琦.豆类丝核菌次级代谢产物对肿瘤细胞超微结构的影响[J].中国农学通报,2005,21(7):7-7. |
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| 作者姓名： | 张 黎 杨鸣琦 |
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| 作者单位： | 西北农林科技大学动物科技学院,陕西,杨凌,712100 |
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| 基金项目： | 国家自然科学基金资助项目(30270979)和陕西省自然科学基金资助项目(2003C119)资助. |
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| 摘 要： | 通过建立种植性肝癌（H22）实体瘤动物模型，并给荷瘤小鼠灌胃含有苦马豆素（swainsonine, SW）且剂量分别为2.7 mg/(kg·d)和16.2 mg/(kg·d)的豆类丝核菌次级代谢产物稀释液，于灌药后16 d剖检荷瘤动物并取肿瘤组织与肝组织制作超薄切片,透射电镜观察。结果表明，该次级代谢产物能抑制种植性实体瘤（H22）的生长和转移。因此，该次级代谢产物具有抗肿瘤药用价值。
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| 关 键 词： | 豆类丝核菌 苦马豆素 次级代谢产物 肿瘤 H22 |
| 修稿时间： | 2005年1月26日 |
Effects of Secondary Metabolites of Rhizoctonia Leguminicola on Hepatoma 22 cells were observed by TEM |
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| Zhang Li,Yang Mingqi.Effects of Secondary Metabolites of Rhizoctonia Leguminicola on Hepatoma 22 cells were observed by TEM[J].Chinese Agricultural Science Bulletin,2005,21(7):7-7. |
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| Authors: | Zhang Li Yang Mingqi |
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| Institution: | (College of Animal Science and Technology, Northwest Sci-Tech University of Agriculture and Forestry, YangLing Shaanxi 712100) |
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| Abstract: | During the study, we built cancer mold by transplanting Hepatoma 22 cells to rats, and pour the secondary metabolites of Rhizoctonia Leguminicola which have swainsonine into the stomach of the rats, and the doses of swainsonine are 2.7 mg·kg-1·d-1 and 16.2 mg·kg-1·d-1 separately. The pathology changes were observed by TEM. The result shows that the secondary metabolites can inhibit tumor growth and metastasis. Above all, the secondary metabolites of Rhizoctonia Leguminicola have similar function with swainsonine. And they have value as antitumor drugs. |
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| Keywords: | Rhizoctonia Leguminicola Swainsonine Secondary metabolites Tumour H_(22) |
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