Heritability of syringomyelia in Cavalier King Charles spaniels |
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| Authors: | Tom Lewis Clare Rusbridge Penny Knowler Sarah Blott John A Woolliams |
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| Institution: | 1. Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU, UK;2. Stone Lion Veterinary Hospital, Wimbledon, London SW19 5AW, UK;3. Roslin Institute, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin, Midlothian EH25 9PS, UK;1. Department of Veterinary Clinical Sciences, Neurology and Neurosurgery, Royal Veterinary College, Hatfield AL9 7TA, UK;2. Department of Veterinary Clinical Sciences, Small Animal Clinic, Justus-Liebig-University, Frankfurter Straße 108, 35392 Giessen, Germany;1. Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easterbush, Roslin, Mid-Lothian, Scotland, EH25 9RG, UK;2. School of Veterinary Medicine, The University of Glasgow, Garscube Campus, Bearsden Road, Glasgow, Scotland, G61 1QH, UK;1. Department of Animal Biosciences, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada;2. Campbell Centre for the Study of Animal Welfare, University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada;1. Bristol Veterinary School, University of Bristol, Langford House, Langford, BS40 5DU, UK;2. School of Veterinary Medicine, University of Surrey, Guildford, GU2 7AL, UK;3. Fitzpatrick Referrals, Halfway Lane, Eashing, Surrey, GU7 2QQ, UK;4. Dog Breeding Reform Group, Wotton-under-Edge, GL12 7AX, UK |
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| Abstract: | Mixed model analysis of 384 Cavalier King Charles spaniels (CKCS), with a magnetic resonance imaging diagnosis for the presence or absence of a syrinx, in conjunction with the Kennel Club pedigree records of all dogs registered from the mid 1980s to September 2007, revealed a moderately high estimate of heritability of syringomyelia (h2 = 0.37 ± 0.15 standard error) when analysed as a binary trait. Inspection of cases where the disease segregated within families pointed to genes at more than one locus influencing syringomyelia. The availability of estimated breeding values for Kennel Club registered CKCS is a significant step in being able to select against syringomyelia, particularly given the difficulty of ascertaining the disease phenotype. |
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