The genus Hypericum--a valuable resource of anti-Staphylococcal leads |
| |
Authors: | Gibbons Simon Ohlendorf Birgit Johnsen Inga |
| |
Institution: | Centre for Pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK. simon.gibbons@ulsop.ac.uk |
| |
Abstract: | In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 microg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|