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Hiromi Takahashi Chieko Kai Yasuhiro Yoshikawa Kazuya Yamanouchi 《Comparative immunology, microbiology and infectious diseases》1995,18(4):275-281
Pseudorabies virus (PRV) was inoculated intraocularly into BALB/c mice, and the distribution pattern of cells positive for several neurotransmitters and viral antigens in the eyeball, trigeminal nerve ganglia, and superior cervical ganglia was examined immunohistochemically to clarify the neural route of the virus spread. In the eyeball, substance P (SP)- and calcitonin gene-related peptide (CGRP)-positive cells were detected in the ipsilateral iris and ciliary body, neuropeptide tyrosine (NPY)-positive cells were detected in the choloid membrane, and tyrosine hydroxylase (TH)-positive cells were detected in the ipsilateral inner nuclear layer of the retina; all these cells contained viral antigens. In the superior cervical ganglia, viral antigen-positive cells containing TH or NPY were found at bilateral sites. In the trigeminal nerve ganglia, viral antigen-positive cells containing SP or CGRP were found at bilateral sites. These findings indicated that the SP- and CGRP-positive ganglion cells of the trigeminal nerve ganglia innervating the iris or ciliary body, and the NPY-positive ganglion cells of the superior cervical ganglia innervating the iris, ciliary body, and choroid membrane served as the route for the virus spread. These findings also suggested that dopaminergic neurons, such as the TH-positive retinal cells and TH-positive ganglion cells of the superior cervical ganglia, served as the route for virus spread. 相似文献
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High dose hypofractionated frameless volumetric modulated arc radiotherapy is a feasible method for treating canine trigeminal nerve sheath tumors
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ROGER PETTIGREW HELENA RYLANDER TOBIAS SCHWARZ 《Veterinary radiology & ultrasound》2009,50(3):276-278
Brain magnetic resonance images from 42 dogs imaged between 2002 and 2007 were reviewed retrospectively to establish the incidence of trigeminal nerve contrast enhancement. These dogs had otherwise normal MR images and no clinical evidence of trigeminal nerve disease. Contrast enhancement of the entire trigeminal nerve was seen in 39 dogs and in the region of the trigeminal ganglion in all 42 dogs. When contrast enhancement of the trigeminal nerve was observed, the intensity was subjectively less than or equal to that of the pituitary gland. Contrast enhancement of the trigeminal nerve was seen in 42 dogs with no clinical evidence of trigeminal nerve pathology. 相似文献
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PROBABLE TRIGEMINAL NERVE SCHWANNOMA IN A DOG 总被引:1,自引:0,他引:1
J.H. Saunders DVM L. Poncelet DVM DScV C. Clercx DVM PHD F.R. Snaps DVM DScV P. Flandroy MD P. Capasso MD R.F. Dondelinger MD 《Veterinary radiology & ultrasound》1998,39(6):539-542
A 7-year-old male Husky dog developed atrophy of the right masseter muscle and pruritis of the right side of the face. A myogenic origin was excluded using muscular biopsy. Electrophysiologically, there was involvement of the motor and sensory fibers of the trigeminal nerve, suggesting a lesion located between the brainstem and the trigeminal ganglion. On MRI examination, a nodular mass was detected in the right caudal fossa. This mass was characterized by intense enhancement after injection of contrast medium. Because of the progressive clinical signs, electrophysiology, and MRI results, a presumptive diagnosis of a trigeminal nerve schwannoma was made. The animal's condition improved slightly with corticosteroids. The dog underwent euthanasia 3 months after initial presentation. Necropsy was not performed. 相似文献
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Reasons for performing study: Anaesthesia of the maxillary nerve of the horse has been described using several approaches, but sparse data exist to evaluate the accuracy of these methods. Objectives: This study compared 2 previously described approaches to the maxillary nerve to assess their relative accuracies. Methods: Thirty severed heads from horse cadavers were arranged to approximate the position of a live horse. Methylene blue (0.25 or 0.1 ml) was injected using a 19 gauge 90 mm spinal needle by one of 2 approaches, the method used being randomly allocated in each instance. Method ANG: angulated needle insertion on the ventral border of the zygomatic process of the temporal bone and directed rostromedially. Method PER: needle inserted perpendicular to the skin surface, ventral to the zygomatic process of the malar bone, level with the temporal canthus of the eye. Accuracy of dye deposition was assessed following dissection. Placement was categorised as ‘full hit’ (complete nerve coverage or dye deposition centred on nerve), ‘partial hit’ (partial nerve discolouration but dye not centred on nerve) or ‘miss’ (no nerve discolouration). Deposition of dye relative to the nerve and whether injection was performed on the left or right side of the head was recorded. A Chi‐squared test was performed to examine the relationship between the 2 methods. Results: Method ANG was performed 31 times, Method PER 28 times. Full hits were 10/31 (32%) vs. 9/28 (32%), partial hits 15/31 (49%) vs. 14/28 (50%) and misses 6/31 (19%) vs. 5/28 (18%) (Methods ANG vs. PER, respectively). Results were not statistically significantly different between the methods. Dye was deposited in the deep facial vein once by each method. Bone was contacted consistently with Method PER and 8/31 times with Method ANG. Conclusion and clinical relevance: Both methods appeared equivalent in terms of accuracy. Aspiration should always precede injection. 相似文献
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Seon Ah Park Soo Joung Park Seong Kyu Han 《Journal of veterinary science (Suw?n-si, Korea)》2010,11(4):299-304
The KA1 kainate receptor (KAR) subunit in the substantia gelatinosa (SG) of the trigeminal subnucleus caudalis (Vc) has been implicated in the processing of nociceptive information from the orofacial region. This study compared the expression of the KA1 KAR subunit in the SG of the Vc in juvenile, prepubescent and adult mice. RT-PCR, Western blot and immunohistochemistry analyses were used to examine the expression level in SG area. The expression levels of the KA1 KAR subunit mRNA and protein were higher in juvenile mice than in prepubescent or adult mice. Quantitative data revealed that the KA1 KAR subunit mRNA and protein were expressed at levels approximately two and three times higher, respectively, in juvenile mice than in adult mice. A similar expression pattern of the KA1 KAR subunit was observed in an immunohistochemical study that showed higher expression in the juvenile (59%) than those of adult (35%) mice. These results show that the KA1 KAR subunits are expressed in the SG of the Vc in mice and that the expression level of the KA1 KAR subunit decreases gradually with postnatal development. These findings suggest that age-dependent KA1 KAR subunit expression can be a potential mechanism of age-dependent pain perception. 相似文献