Results from the treatment of advanced stage squamous cell carcinoma of the nasal planum in cats, using a combination of intralesional carboplatin and superficial radiotherapy: a pilot study

Six cats with an advanced stage squamous cell carcinoma (SCC) of the nasal planum were treated with a combination of superficial radiotherapy and intralesional carboplatin therapy. This multimodality protocol was well tolerated by the majority of cats and resulted in complete responses in all cats (100%). Median follow‐up for all cats is 268 days, and the median time‐to‐recurrence, time‐to‐progression and overall survival have not yet been reached. Our study, although limited in number of animals and with a relatively short median follow‐up compared to other studies for this disease, suggests that a combination of radiotherapy and intralesional carboplatin is a useful treatment option for an advanced stage SCC of the nasal planum in cats and warrants further application of the multimodality approach presented here.     

Effects of perioperative saphenous and sciatic nerve blocks,lumbosacral epidural or morphine–lidocaine–ketamine infusion on postoperative pain and sedation in dogs undergoing tibial plateau leveling osteotomy

ObjectiveTo compare the quality of postoperative analgesia and sedation after preoperative saphenous and sciatic nerve blockade, preoperative lumbosacral epidural injection and perioperative intravenous (IV) morphine, lidocaine and ketamine infusions in dogs undergoing stifle arthroscopy and tibial plateau leveling osteotomy (TPLO) under general anesthesia.Study designProspective, blinded, randomized, clinical comparison study.AnimalsA total of 45 dogs weighing 33.9 (15.9–56.7) kg and aged 5.2 (1.0–12.0) years, mean (range), undergoing elective unilateral TPLO for spontaneous cranial cruciate ligament rupture.MethodsClient-owned dogs were enrolled. Dogs were randomly assigned to one of three groups: group MLK, perioperative IV morphine, lidocaine and ketamine infusion; group EPID, lumbosacral epidural with ropivacaine and morphine; or group SSNB, saphenous and sciatic nerve blockade with ropivacaine. Routine stifle arthroscopy followed by TPLO surgery was performed. Sedation and pain scores were assessed at 0, 2, 4, 8 and 24 hours following extubation. Rescue analgesia was administered as prescribed by Glasgow composite pain score–short form score >5.ResultsSedation scores for MLK were higher than EPID and SSNB. Pain scores for SSNB were lower than those for EPID and MLK. No significant differences were found in anesthesia duration or surgery duration among groups. No dogs required rescue analgesia.Conclusions and clinical relevanceAlthough analgesia was adequate in all groups, the best combination of analgesia without increased sedation was recorded for SSNB.     

The effects of maxillary nerve block,ethmoidal nerve block and their combination on cardiopulmonary responses to nasal stimulation in anesthetized Beagle dogs

ObjectiveTo describe an approach for ethmoidal nerve block (E_BLOCK) and to compare the effects of a maxillary nerve block (M_BLOCK), E_BLOCK and their combination (M-E_BLOCK) on heart rate (HR), systolic (SAP), mean (MAP), diastolic (DAP) arterial pressures and respiratory rate (f_R) during nasal stimulation in dogs.Study designProspective, blinded, randomized, crossover placebo-controlled study.AnimalsBeagle dogs (five cadavers, nine live dogs), with a median (interquartile range) weight of 10.5 (10.3–11.0) kg.MethodsThe accuracy of iohexol injections (each 1 mL) at the maxillary and ethmoidal foramina in cadavers was evaluated using computed tomography. Then, anesthetized dogs were administered four bilateral treatments separated by 1 week, saline or 2% lidocaine 1 mL per injection: injections of saline at the maxillary and ethmoidal foramina (Control), injections of lidocaine at the maxillary foramina and saline at the ethmoidal foramina (M_BLOCK), injections of saline at the maxillary foramina and lidocaine at the ethmoidal foramina (E_BLOCK) and injections of lidocaine at all foramina (M-E_BLOCK). The ventral nasal meatus was bilaterally stimulated using cotton swabs, and HR, SAP, MAP, DAP and f_R were continuously recorded. Values for each variable were compared before and after stimulation using Wilcoxon signed-rank test. Changes in variables among treatments were analyzed using Mann–Whitney U and Kruskal–Wallis tests (p ≤ 0.05).ResultsComputed tomography revealed iohexol distribution around the openings of the target foramina in all cadavers. In living dogs, HR, SAP, MAP, DAP and f_R significantly increased after stimulation within each treatment (p < 0.03). Physiologic responses were significantly attenuated, but not absent, in the M-E_BLOCK [HR (p = 0.019), SAP, MAP, DAP and f_R (all p ≤ 0.001)] compared with those in the Control.Conclusions and clinical relevanceConcurrent injections of lidocaine at the maxillary and ethmoidal foramina attenuated HR, arterial pressure and f_R responses to nasal stimulation in Beagle dogs.     

Visualization of the FEM Analysis Data of 3D on the Cut Plane

The colored patterns on arbitrary cut plane is an important method in 3D data-field visualization of finite element.By using the technology of the Object-Oriented Programming and the method of scan-line,the colored patterns on arbitrary cut plane are given.The example by the OPENGL of Visual C++ R6 can support the theory satisfactorily.     

A STATIC STRESS ANALYSIS OF THE EFFECT OF STRATIFICATION PLANE OF ROCK MASSES ON SMOOTH BLASTING

The influenfial factors of stratification plane to smooth blasting are studied according to the ti eory of smooth blasting and the anslysis of static stress. The results show that the angle p between the maximum principal plane and the rertical line of stratification plane has some influence on the fracture of rock masses.     

柴油机机体有限元结构分析

以柴油机机体为研究对象,利用ANSYS软件构建了精确的机体有限元接触模型,根据试算和经验确定了位移和载荷边界条件,对机体在各缸最大爆发压力下进行了结构强度和刚度分析,得到了机体在最大爆发压力下的最大变形点和最大应力点,分析了机体、气缸套、挺柱孔、轴瓦各处的变形和应力分布,考查了机体顶面和底面的密封性,并对原机体结构提出了改进建议。     

闸门的优化设计

用平面体系的方法进行结构分析，对排灌机械中平面钢闸门的面板－梁格体系的优化设计进行了探讨，用边界搜索法将有约束优化问题转换为无约束优化问题，给出了优化设计程序框图进行实例理论验证，结果表明，彩本文介绍的优化方法设计，闸门的叶体积可减小２０％左右。     

S385型柴油机机体三维有限元分析

针对S385型柴油机机体的结构特点,采用有限元分析方法对其进行了爆发工况的有限元静力分析。通过分析,得出了机体结构的位移、应力、应变云图,找到了机体结构强度的薄弱环节并据此提出了相应的修改方案,为改善机体强度、改进机体结构设计提供了理论依据。     

城市住宅小区绿化设计初探

为了增进人与自然和谐以及社会、经济、生态的可持续发展,阐述了园林植物在城市住宅小区绿化中的重要作用,对当前中国城市住宅小区绿化设计现状及存在问题进行了综合分析,提出了城市住宅小区绿化设计与自然生态环境的关系,以及通过植物配置的最佳方式来提高城市住宅小区园林绿化的综合效益。