Progress in autoantibodies to platelet and idiopathic thrombocytopenic purpura

The onset of idiopathic thrombocytopenic purpura (ITP) is related to excessive destruction of platelet resulting from antiplatelet autoantibody. The immunity with ITP is imbalance, so the hypofunction of suppressor T cell (Ts) can't restrain B lymphocytes producing antibody, as a result, autoant ibody is produced, the clearance of platelet in blood circulation is accelerated. The different antibodies have different functions on ITP. The measuring of platelet antibody has its significance in diagnosis, therapeutic evaluat ion and expectation of prognosis.     

引发奶牛乏情的疾病研究进展

奶牛乏情是指产后60～90 d没有发情表现的经产奶牛及14～18个月龄不发情的育成牛,机体不表现出任何明显的发情状态,导致卵泡发育不良,从而影响机体排卵,引起发情周期紊乱、妊娠推迟,这对奶牛业的发展产生重大的影响。本文主要综述奶牛出现乏情状态的繁殖性疾病的研究状况,为进一步研究奶牛产后乏情提供理论依据。     

Expression of PDGFR-β and Kit in canine anal sac apocrine gland adenocarcinoma using tissue immunohistochemistry

Canine anal sac apocrine gland adenocarcinoma (ASAGAC) is an uncommon but highly invasive and metastatic malignancy. Toceranib phosphate (Palladia) is a receptor tyrosine kinase (RTK) inhibitor that targets several members of the split kinase RTK family. These membrane receptors are important for cell cycling, apoptosis and angiogenesis, all of which can contribute to carcinogenesis. The objective of this study was to evaluate archived, paraffin-embedded canine ASAGAC and normal canine anal sacs for immunohistochemical detection of Kit and platelet-derived growth factor receptor beta (PDGFR-β). Two of 77 neoplasms (2.6%) expressed Kit. Fifteen of the neoplasms (19.5%) were positive for PDGFR-β expression. None of the normal canine anal sac epithelium expressed Kit or PDGFR-β. Because of these results, further investigation should be considered to determine the role of RTKs in the clinical course and treatment of canine ASAGAC.     

冠心病血瘀证与血液检验相关指标分析

目的 探讨冠心病血瘀证与血液相关检验指标的关系。方法 选择175例冠心病患者,其中血瘀证组112例,非血瘀证组63例。研究对象均在住院次日清晨平躺测量血压,空腹状态下抽取静脉血液留置标本,检测血常规和血脂、血糖、肾功能等生化指标,记录患者吸烟史。比较两组患者指标的差异性。结果 血瘀证组患者的血常规中红细胞分布宽度-CV值（Rdw-cv）、红细胞分布宽度-SD值（Rdw-sd）、血小板分布宽度（Pdw）、血小板平均体积（Mpv）、血小板比积（Pct）、大型血小板比率（P-lct）均明显高于非血瘀证组（P<0.01,P<0.05）;血瘀证组患者载脂蛋白B（ApoB）、血脂总胆固醇（TC）均明显高于非血瘀证组（P<0.01,P<0.05）;血瘀证组中患者吸烟率明显高于非血瘀证组（P<0.05）。结论 冠心病血瘀证组患者Rdw-cv、Rdw-sd、Pdw、Mpv、Pct、P-lct、TC、ApoB及烟率均明显高于非血瘀证组,差异具有统计学意义,故以上指标可以作为冠心病血瘀证中医辨证分型的客观临床指标。