不同剂量伊曲康唑制剂对犬血常规及肝肾功能的影响

旨在评价不同剂量伊曲康唑-环糊精制剂通过皮下注射途径对健康比格犬肝肾功能及血常规的影响.选用体重±10 kg的健康纯种比格犬32只,按试验要求随机分为4组,每组8只,建立稳定的生活制度.分别按照0.25 mg/kg、0.75 mg/kg和1.25 mg/kg剂量,皮下注射伊曲康唑制剂,3日1次,连续7次,对照组注射生理...     

HPLC法测定犬血浆中伊曲康唑浓度

应用高效液相色谱法（HPLC）测定犬血浆中伊曲康唑的浓度。选用6条健康犬,以4mg／kg体重背部皮下注射给药,采用HPLC测定犬血浆中伊曲康唑浓度（ITZ）,应用3p97软件处理数据,计算药代动力学参数。结果表明血浆ITZ线性范围为10～1000ng／mL,伊曲康唑血浆添加浓度10、100、500ng／mL的平均回收率分别为86．9％、88．4％、89．2％,RSD分别为2．8％,1．2％,0．2％。说明HPLC法简便,准确可靠,适用于伊曲康唑在犬体药动学中血药浓度测定。     

A Case of Equine Aspergillosis: A Novel Sampling Procedure for Diagnosis

Aspergillus spp. may induce equine respiratory infections such as fungal pneumonia, guttural pouch mycosis, and systemic infection in immunocompromised individuals. This study describes a case of probable respiratory aspergillosis in a horse presenting clinical signs of the upper airway disease different from those previously reported. Nasopharyngeal swabs and guttural pouch centesis were performed, and Aspergillus flavus was isolated and identified. Following 30 days of pharmaceutical treatment with itraconazole, clinical signs resolved. Results suggested that aspergillosis should be included in the differential diagnosis of upper airway infections, guttural pouch centesis may be useful to make a correct diagnosis, and itraconazole is efficacious in the treatment of A flavus infection.