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1.
Speckle‐Tracking Echocardiography in Dogs With Patent Ductus Arteriosus: Effect of Percutaneous Closure on Cardiac Mechanics 下载免费PDF全文
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Echocardiographic Assessment of Cardiac Function by Conventional and Speckle‐Tracking Echocardiography in Dogs with Patent Ductus Arteriosus 下载免费PDF全文
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Zandvliet MM Rothuizen J 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2007,21(2):215-218
BACKGROUND: Irish Wolfhounds frequently have a congenital portosystemic shunt, but a considerable proportion of the 6- to 8-wk-old pups has hyperammonemia in the absence of portosystemic shunting. This hyperammonemia causes no signs and is transient, normalizing at the age of 3-4 months. HYPOTHESIS: Transient hyperammonemia has a metabolic basis in Irish Wolfhounds. ANIMALS: Two related (same sire) litters of Irish Wolfhounds (17 pups) and their parents were studied. METHODS: Integrity of the portal circulation was examined by ultrasonography and scintigraphy. Absence of parenchymal liver disease was verified by liver biopsy. Amino acid profiles were measured in 4 pups and repeated in 2 of these pups when ammonia concentrations had normalized. The amino acid profiles were compared with those of healthy Irish Wolfhound pups. RESULTS: Fasting venous ammonia concentrations were high (113-622 microg/dL, 65-345 micromol/L) in all pups, whereas bile acids were within reference range in all but 1. The ammonia and bile acid concentrations from all parents were within reference range. Portosystemic shunting was excluded in all but 1 pup. Liver biopsy excluded significant lesions in all 10 pups examined. Hypercitrullinemia was found and persisted even when ammonia had normalized, at the expense of an increase in glutamine and asparagine. CONCLUSIONS AND CLINICAL IMPORTANCE: Citrulline concentrations are controlled by the urea cycle enzymes argininosuccinase and argininosuccinate synthetase, and a defect in either of these enzymes may be responsible for the transient hyperammonemia in Irish Wolfhounds. Resolution of the hyperammonemia is associated with increased activity of alternative metabolic pathways forming glutamine and asparagine. Confirmation requires measurement of enzyme activities in liver tissue. 相似文献
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A 5-year-old Oldenburg mare presented for poor performance, head-tossing and bucking when ridden. An abnormal respiratory noise was audible during exercise. Computed tomography (CT) revealed right laryngeal dysplasia; an absent cricothyroid articulation, abnormally shaped thyroid cartilage, underdeveloped cricopharyngeus muscle, rostral displacement of the palatopharyngeal arch and an oesophageal air column. In this case, it was unlikely that the laryngeal pathology was related to the horse's clinical signs. This case report provides a reference CT examination of laryngeal dysplasia, corroborating previous findings using magnetic resonance imaging, radiography, ultrasonography and post-mortem examination. 相似文献
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The damage of bridge cable directly hazards the normal use of bridge and the safety of people. The paper discussed the signal acquisition and detection system which takes embedded DSP processor as core technology, combined with CCD, video decode chip, SDRAM, FLASH ROM, and established the fast measuring algorithm of the surface corrosion and damage, which includes deteminating the processing region, improving medium filter, sobel edge detection and dynamic threshold segment, close operation of morphology, computing defect area and saving. The experimental resuits show that this method implemented the real-time, non-contact and intelligence detecting of cable surface defect and gives the specifications of the system. 相似文献
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AIM:To investigate the effects of histone methylation on the abnormal expression of cardiomyogenesis genes caused by alcohol during pregnancy and the regulatory mechanism, and to provide a new idea and intervention targets for preventing and curing congenital heart disease. METHODS:The alcohol (56%, 5 mL/kg) and G9a-histone methyltransferases (HMT) inhibitor BRD4770 (1 mg/kg) were given by gavage in Kunming mice during embryo (E) 0.5~14.5 d, and the hearts of the mice in E14.5, E16.5 and post neonatal 0.5 d (PND0.5) were collected. The mRNA expression of Gata4, Cx43 and β-MHC genes was detected by RT-qPCR. The activity of HMT was measured by colorimetry. Meanwhile, the protein expression of histone H3K9me3, G9a-HMT, Cx43 and β-MHC was determined by Western blot. RESULTS:The results of colorimetry showed that the activity of HMT in the heart of the offspring mice treated with alcohol during pregnancy was decreased significantly compared with normal saline group (P<0.05), and Western blot data showed that the expression of G9a-HMT and histone H3K9me3 were apparently decreased in the same samples (P<0.05). The mRNA expression levels of Gata4, Cx43 and β-MHC in alcohol group were apparently increased compared with normal saline group (P<0.05). Meanwhile, the protein levels of Cx43 and β-MHC were increased significantly in the same samples (P<0.05). However, BRD4770, a G9a-HMT inhibitor, further attenuated the level of histone H3K9me3, and further upregulated the expression of Gata4, Cx43 and β-MHC in the heart of the the mice treated with alcohol (P<0.05). CONCLUSION:Histone methylation modification imbalance induced by G9a-HMT may be involved in the abnormal expression of cardiomyogenesis genes in the heart of offspring mice caused by alcohol during pregnancy. 相似文献
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研究提出了一种基于机器视觉的病害和裂纹的识别方法。在H分量图中,依据半干枣在病害和非病害区域色调值差异提取病害区域,以提取的病害区域与枣表面积的比作为阈值确定较高的病害面积识别精度,可正确识别的感兴趣病害面积为16.87mm2,占枣投影面积的3.3%。为进一步提高在该病害面积识别精度的正确率,依据已确定的病害面积比阈值,将病害面积比值二值化,结合红枣区域颜色特征值H的均值和均方差,用SVM方法建立枣病害的识别模型,训练集和测试集的识别正确率分别为9 5.7 7%和9 5.7 9%。在I分量图中,对红枣区域进行Otsu’s阈值分割、图像局部属性统计和形态学处理,提取裂纹二值图像,依据裂纹图像不变距方法建立裂纹识别模型,训练集和测试集的识别正确率分别为94.90%和94.55%。 相似文献
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