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The essential oil obtained by hydrodistillation of the resin of Canarium schweinfurthii growing in Central African Republic, was analysed by GC and GC/MS and its analgesic and antiinflammatory effects were studied. The major constituents of the essential oil were octylacetate (60%) and nerolidol (14%). At the doses of 1, 2 and 3 ml/kg i.p. essential oil shows a significant analgesic effect using acetic acid-induced writhing and hot plate methods. However, its was unable to reduce inflammatory process in cotton pellet induced granuloma method. 相似文献
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[目的]为复方牛山参口服液的临床应用提供参考。[方法]以昆明种小白鼠为试验动物,10ml/kg生理盐水处理为空白对照,研究25ml/kg消炎痛及2.5、5.0、10、20g/kg复方牛山参口服液灌胃处理对小白鼠扭体反应和耳廓肿胀的影响,考察复方牛山参口服液镇痛抗炎作用的量效、时效关系。[结果]25ml/kg消炎痛及2.5、5.0、10、20g/kg复方牛山参口服液对小白鼠扭体次数的抑制率分别为81.73%、33.65%、38.46%、50.48%、76.73%,对小白鼠耳廓肿胀的抑制率分别为15.14%、6.23%、5.20%、18.20%、27.22%;5.0g/kg复方牛山参口服液灌胃处理0、1、2、3、6.5h后,扭体鼠发生率分别为50%、50%、10%、10%、0。[结论]复方牛山参口服液的镇痛作用较消炎痛稍差,但其对小白鼠耳廓肿胀的抑制作用优于消炎痛。 相似文献
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中药清温消热饮的抗炎镇痛活性研究 总被引:1,自引:1,他引:0
为了研究清温消热饮的抗炎、镇痛作用,选择清洁级昆明系小鼠144只作为试验对象,采用小鼠炎性肿胀、疼痛反应模型对其进行药效学综合分析,结果显示,清温消热饮对小鼠的耳廓肿胀和足趾肿胀的4 h抑制率分别为23%和59.34%,与西药对照组地塞米松治疗效果无差异性(P0.05),与空白对照组比较差异极显著(P0.01)。同时,清温消热饮组能延长小鼠疼痛反应时间和有效减少小鼠扭体反应次数,表现出与空白对照组显著差异(P0.01)。结果表明清温消热饮抗炎效果显著,并具有良好的镇痛作用,试验为该中药方剂的进一步研发提供了支持。 相似文献
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During fattening, the bodyweight of modern broad-breasted turkeys increases considerably within a very short space of time. In particular, the breast muscles increase disproportionately. This leads to a disadvantageous distribution in weight, and as a consequence, to a disturbed leg position and skeletal deformations like antitrochanteric degeneration, tibial dyschondroplasia, bending, twisting and rotation of the tibia, osteochondrosis, osteomyelitis, rickets, and epiphyseolysis of the femoral head increases. This cases of degenerative joint disease cause severe pain in humans and there are indications that this is also true for turkeys. The purpose of this study was to determine if behaviour indicative of such pain in turkeys of the B.U.T. Big 6 breeding line could be attenuated by administering a quick-acting analgesic, butorphanol. Twelve pairs of turkeys were tested at the ages of 7 and 12 weeks. One bird in each pair received an analgesic opioid injection, while the other one received a control injection of physiologically balanced saline solution. The time the birds spent putting weight on their legs, i.e., 'walking' and 'standing' and the distance covered by the birds were recorded during the 30 min periods before and after the application of the drug. At week seven the treated birds spent significantly more time putting weight on their legs than control birds. At week 12, the same tendency was observed. No significant differences were found in the distances covered by the animals. It is concluded that fattening turkeys reduce the time they are putting weight on their legs because these behaviours may be associated with pain. 相似文献
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Oral administration of the ethanolic extract (200 and 400 mg/kg, p.o) and its fractions (200 mg/kg each) of the aerial parts of Cleome rutidosperma produced significant analgesic activity in acetic acid-induced writhing and tail immersion tests, anti-inflammatory effect against carrageenin induced inflammation and adjuvant induced polyarthritis and antipyretic activity against yeast-induced pyrexia. Fractionation of the ethanolic extract potentiated the activities. 相似文献
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Transdermal absorption of four lidocaine (L) patches (5%) was compared with the transdermal absorption of L cream (5%) to evaluate the pharmacokinetics of the two formulations applied on the same anatomic region under dressing in eight horses. The animals were also assessed for antinociceptive effect after removal of the patches and cream, using a psychophysical method visual analog scale, by pricking the patient's skin to test the response to pain. Horses were randomly assigned to four treatment groups: in groups I and II, four L patches were applied for a period of 24 hours with and without alcohol precleaning, respectively; in group III, 5% L cream was applied every 2 hours over a 24-hour period on the same anatomic site. Group IV was the control. No clinical side effects were noted with either formulation. L was detectable in plasma 6 to 24 hours after application of the patches, and the highest plasma concentrations were reached between 12 and 18 hours. The use of alcohol to preclean the skin appeared to reduce the transdermal drug absorption over time. After L cream application, the peak plasma drug concentration occurred at 24 hours. Nociception assessment after L patch or L cream application showed a decreased response when the L cream was used. The results of this study showed that there was minimal absorption from the L patches compared with the L cream in horses. Also, the L cream treatment reduced significantly the intensity of nociception quality as measured by the visual analog scale. 相似文献
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Two new neolignans (1 and 2) were isolated from the root bark of Illicium henryi, along with four known neolignans and seven known flavonoids (3–13). Their structures were elucidated on the basis of spectroscopic and chemical methods. The absolute configurations of compounds 1 and 2 were determined by the CD spectrum. 相似文献