周恩来图书资料意识与文物保护意识及其实践

周恩来图书资料意识和文物保护意识充分体现其强烈的民族责任感和一位伟大革命者的历史文化胸怀。周恩来是我国图书馆和博物馆建设事业的主要倡导者和领导者,其高度关注新中国图书馆和博物馆建设事业,并明确阐明新中国图书馆和博物馆建设事业的基本思想,为我们建设有中国特色社会主义图书馆和博物馆指明了方向。     

北京松山植物的研究

松山有维管束植物109科413属783种及变种,有4个新变型。植物区系属于泛北极植物区,中国-日本亚区。以温带分布类型为主。植物群落有9个类型。已知有用资源植物有11类,以药用植物种类最多,有326种,其次是油脂植物、纤维植物、鞣料植物等,用材树木只有53种,但真正能作用材的树种不过20种。对42种重要资源植物的蕴藏量进行了估测。     

COPPER EFFECTS ON PRUNUS PERSICA IN TWO DIFFERENT GRAFTING COMBINATIONS (P. PERSICA × P. AMYGDALUS AND P. CERASIFERA)

Growth, chlorophyll content, biomass dry weight (DW), nutrient uptake and copper (Cu) accumulation were evaluated in BigTop® peach (Prunus persica L. Batsch) grafted onto two different rootstocks [GF677 (P. persica × P. amygdalus) and Mr.S2/5 (P. cerasifera)] when grown in the presence of 0.1, 10 or 100 μM copper sulfate (CuSO₄). Although scion shoot length varied significantly in response to Cu concentration only with Mr.S2/5 rootstock (40%reduction at 100 μM Cu compared with control), Cu concentration in the scion grafted on GF677 was higher (18.2 mg kg^?1) compared to that grafted on Mr.S2/5 (10.5 mg kg^?1). In both graft combinations, the Cu concentrations in leaves were not statistically different although values ranged between 4.7 and 8.1 mg kg^?1. The DW of leaves and stems was not statistically different from control plants in both graft combinations. On the contrary, root DW of Mr.S2/5 increased, about 13% at 10 μM Cu and 43% at 100 μM Cu. In contrast, DW of GF677 roots at higher Cu treatment was significant lower than control. Chlorophyll reduction Cu induced was not found, suggesting that the degradation of these pigments is maintained at low levels. The uptake of sodium (Na), zinc (Zn), and iron (Fe) changed during Cu stress. The different behavior observed between GF677 and Mr.S2/5 regarding Cu accumulation proves that these two rootstocks have a different ability in translocation and accumulation of Cu in presence of this heavy metal. The use of GF677 rootstocks, in substrates particularly rich of Cu, insures a better development of scion growth when compared to Mr.S2/5, but determines a higher Cu concentration in the stem, while Mr.S2/5 seems to be able to stabilize the Cu concentrations in the scion.     

Structural and Functional Characterization of a Novel α-Conotoxin Mr1.7 from Conus marmoreus Targeting Neuronal nAChR α3β2, α9α10 and α6/α3β2β3 Subtypes

In the present study, we synthesized and, structurally and functionally characterized a novel α4/7-conotoxin Mr1.7 (PECCTHPACHVSHPELC-NH₂), which was previously identified by cDNA libraries from Conus marmoreus in our lab. The NMR solution structure showed that Mr1.7 contained a 3₁₀-helix from residues Pro⁷ to His¹⁰ and a type I β-turn from residues Pro¹⁴ to Cys¹⁷. Electrophysiological results showed that Mr1.7 selectively inhibited the α3β2, α9α10 and α6/α3β2β3 neuronal nicotinic acetylcholine receptors (nAChRs) with an IC₅₀ of 53.1 nM, 185.7 nM and 284.2 nM, respectively, but showed no inhibitory activity on other nAChR subtypes. Further structure-activity studies of Mr1.7 demonstrated that the PE residues at the N-terminal sequence of Mr1.7 were important for modulating its selectivity, and the replacement of Glu² by Ala resulted in a significant increase in potency and selectivity to the α3β2 nAChR. Furthermore, the substitution of Ser¹² with Asn in the loop2 significantly increased the binding of Mr1.7 to α3β2, α3β4, α2β4 and α7 nAChR subtypes. Taken together, this work expanded our knowledge of selectivity and provided a new way to improve the potency and selectivity of inhibitors for nAChR subtypes.     

涵芬楼和东方图书馆小史

记录涵芬楼和东方图书馆的兴衰史.     

《马氏文通》的承接连字及相关问题

通过对《马氏文通》“承接连字”有关论述的研读，以讨论的方式分析了“承接连字”的有关问题，探讨了《马氏文通》在研究汉语词类连接功能、词类区分标志、复合虚词研究、汉语语法化研究等问题时给我们的启示，并试图提出语法研究的新课题。