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1.
Hamster sperm hyperactivation is enhanced by progesterone, and this progesterone-enhanced hyperactivation is suppressed by 17β-estradiol (17βE2) and γ-aminobutyric acid (GABA). Although it has been indicated that melatonin also enhances hyperactivation, it is unknown whether melatonin-enhanced hyperactivation is also suppressed by 17βE2 and GABA. In the present study, melatonin-enhanced hyperactivation was significantly suppressed by 17βE2 but not by GABA. Moreover, suppression of melatonin-enhanced hyperactivation by 17βE2 occurred through non-genomic regulation via the estrogen receptor (ER). These results suggest that enhancement of hyperactivation is regulated by melatonin and 17βE2 through non-genomic regulation. 相似文献
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探讨3种性类固醇激素在北方山溪鲵精子发育过程中的调控作用.用免疫细胞化学方法对3种激素在山溪鲵精子发生周期不同时期在精巢中的细胞定位进行检测.结果表明雄激素分布在精原细胞的胞质中,尔后转移到精母细胞及精子细胞的核中;雌激素一直存在于生精细胞的胞质及核膜周围;孕激素分布在精原细胞及精母细胞的胞质中,随后在精子细胞的核质中有表达.雄激素在早期的精子发生和转型中起作用,而雌激素主要以非基因组效应参与生精细胞的增殖,孕激素在精子发育后期精子细胞的变态中起作用.3种激素以不同的方式调控精子的发生. 相似文献
3.
(-) Hydroxycitric acid (HCA), an active ingredient extracted from the Garcinia cambogia fruit rind, has been commonly used as a dietary supplement for weight management. Given the controversy over HCA related testicular toxicity in animal studies, we investigated changes in serum sex hormones levels as an extension of our previous double-blind placebo-controlled trial in human subjects, in which 44 participants received either G. cambogia extract (1667.3 mg/day equivalent to 1000 mg HCA/day) or placebo for 12 weeks. Compared to the placebo group, administration of the extract did not significantly alter the serum testosterone, estrone, and estradiol levels. Similarly, hematology, serum triacylglycerol and serum clinical pathology parameters did not reveal any significant adverse effects. The results of this preliminary investigation indicate that ingestion of G. cambogia extract at dose levels commonly recommended for human use does not affect serum sex hormone levels and blood parameters. 相似文献
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[目的]探讨广西地区笼养雌性食蟹猴配种后生殖激素的变化水平。[方法]采用放射免疫分析法(RIA)测定食蟹猴配种后血清雌二醇(E1)、孕酮(P)和催乳素(PRL)的水平变化。[结果]结果表明,在配种后1~60d孕酮的含量缓慢降低,第60天降到最低水平(0.22±0.06)ng/ml,其后缓慢上升。第105天出现一个大的峰值,为(1.15±0.12)ng/ml,峰值过后浓度呈下降趋势,整个测定时期的平均值为(0.66±0.08)ng/ml。雌二醇的含量除了在第75天有一个较大的峰值[(86.92±18.54)pg/ml]外一直处于一个稳定的水平,在第120天后呈逐渐上升的趋势,整个测定时期的平均值为(35.16±5.12)pg/ml。催乳素的含量在配种后1~90d稳步上升,第90天出现一个小的峰值,为(99.62±44.56)IU/ml。第105天后含量上升较快,催乳素在整个测定时期的平均值为(103.64±37.36)IU/ml。[结论]该研究为采用食蟹猴作为动物模型探讨不孕不育的病因和发病机理提供参考依据。 相似文献
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Yojiro YANAGAWA Yukiko MATSUURA Masatsugu SUZUKI Shin-ichi SAGA Hideto OKUYAMA Daisuke FUKUI Gen BANDO Masashi NAGANO Seiji KATAGIRI Yoshiyuki TAKAHASHI Toshio TSUBOTA 《The Journal of reproduction and development》2015,61(1):61-66
Generally, sika deer conceive a single fetus, but approximately 80% of pregnant females have two corpora lutea (CLs). The function of the accessory CL (ACL) is unknown; moreover, the process of ACL formation is unclear, and understanding this is necessary to know its role. To elucidate the process of ACL formation, the ovarian dynamics of six adult Hokkaido sika deer females were examined ultrasonographically together with peripheral estradiol-17β and progesterone concentrations. ACLs formed in three females that conceived at the first estrus of the breeding season, but not in those females that conceived at the second estrus. After copulation, postconception ovulation of the dominant follicle of the first wave is induced by an increase in estradiol-17β, which leads to formation of an ACL. A relatively low concentration of progesterone after the first estrus of the breeding season is considered to be responsible for the increase in estradiol-17β after copulation. 相似文献
9.
XU Jing-ting CAO Ya-lin ZHENG Wen-hui ZHANG Ya-xing WANG Ling WANG Ting-huai 《园艺学报》2015,31(6):1008-1013
AIM: To investigate the effect of Jia-jian-yi-yin decoction on endothelium-dysfunction in ovariectomized rats. METHODS: The ovariectomized rats were treated with Jia-jian-yi-yin decoction or turbid liquid of estradiol valerate for 8 weeks. The vascular ring tension was measured. Scanning electron microscopy and Western blotting were applied to assess the function of endothelium-dependent dilation, aortic endothelial morphology and the expression of endothelial lipase. The pathologic sections were prepared to observe the effect of Jia-jian-yi-yin decoction on the uterus. RESULTS: In ovariectomized rats, the decrease in endothelium-dependent relaxation to acetylcholine (ACh) was reversed to normal level, the endothelial morphology returned to normal without lipid accumulation and the endothelial lipase expression was decreased by Jia-jian-yi-yin decoction. Furthermore, no obvious change of the wet weight of uterine between the ovariectomized rats with or without Jia-jian-yi-yin decoction treatment was observed. CONCLUSION: Jia-jian-yi-yin decoction may have protective effects on endothelium-dependent vasodilation and aortic endothelial morphology in estrogen-deficient animals. 相似文献
10.
特定电磁波(TDP)辐射器,通过电热激发,可产生2-25μm红外光谱,其峰值为9μm,具有对生物体有益的特异生物效应,目前在中国已广泛地应用。奶牛产后乏情达3个月以上且无卵泡发育者,用特定电磁波(TDP)居髎穴区照射,照射组(30头)在照射的21天内16头发情,对照组(30头)在此期间仅1头发情,两者比较,差异极显著;经3个情期配种,照射组16头发情牛中15头妊娠(第一情期配种8头妊娠),对照组1头发情牛经3个情期配种没有妊娠,两者比较,差异极显著。用放射免疫方法测定经照射发情16头奶样中雌二醇(E#-2)和孕酮(P#-4)含量变化曲线与正常发情牛周期中两种性腺激素含量变化规律一致,对照组牛奶样中雌二醇(E#-2)和孕酮(P#-4)没有规律性变化。 相似文献