Relationship between the intracellular calcium concentration changes and left ventricular hypertrophy and function in the spontaneously hypertensive rats

AIM:To elucidate the relationship between the intracellular calcium concentration changes and left ventricular hypertrophy and function in the spontaneously hypertensive rats (SHR).METHODS:Intracellular free calcium concentrations were measured by Fura 2 methodology and left ventricular function quantitated by cardiac catheterization in 20 SHR aged 10, 22, and 34 weeks and 20 age-matched Wistar-kyoto (WKY) rats.RESULTS:(1) The systolic blood pressure(SBP), intracellular calcium concentrations and left ventricular mass / body weight index (LVM/BW) were significantly higher in all three age groups of SHR than the corresponding groups of WKY; (2) Compared with age-matched WKY groups, the peak left ventricular pressure descending rate(-dp／dt_max) decreased while left ventricular relaxation time constant (τ)increased significantly in SHR aged 22 and 34 weeks. The peak left ventricular pressure ascending rate(dp／dt_max) and the left ventricular contractility index were significantly increased only in the 34 weeks SHR; (3) Intracellular calcium concentrations showed a positive correlation with LVM/BW,SBP,-dp／dt_max and τ(r=0.47-0.83,P<0.01)and a negative correlation with dp／dt_max and the left ventricular contractility index (r=-0.46,P<0.05 and r=-0.81, P<0.01).CONCLUSION:Intracellular calcium overload is one of the potential mechanisms in the induction of left ventricular hypertrophy as well as of systolic and diastolic dysfunction.     

Effect of moxonidine hydrochloride on left ventricular hypertrophy in spontaneously hypertensive rats

AIM:To investate the effect of domestric moxonidine hydrochloride on myocardium fibrosis and coronary artery microvascular structure in left ventricular hypertrophy of spontaneously hypertensive rats(SHR).METHODS:30 male SHR, aged 20 weeks, were divided into group Mox+SHR, Cap+SHR and SHR randomly (10 in each group). 10 age and sex-mached sprauge-dawley rats were designed as normal control(NC). At the end of 13 weeks, left ventricular wight/body weight ratio(LVW/BW), collagen volume fraction(CVF) and standardized perivascular collagen area(PVCA) as well as intramyocardial arterial average medial thickness (AMT) were determined.RESULTS:LVW/BW, CVF, PVCA and AMT in group Mox+SHR were lower significantly than that in group SHR, respectively.CONCLUSION:Long-term antihypertensive treatment with moxonidine hydrochloride reduces myocardium fibrosis and improves impaired coronary artery microvascular structure in left ventricular hypertrophy.     

左右岸省界缓冲区水质达标评价方法研究

左右岸省界缓冲区作为协调省际间用水关系的重要水域,其水质达标评价及污染责任划分是流域限制纳污红线制度实施的重要内容。从左右岸省界缓冲区的相关概念出发,根据省份的位置关系将其分为缓冲区完全在两省省界上、缓冲区部分在两省省界上以及缓冲区在多省交界上三种情形,并结合左右岸省界缓冲区特点确定调整浓度核算法、代表断面判断法、限制排污总量-污染物入河量评估法等水质达标评价方法,以判断左右岸省份缓冲区的水质达标情况,从而划分缓冲区左右岸省份的污染责任。实例验证模拟显示,确定的方法切实可行,研究方法可为流域污染责任划分提供技术支撑,从而促进限制纳污制度的顺利实施。     

Evaluation of left ventricular function with cardiac magnetic resonance imaging and echocardiography after administration of dobutamine and esmolol in healthy beagle dogs

Unlike echocardiography, cardiac magnetic resonance imaging (cardiac MRI) results in a near-exact assessment of cardiac structures and function. However, most veterinary studies have focused on dogs with normal cardiac function. We hypothesized that there would be significant differences in cardiac measurements between cardiac MRI and echocardiography when left ventricular (LV) function was abnormal. This study was undertaken to compare measurements of LV function produced by cardiac MRI and echocardiography in dogs whose LV function was altered by pharmacological agents. This study was conducted with six healthy beagle dogs. We increased left ventricular contractility by administration of dobutamine; we decreased cardiac contractility with esmolol. Stroke volume measurements were made by using both cardiac MRI and echocardiography under seven different conditions with general anesthesia: control, three doses of esmolol (100, 200, and 500 µg/kg/min), and three doses of dobutamine (10, 20, and 50 µg/kg/min). Experiments involving each condition were conducted at least 1 week apart. When LV contractility was normal, ejection fraction (EF) and stroke volume (SV), as measured by echocardiography and cardiac MRI, were not significantly different. However, when contractility was changed by pharmacological agents, EF and SV were overestimated by echocardiography, compared to MRI. Evaluation of cardiac function in patients treated with pharmacological agents should be conducted carefully because EF and SV measured by echocardiography can be overestimated, compared with EF and SV obtained by cardiac MRI.     

The Stability of Quaternion Metrices and Their Judging Criteria

Some conceptions of stable quaternion matrices and some judging criteria are given.The Robrach theorem,Taussky theorem,Ostrowski Schneider theorem and Gerschgorin theorem are generalized to quaternion field.The conclusion about two quaternion matrices,i.e.,inferior positive matrices are unstable,interior negative matrices are stable and some other results are pointed out.     

降脂消斑片对冠心病患者左心室收缩功能的影响

目的 评价降脂消斑片对冠心病患者左心室收缩功能的影响。方法 将60例冠心病患者随机分为对照组30例和观察组30例。两组均服用复方丹参滴丸治疗,观察组加服降脂消斑片治疗,疗程为8周。对两组治疗前后均进行心脏长轴切面18节段斑点追踪成像（STI）的纵向峰值应变（LS）参数测定及心电图观察。结果 观察组在提高各节段STI的LS方面均优于对照组,差异有显著统计学意义（P<0.01）。两组患者心电图疗效比较,观察组疗效优于对照组,差异有统计学意义（P<0.05）。结论 降脂消斑片能改善冠心病患者左心室收缩功能。     

Diagnostic imaging and pacemaker implantation in a domestic goat with persistent left cranial vena cava

Difficulty was encountered with the insertion of a right atrial pacing lead via the left jugular vein during lead and pacemaker implantation in a clinically normal goat as part of an ongoing rapid atrial pacing – induced atrial fibrillation research project. Fluoroscopic visualization of an abnormal lead advancement path prompted angiographic assessment which revealed a persistent left cranial vena cava (PLCVC) and prominent coronary sinus communicating with the right atrium. Angiography facilitated successful advancement and securing of the pacing lead into the right side of the interatrial septum. Cardiac magnetic resonance imaging/magnetic resonance angiography (MRI/MRA) allowed further characterization of this rare venous anomaly. Even though PLCVC has been reported once in a goat, to the authors' knowledge this is the first report to include MRI/MRA characterization of PLCVC and prominent coronary sinus with successful cardiac pacemaker implantation using the PLCVC.     

支配猪左心室侧壁的交感神经节后神经元的定位

用HRP法研究了猪左心室外侧壁的交感神经节后神经元的分布,结果表明:标记细胞位于左侧颈中神经节、右侧椎神经节、双侧颈胸神经节及第二至第四胸交感神经节。标记细胞以颈胸节最多,占59.4％。左侧出现的标记细胞数明显多于右侧。标记细胞为多突起的星形运动神经元,以直径20～30μ为主,占67％。颈胸神经节内的标记细胞,大部分位于节的前腹侧部。颈前神经节内未发现标记细胞。     

刑法第一百条评析

通过对我国刑法第一百条的分析,认为它在本质上属刑罚的后遗效果。它的存在有其合理性,亦有弊端。