Relationship between the intracellular calcium concentration changes and left ventricular hypertrophy and function in the spontaneously hypertensive rats

AIM:To elucidate the relationship between the intracellular calcium concentration changes and left ventricular hypertrophy and function in the spontaneously hypertensive rats (SHR).METHODS:Intracellular free calcium concentrations were measured by Fura 2 methodology and left ventricular function quantitated by cardiac catheterization in 20 SHR aged 10, 22, and 34 weeks and 20 age-matched Wistar-kyoto (WKY) rats.RESULTS:(1) The systolic blood pressure(SBP), intracellular calcium concentrations and left ventricular mass / body weight index (LVM/BW) were significantly higher in all three age groups of SHR than the corresponding groups of WKY; (2) Compared with age-matched WKY groups, the peak left ventricular pressure descending rate(-dp／dt_max) decreased while left ventricular relaxation time constant (τ)increased significantly in SHR aged 22 and 34 weeks. The peak left ventricular pressure ascending rate(dp／dt_max) and the left ventricular contractility index were significantly increased only in the 34 weeks SHR; (3) Intracellular calcium concentrations showed a positive correlation with LVM/BW,SBP,-dp／dt_max and τ(r=0.47-0.83,P<0.01)and a negative correlation with dp／dt_max and the left ventricular contractility index (r=-0.46,P<0.05 and r=-0.81, P<0.01).CONCLUSION:Intracellular calcium overload is one of the potential mechanisms in the induction of left ventricular hypertrophy as well as of systolic and diastolic dysfunction.     

Effect of moxonidine hydrochloride on left ventricular hypertrophy in spontaneously hypertensive rats

AIM:To investate the effect of domestric moxonidine hydrochloride on myocardium fibrosis and coronary artery microvascular structure in left ventricular hypertrophy of spontaneously hypertensive rats(SHR).METHODS:30 male SHR, aged 20 weeks, were divided into group Mox+SHR, Cap+SHR and SHR randomly (10 in each group). 10 age and sex-mached sprauge-dawley rats were designed as normal control(NC). At the end of 13 weeks, left ventricular wight/body weight ratio(LVW/BW), collagen volume fraction(CVF) and standardized perivascular collagen area(PVCA) as well as intramyocardial arterial average medial thickness (AMT) were determined.RESULTS:LVW/BW, CVF, PVCA and AMT in group Mox+SHR were lower significantly than that in group SHR, respectively.CONCLUSION:Long-term antihypertensive treatment with moxonidine hydrochloride reduces myocardium fibrosis and improves impaired coronary artery microvascular structure in left ventricular hypertrophy.     

留守村民的健康分析——基于株洲市茶陵县马加村的调查

采用调查问卷和临床问诊的方法对湖南省株洲市马加村随机抽样的252名留守村民进行调查,共发放调查问卷264份,回收问卷252份,回收率95.5%。调查表明:81.7%的被调查者有不同程度的身体疾病,其中血压偏高者57.3%,长期肌肉疼痛者69.4%,关节、骨异常者52.9%,腰间盘突出者16%。在此基础上,对影响留守村民的健康的因素进行了分析。     

城市农民工子女融合困境与建议——基于农民工子女的城市融合与城市居民接纳态度之间的偏差

基于对江苏省苏州市、无锡市、南京市处于义务教育阶段的农民工子女及其家庭、城市居民的问卷调查,从农民工子女的城市就读情况、日常生活的市民化程度和身份认同等层面展开调查分析,重点考察农民工子女的城市融合与城市居民接纳度之间的偏差和不对等问题,分析问题产生的原因,提出相关建议,以期有效促进城市农民工子女的顺利融合。     

左右岸省界缓冲区水质达标评价方法研究

左右岸省界缓冲区作为协调省际间用水关系的重要水域,其水质达标评价及污染责任划分是流域限制纳污红线制度实施的重要内容。从左右岸省界缓冲区的相关概念出发,根据省份的位置关系将其分为缓冲区完全在两省省界上、缓冲区部分在两省省界上以及缓冲区在多省交界上三种情形,并结合左右岸省界缓冲区特点确定调整浓度核算法、代表断面判断法、限制排污总量-污染物入河量评估法等水质达标评价方法,以判断左右岸省份缓冲区的水质达标情况,从而划分缓冲区左右岸省份的污染责任。实例验证模拟显示,确定的方法切实可行,研究方法可为流域污染责任划分提供技术支撑,从而促进限制纳污制度的顺利实施。     

农村留守儿童问题行为状况调查与对策研究

对农村初中留守儿童问题行为的状况进行调查和分析,并提出相应的建议或干预措施。     

Evaluation of left ventricular function with cardiac magnetic resonance imaging and echocardiography after administration of dobutamine and esmolol in healthy beagle dogs

Unlike echocardiography, cardiac magnetic resonance imaging (cardiac MRI) results in a near-exact assessment of cardiac structures and function. However, most veterinary studies have focused on dogs with normal cardiac function. We hypothesized that there would be significant differences in cardiac measurements between cardiac MRI and echocardiography when left ventricular (LV) function was abnormal. This study was undertaken to compare measurements of LV function produced by cardiac MRI and echocardiography in dogs whose LV function was altered by pharmacological agents. This study was conducted with six healthy beagle dogs. We increased left ventricular contractility by administration of dobutamine; we decreased cardiac contractility with esmolol. Stroke volume measurements were made by using both cardiac MRI and echocardiography under seven different conditions with general anesthesia: control, three doses of esmolol (100, 200, and 500 µg/kg/min), and three doses of dobutamine (10, 20, and 50 µg/kg/min). Experiments involving each condition were conducted at least 1 week apart. When LV contractility was normal, ejection fraction (EF) and stroke volume (SV), as measured by echocardiography and cardiac MRI, were not significantly different. However, when contractility was changed by pharmacological agents, EF and SV were overestimated by echocardiography, compared to MRI. Evaluation of cardiac function in patients treated with pharmacological agents should be conducted carefully because EF and SV measured by echocardiography can be overestimated, compared with EF and SV obtained by cardiac MRI.     

The Stability of Quaternion Metrices and Their Judging Criteria

Some conceptions of stable quaternion matrices and some judging criteria are given.The Robrach theorem,Taussky theorem,Ostrowski Schneider theorem and Gerschgorin theorem are generalized to quaternion field.The conclusion about two quaternion matrices,i.e.,inferior positive matrices are unstable,interior negative matrices are stable and some other results are pointed out.     

农业转移人口子女语言状况与城市融合——以合肥市调查为例

农业转移人口子女进入城市后所面临的语码选择、家庭语言规划等语言问题与该群体的城市融合之间具有一定的相关性。对合肥两所小学的调查发现,普通话在该群体语言使用和家庭语言规划中具有较高的取向度,而合肥话与该群体的城市融合之间具有更强相关性。语言取向度高的原因在于合肥言语社区中普通话社区的互动人口和设施建设更加完善,而合肥话与城市融合的相关性更强则体现了语言认同在城市融合中的重要作用,也证明了提高城市方言取向度是促进城市融合的有效途径。