周期性测量方法探讨

本文就周期性测量中递推求精方法的可行性进行了一些探讨,并对两个典型实验推导出它们采用递惟求精方法的可行性判别式。     

《园艺学报》征稿简则

AIM:To investigate the prognostic value of biomarkers on predicting recurrence of hepatocellular carcinoma (HCC) after orthotopic liver transplantation (OLT). METHODS:Fifty patients with HCC who underwent OLT between April 2002 and November 2005 with a minimum clinical follow up of 12 months were included in this retrospective study. We examined immunohistochemical expression of E-cadherin with β-catenin, Ki-67 proliferative index and analyzed the correlation between these biomarkers with recurrence and survival, along with the main clinical-pathological variables.RESULTS:Only at univariate analysis, TNM, portal vein tumor thrombi were valuable on predicting recurrence and survival time (P<0.05), and preoperative serum AFP correlate to recurrence only at multivariate analysis (OR=2.552, P<0.05). Lower membrane expression of E-cadherin, nuclear β-catenin localization and high Ki-67 index showed notable significance on predicting recurrence and survival time at univariate analysis, as well at multivariate analysis, all P<0.01. The membrane expression of β-catenin did not correlate to the prognosis (P>0.05).CONCLUSION:These three biomarkers might have potential as a tumor prognostic marker for predicting recurrence of HCC after OLT and perhaps are better than the clinical-pathological variables.     

Analysis of risk factors associated with recurrence of canine babesiosis caused by Babesia gibsoni

Canine babesiosis due to Babesia gibsoni (B. gibsoni) displays severe clinical manifestations. Recurrence of babesiosis after anti-babesial treatment is observable in over 10 % of the patients. The present study ascertains the risk factors and cumulative incidence of recurrence of canine babesiosis. For a sample of 145 dogs diagnosed with acute babesiosis, the following parameters were assessed over a period of 16 weeks: haematological parameters, status of anaemia, platelet count, total WBC count, haemoglobin concentration and RBC count, concurrent haemoparasitism, and secondary immune mediated haemolytic anaemia (IMHA). Patient demographics such as age, breed, sex were also recorded. The potential risk factors were statistically evaluated by the cumulative incidence function and the Kaplan-Meier method. The recurrent infections were observed in 11.8 % of the study sample. The following factors were found to associate with increased risk of recurrence: Rottweiler breed (CIR 21.8 % ± 6.9 %; p < 0.05), secondary IMHA (CIR 28.7 % ± 11.3 %; p < 0.05), RBC counts < 2 × 10⁶/μl on the day of diagnosis (CIR 16 % ± 4.6 %; p < 0.05), and persistent anaemia over 20 days post treatment (CIR 29.14 ± 7.9 %; p < 0.001). Dogs with concurrent haemoparasitic infections were predicted to have a fatal outcome in the survival analysis (disease related mortalities 25 % ± 13 %; p < 0.001). According to the findings, veterinarians need to pay attention to Rottweiler breed, dogs with secondary IMHA, concurrent haemoparasitism, low RBC counts on diagnosis and those with persistent anaemia to reduce the risk of relapse.     

桃蛀螟对蓖麻的危害及其防治研究

[目的]控制桃蛀野螟对蓖麻的为害。[方法]对桃蛀野螟在蓖麻上的危害习性和发生规律进行试验观察。[结果]结果表明,补充营养对成虫产卵量影响明显,尤其是越冬代成虫。幼虫蛀食蓖麻果实、籽粒及雌雄花蕾,其他部位不取食。7～11月是此虫在蓖麻上的为害期,防治方法有药剂喷雾及套袋。[结论]该研究为蓖麻桃蛀野螟的防治提供科学依据。     

Use of Electrohydraulic Lithotripsy in 28 Dogs with Bladder and Urethral Calculi

Background: Electrohydraulic lithotripsy (EHL) has been used as an alternative to cystotomy in human medicine to remove urinary calculi. This prospective study evaluated the efficacy and safety of EHL to remove urinary calculi in dogs. Hypothesis: EHL is an efficient and safe method of treatment of bladder and urethral calculi in dogs. Methods: Dogs presented between January 1, 2005 and June 1, 2007 with lower urinary tract calculi diagnosed by radiographs or ultrasound examination were included in the study. Physical examination, CBC, biochemistry, urinalysis, and urine culture were performed at presentation. EHL and voiding urohydropulsion were performed under general anesthesia. Patients received IV fluids for 12 hours after which they were rechecked by ultrasound examination and discharged with antibiotics and anti‐inflammatory drugs for 5 days. All patients were reevaluated 1, 3, and 6 months after presentation by physical examination, urinalysis, and ultrasonography. Results: Twenty‐eight dogs (19 males, 9 females) presented with bladder or urethral calculi or both underwent lithotripsy. Their median weight was 8.3 kg. Calcium oxalate calculi were present in 22 dogs, struvite in 4, and mixed calculi in 2. Fragmentation was done in the bladder (23 dogs) and in the urethra (12 dogs). Calculus‐free rate was higher for urethral than for bladder calculi in males and higher for bladder calculi in females than in males. No major complications were reported. Twelve dogs relapsed within 6 months. Conclusions: Results of this study support the use of EHL as a minimally invasive treatment for bladder calculi in females and for urethral calculi in male dogs.     

Frequency–magnitude relationships for precipitation,stream flow and sediment load events in a small Mediterranean basin (Vallcebre basin,Eastern Pyrenees)

Precipitation, discharge and suspended sediment concentrations were continuously measured during 10 years (1995–2004), at the Ca l'Isard sub-basin (1.32 km²) of the Vallcebre experimental catchments. Daily precipitation record is 22 years long. When the ranks of the events obtained with the diverse variables considered (precipitation depth, peak discharge, runoff depth, suspended sediment concentration and sediment load) were compared, the results confirmed the complexity of the response of the catchment and demonstrated that precipitation is an irregular criterion for ranking the main sediment transporting events. When the partial duration series corresponding to the 10% major events were analysed, daily precipitation, peak discharge and sediment concentration series showed good fits with log-normal distributions, but event precipitation, runoff and sediment load series needed bi-modal log-normal distributions. This behaviour may be attributed to the fact that event mass magnitudes depend not only on event intensity but also on its duration.     

A clinical association between Toll-like receptor 2 Arg753Gln polymorphism with recurrent cystic echinococcosis in postsurgery patients: A case control study

Recurrence of hydatid cysts in cystectomy patients has dramatically remained a serious concern within the surgical community. Predisposing factors for recurrence of hydatid cysts remained to be identified. Toll-like receptor (TLR) plays a pivotal role in bridging between acquired and innate immunity in cystic echinococcosis (CE) infection. 117 CE patients including 66 acute hydatidosis (AH; primary infection) and 51 recurrent hydatidosis (RH; chronic infection), and 117 ethnically matched healthy control (HC) were investigated from endemic regions of Iran in the period of 2015–2018. CE patients were definitely confirmed using histopathological and immunological assays. Genotyping of TLR2 Arg753Gln was carried out by restriction fragment length polymorphism and sequencing. The homozygous mutant-type TLR2 Gln/Gln (A/A) was represented to be associated with the occurrence of RH (P = 0.04) and conferred a 9 fold risk for susceptibility, while the heterozygous mutant-type TLR2 Arg/Gln (G/A) indicated a tendency to be associated with the occurrence of RH (P = 0.07). There was no discrepancy in the frequency of TLR2 Arg753Gln haplotypes between AH patients and HC individuals (P = 0.09). The mutant allele A was observed to be a risk factor for susceptibility to RH patients. Our results point to a clinical association between TLR2 Arg753Gln haplotypes with RH in postoperative patients. It can be inferred that allele G may lead to protection against the CE, while mutant allele A may be a diagnostic hallmark in the screening of RH susceptibility. Nevertheless, further studies with a larger sample size of different ethnic populations are required to authenticate this association.     

Expression of macrophage migration-inhibitory factor in human recurrent cervical cancer tissues and its prognostic significance

AIM：To investigate the expression of macrophage migration-inhibitory factor (MIF) in human recurrent cervical cancer tissues and its influence on prognosis. METHODS：Eight-seven cases of recurrent cervical cancer were collected from January 2007 to December 2009 and followed up for at least 36 months. The MIF expression in cervical cancer tissues was tested by immunochemistry. RESULTS：The positive rate of MIF expression in recurrent cervical cancer was 75.7% (55/87). Compared with the patients with negative MIF expression, the patients with positive MIF expression showed worse response to antitumor therapy ［47.3% (26/55) vs 63.6% (21/32), P<0.05］ and shorter survival time (28.8 months vs 38.4 months, P<0.05). CONCLUSION：Positive MIF expression could be a risk factor in recurrence and prognosis of cervical cancer.