浅议《伤寒论》阴阳观

《伤寒论》中的阴阳观是仲景辨证论治体系的重要组成部分,笔者基于《伤寒论》原文的学习,从阴阳的动态比较、救阳存津的先后缓急、阳气阴形的相互为用等方面对其阴阳观进行探讨,认为阴阳谐和是《伤寒论》阴阳观的核心,并对“贵阳贱阴”的说法提出质疑。     

史锁芳教授运用“六经欲解时”辨治肺系疾病举隅

介绍史锁芳教授运用"六经欲解时"辨治肺系疾病经验。结合史教授临床病案咳嗽从"少阳、阳明欲解时"论治;发热、咳嗽先后从"阳明、太阴欲解时"论治;哮喘从"厥阴欲解时"论治,分析史老师运用"六经欲解时"的思路和方法,观察其临床疗效。运用"六经欲解时"辨治肺系病症疗效确切,"六经欲解时"理论具有积极的临床应用价值。     

《伤寒论》之经方煎服及调护方法浅谈

《伤寒论》中的方剂称为经方,至今在临床各科广泛应用,临床中辨证准确,应用疗效显著。但是现在应用其方往往有不如意者,究其缘由,往往是煎服及调护法不对。故而梳理《伤寒论》之经方煎服及服药后调护法整理如下,以期指导临床实践,提高临床疗效。     

从人体阴阳本体结构谈谈对《伤寒论》六经实质的认识

本文以人体阴阳本体结构为主线,辅以八纲辨证与标本两端,从《伤寒论》六经病“欲解时”入手,对六经的时相变化以及六经病提纲证与代表方作出了诠释,从而使六经的实质得以阐明,即六经乃是人体一阴一阳在内阳外阴本体结构范围内的不同时区的六种不同的气化形式或气化单元,亦称“六经时相”。并认为六经实质能如此直接认定,不需它求,根本在于《伤寒论》六经的提出与人体内阳外阴本体结构遵循着中医理论共同的基本原理,即阴阳运动的一致性与交感性;还在于张仲景将六经阴阳的气化交感运动与阴阳四时的生长收藏变化直接对应起来,而人体阴阳本体结构正是作为如实反映阴阳的四时消息变化的一个定式而提出的,故能两两相契。     

Clinical Presentation,Progression, and Management of Five Cases of Ross River Virus Infection in Performance Horses Located in Southeast Queensland: A Longitudinal Case Series

Ross River virus (RRV), a mosquito-transmitted alphavirus prevalent in Australia, is believed to cause poor performance, lethargy, and muscle stiffness in Australian horses. However, disease progression and management is poorly documented. A better understanding of disease presentation, acute therapy, and long-term management is required. The aim of the study was to describe clinical presentation, diagnosis, acute treatment, and long-term management of RRV infection in horses. This study is a series of retrospective case reports. Clinical and diagnostic data were obtained from both veterinary records, and owner interviews for five performance horses that presented with acute poor performance coupled with serologic evidence of RRV exposure. Clinical and owner reports were evaluated from the time of presentation until the horses appeared asymptomatic and had returned to normal performance. Ross River virus was suspected to be the cause of generalized muscle stiffness and poor performance in five performance horses located in southeast Queensland between 2011 and 2015. Clinical symptoms included pyrexia, tachypnea, exercise intolerance, generalized muscle stiffness, synovial effusion, and edema of the lower limbs. Serologic investigations (ELISA and/or virus neutralization assay) detected antibody responses to RRV. Horses were treated with nonsteroidal anti-inflammatory drugs (n = 5) and disease-modifying osteoarthritis drugs (n = 2). Most horses returned to previous athletic capabilities between 7 and 12 months after the onset of symptoms. Not all horses in the study had preclinical serology or submitted paired blood samples for serology, meaning assumption of acute infection in those horses was made based on clinical signs coupled with positive serology. Ross River virus is a significant but poorly understood cause of poor performance in Australian horses. This report is the only one to document longitudinal management of performance horses affected by RRV infection. Much more research is needed to gain a better understanding of this infection in horses.     

土霉素对正常、沙门氏菌内毒素引起发热猪的药代动力学研究

以高效液相色谱法作为血液中土霉素含量的检测方法,研究了单次静注土霉素(20mg/kg)后在正常和沙门氏菌内毒素引起发热猪体内的动力学行为。结果表明,土霉素在正常猪体内适合无吸收三室开放模型,而在发热猪体内适合无吸收二室开放模型,发热改变了土霉素在猪体内的动力学行为。在正常猪,其消除半衰期(t0.5β)和总体消除率(CLB)分别为6.40h和0.174L/kg·h,在发热猪,则分别为6.13h和0.109L/kg·b.以1μg/ml的土霉素血清浓度为最小有效浓度,求出的维持有效浓度时间为20.34h和26.42h。并根据求出的药动学参数,推荐了一个给药方案。