Approaches to Configuration Determinations of Flexible Marine Natural Products: Advances and Prospects

Flexible marine natural products (MNPs), such as eribulin and bryostatin, play an important role in the development of modern marine drugs. However, due to the multiple chiral centers and geometrical uncertainty of flexible systems, configuration determinations of flexible MNPs face great challenges, which, in turn, have led to obstacles in druggability research. To resolve this issue, the comprehensive use of multiple methods is necessary. Additionally, configuration assignment methods, such as X-ray single-crystal diffraction (crystalline derivatives, crystallization chaperones, and crystalline sponges), NMR-based methods (JBCA and Mosher’s method), circular dichroism-based methods (ECCD and ICD), quantum computational chemistry-based methods (NMR calculations, ECD calculations, and VCD calculations), and chemical transformation-based methods should be summarized. This paper reviews the basic principles, characteristics, and applicability of the methods mentioned above as well as application examples to broaden the research and applications of these methods and to provide a reference for the configuration determinations of flexible MNPs.     

Use of hinged circular fixator constructs for the correction of crural deformities in three dogs

Background Hinged circular external skeletal fixator constructs are used to perform sequential correction of angular limb deformities, often with resultant limb segment lengthening, via distraction osteogenesis. Although there are several reports describing the use of these constructs for correction of antebrachial deformities in dogs, there is little information regarding their use on other limb segments. This report describes the use of hinged circular fixator constructs for the correction of acquired crural deformities in three skeletally immature dogs. Case reports Two dogs had purely frontal plane deformities (one valgus, one varus) and the third dog had frontal (valgus) and sagittal (recurvatum) components to its deformity. At the time of long‐term evaluation, frontal plane angulation relative to the contralateral limb improved from 40° to 22° of valgus, 30° to 5° of valgus, and 20° to 1° of varus in the three individual dogs. Tibial length discrepancies of 12% and 22% that were initially present in two dogs were improved to 6% and 10%, respectively, of the contralateral tibial length at the time of final evaluation; both dogs had compensatory growth of the ipsilateral femur and all dogs had an excellent functional outcome. Conclusion These cases illustrate the value of using hinged circular fixator constructs for correction of crural angular deformities, particularly when length discrepancies of the tibia are present.     

层次分析法在畜牧业循环经济综合评价中的应用

对畜牧业实行循环经济的综合评价是衡量畜牧业可持续发展程度的重要措施。采用层次分析法的原理建立畜牧业循环经济综合评价的数学模型,对层次分析法的具体流程进行详细描述,同时对层次分析法存在的一些问题进行总结。通过相应的实例,证明层次分析法在畜牧业循环经济综合评价中应用的可行性,对畜牧业相关部门在制定政策时能起到决策支持的作用。     

循环经济理念下绿色饲料产业的机遇和挑战

传统经济对工业进步的推动作用不可小觑,但这种传统的经济理念在改变人们生活方式的同时也带来了资源的破坏.这种环境和经济发展不平衡的现象影响了未来人类的生存环境与经济发展方式.对此,建立循环经济理念,以可持续的资源保护方式推动产业发展,走资源循环路线非常重要.本文从循环经济的理论基础着手,探讨了循环经济与绿色饲料产业之间的...     

面向循环经济的畜禽养殖发展思路

本文阐述了循环经济的特征及其运行模式，分析了传统畜禽养殖业的污染现状及其原因，讨论了面向循环经济的畜禽养殖业应遵循的三大原则，即减量化、再利用和资源化，对畜禽养殖技术、废物利用技术进行了探讨，提出畜禽养殖业应该走循环经济的发展模式，通过研制生态饲料及废物综合利用，达到畜禽粪便的减量化、资源化和无害化。     

南方规模化奶牛场草基循环农业模式研究

针对奶牛养殖快速发展带来的资源浪费和环境污染问题,探讨了南方规模化奶牛场循环农业模式并提出了相关策略。提出养殖场粪污(包括奶牛粪、尿和养殖废水)是造成环境污染的主要因子,牧草是消纳养殖场粪污,变废为宝,构成循环利用链的主要载体。因此南方规模化奶牛养殖可以就地取材、就近利用,构筑形成草基循环农业模式。草基循环农业模式结合规模化奶牛养殖对鲜草需要量大、杂交狼尾草产量高且对奶牛场污水氨氮吸收率高的三大因素而构建,是低耗高效、安全优质、清洁生态的循环农业模式。     

家兔胸部X线体层摄影技术的实验研究

选用健康家兔40只,取仰卧位保定,5％戊巴比妥钠溶液麻醉,对家兔胸部体层摄影技术进行了探讨。几何条件:使用直线轨迹时,曝光角度以20°为好;使用区域圆轨迹时,以12°为好。显示支气管的最佳层次()与胸厚(X)的回归方程(?)=0.739X-1.922。物理条件:kVP=胸厚(cm)+40+10(滤线器);mA及s:直线轨迹时100mA,0.3s;区域圆轨迹时20mA,2.8s。并对所拍摄的X线体层照片进行了分析,在显示胸部某一层面的结构上和对肺脏、支气管部位病变的诊断上,体层摄影有明显的优点,而麻醉对改善体层片的质量有一定作用。     

圆形截面钢筋砼偏心受压构件正截面承载力的实用计算法

本文根据《砼结构设计规范》（ＧＢＪ１０－８９）对圆形截面钢筋砼偏心受压构件正截面承载力的计算方法进行了分析，编制了计算图表，供设计者直接查用．该法计算简便、速度快、精度高，有一定的实用价值．     

硬质合金圆锯片的噪声及其降低措施

分析了硬质合金圆锯片的噪声来源、锯片噪声测量方法及降低噪声的措施,通过试验验证了降噪措施的可行性。