食品工厂设备清洗系统CIP的原理与发展前景

食品加工企业在产品生产过程中,加工设备及管道的清洗非常重要。加工设备及管道在使用后会产生一些沉积物,如不及时、彻底地清洗,将直接会影响产品的质量。原地清洗系统(CIP)是一种理想的设备及管道清洗方法,目前在食品加工企业,特别在乳制品企业中的应用越来越广泛,论述了CIP设备的原理及其清洗剂的清洗效果。     

中美图书在版编目的比较和借鉴

阐述了在版编目的基本概念,从发展进程、印刷位置、制作机构、制作流程、著录格式等角度,对中美两国的CIP进行了比较,总结了我国CIP存在的问题,借鉴美国CIP的经验,来改进我国CIP今后的工作。     

p21WAF1/CIP1蛋白在小鼠卵泡与黄体中的表达

【目的】研究p21WAF1/CIP1蛋白在成年小鼠卵泡发育与黄体形成及退化过程中表达的变化规律。【方法】取20只成年雌性小鼠的卵巢,制作石蜡切片,经免疫组织化学SP法染色后,观察p21WAF1/CIP1蛋白在原始卵泡、初级卵泡、次级卵泡、三级卵泡、成熟卵泡、闭锁卵泡、早期黄体、中期黄体以及晚期黄体中的定位及表达。【结果】卵泡发育和黄体形成及退化过程中均有p21WAF1/CIP1蛋白的表达;p21WAF1/CIP1蛋白在此过程中呈先升高后降低的趋势,峰值出现在三级卵泡时期。【结论】p21WAF1/CIP1蛋白在卵母细胞中发挥一定作用,可能参与优势卵泡的选择,并对卵泡发育及黄体形成和退化有影响。     

食品工厂设备清洗系统CIP的原理与发展前景

食品加工企业在产品生产过程中,加工设备及管道的清洗非常重要。加工设备及管道在使用后会产生一些沉积物,如不及时、彻底地清洗,将直接会影响产品的质量。原地清洗系统（CIP）是一种理想的设备及管道清洗方法,目前在食品加工企业,特别在乳制品企业中的应用越来越广泛,论述了CIP设备的原理及其清洗剂的清洗效果。     

国际马铃薯中心(CIP)在中国马铃薯晚疫病研究概况

国际马铃薯中心在中国设立的研究项目主要集中在抗晚疫病材料的引进、评价和利用；晚疫病菌生物学特性的研究及晚疫病的综合防治研究。自中国与国际马铃薯开展科技合作以来，已引进了近300份抗晚疫病的马铃薯种质资源，包括杂交种子、试管苗和薯块。从中筛选出了一些可直接用于生产的抗晚疫病材料，从引进的杂交实生种子组合中也筛选出了一些新的品种，并利用这些资源与国内品种资源进行杂交，从中培育了新的抗性品种，极大地减轻了晚疫病对我国马铃薯生产的影响。为研究晚疫病菌的生物学特性及其对瑞毒霉的抗性，从国内马铃薯主产省区收集了200多个菌株，并对生理小种和抗药进行鉴定，所保存的菌株为进一步研究晚疫病打下了良好的基础。以利用马铃薯品种抗性为基础的综合防治研究工作已开始在中国进行，重点放在基因与环境的互作、预测预报和特定农业生态区综合防治配套技术上。     

CIP清洗系统的设计及注意事项

CIP清洗系统在食品、饮料、生物制药、化工,特别是在乳品工业生产中应用广泛。采用自动CIP清洗系统的企业也越来越多,但CIP清洗系统在应用中也存在一些问题,就此从设计及应用上对其设计过程及注意事项进行阐述。     

Activation of the Tumor Suppressor PP2A Emerges as a Potential Therapeutic Strategy for Treating Prostate Cancer

Protein phosphatase 2A (PP2A) is a tumor suppressor complex that has recently been reported as a novel and highly relevant molecular target in prostate cancer (PCa). However, its potential therapeutic value remains to be fully clarified. We treated PC-3 and LNCaP cell lines with the PP2A activators forskolin and FTY720 alone or combined with the PP2A inhibitor okadaic acid. We examined PP2A activity, cell growth, prostasphere formation, levels of PP2A phosphorylation, CIP2A and SET expression, and AKT and ERK activation. Interestingly, both forskolin and FTY720 dephosphorylated and activated PP2A, impairing proliferation and prostasphere formation and inducing changes in AKT and ERK phosphorylation. Moreover, FTY720 led to reduced CIP2A levels. Treatment with okadaic acid impaired PP2A activation thus demonstrating the antitumoral PP2A-dependent mechanism of action of both forskolin and FTY720. Levels of PP2A phosphorylation together with SET and CIP2A protein expression were studied in 24 PCa patients and both were associated with high Gleason scores and presence of metastatic disease. Altogether, our results suggest that PP2A inhibition could be involved in PCa progression, and the use of PP2A-activating drugs might represent a novel alternative therapeutic strategy for treating PCa patients.     

Pyramiding of insecticidal compounds for control of the cowpea bruchid (Callosobruchus maculatus F.)

The cowpea bruchid (Callosobruchus maculatus F.) (Chrysomelidae: Bruchini) is a major pest of stored cowpea grain. With limited available technologies for controlling the bruchid, transgenic cowpeas with bruchid resistance genes engineered into them could become the next management tools. An investigation was made of two different sets of potential transgenic insecticidal compounds using an artificial seed system: (i) CIP-PH-BT-J and recombinant egg white avidin, and (ii) avidin and wheat alpha-amylase inhibitor. CIP-PH-BT-J (0.1%; 1000 mg kg(-1)) and recombinant egg white avidin (0.006%; 60 mg kg(-1)) incorporated separately into artificial seeds caused 98.2 and 99% larval mortality rates respectively. Combining CIP-PH-BT-J and avidin in the same artificial seed provided additional mortality compared with each factor incorporated singly; no insects survived in seeds with the combined toxins. Similarly, when avidin and wheat alpha-amylase inhibitor (alphaAI) (1%; 10 g kg(-1)) were incorporated separately into artificial seeds, this caused 99.8 and 98% mortality respectively. However, in combination, avidin and alphaAI did not increase mortality, but they did cause a significant increase in developmental time of the cowpea bruchids. These results emphasize that the joint action of potential insecticidal compounds cannot be predicted from results obtained separately for each compound, and they suggest potential transgenes for further consideration.     

合理利用医学图书CIP数据，提高书目数据标准化

概述了在版编目的发展,从医学类图书CIP数据的分类标引、主题标引和著录数据三方面分析了医学图书在版编目数据存在的问题,并对提高CIP数据质量和图书馆书目数据标准化规范化程度提出一些建议。