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施德昌 《南京农业大学学报》1989,12(1):118-128
本文提出了串励直流电动机使用新型无触点斩波调速的新方法。通过两组二段式斩波电路,主电路完全无触点化成为可能,而且扩大了调速使用范围,也证明了可应用于双机车牵引同步自动化控制。 相似文献
3.
张方明 《甘肃农业大学学报》1996,(2)
通过对博士研究生特点的综合分析,在教学实践中强化三个主要环节,探索了适合博士生特点,反映课程要求的教学方法。 相似文献
4.
Although the molluscicide Frescon is a strong neurotoxin to the Lymnaea stagnalis central nervous system in vitro, it is probable that the exposure of the whole animal to this molluscicide fails to result in central nervous system abnormalities: Frescon does not appear to reach the brain in sufficient quantity to disrupt its normal activity. However, only those Frescon analogs found to be neurotoxic were molluscicidal, suggesting some related mode, if not site, of action. Frescon and its analogs may act by affecting excitable tissues other than the nervous system (e.g., the snail musculature) by altering certain functional and/or structural membrane properties. 相似文献
5.
通过12a大田长期定位试验研究了在自然降水条件、冬小麦—大豆轮作(或休闲)种植制度下,0~400cm土娄土剖面硝态氮分布与积累的特点。结果表明,长期单施氮肥,氮的表观利用率特别低,仅0.51%,氮肥配施钾、磷肥,氮的表观利用率为25%~35%,氮磷钾平衡施肥及配施有机肥,氮的表观利用率达到50%;施N肥方式显著影响土壤硝态氮积累和淋移,旱地土娄土长期单施化学氮肥或氮钾、氮磷、氮磷钾肥使土壤NO-3-N大量积累和淋移;氮磷钾与有机肥的配合施用能有效地缓解土壤对硝态氮的积累,提高氮肥利用率。 相似文献
6.
为了进一步研究前期发现的除草先导化合物2-仲丁氨基-5-(2-氯吡啶-4-基)-1,3,4-噻二唑(BCPT)的结构-活性关系并提高其除草活性,设计并合成了一系列N-(1-甲氧羰基)乙基-N-[5-(2-氯吡啶-4-基)-1,3,4-噻二唑-2-基]酰胺类化合物。其苗后除草活性测定结果表明,所有化合物的活性都远低于BCPT本身。说明BCPT可能具有与传统酰胺类除草剂不同的作用机制。 相似文献
7.
油菜多室角果是一种高产相关性状,本研究对桑日白油菜(srb)多室性状的遗传调控机制进行研究。性状分析表明,该突变体具有稳定的多室角果表型,单株多室角果比例为94.7%~100.0%,每角果平均3.5个心皮。遗传上srb突变体中的多室性状受1对隐性核基因控制。比较测序分析发现, srb中BrCLV3基因的CLE motif中存在一种新的单核苷酸突变(C/G),可导致其保守结构域的第12位组氨酸突变为天冬氨酸,将该位点命名为Brclv3Asp12。利用SNP标记进行分离群体的鉴定,证实Brclv3Asp12中的C/G单核苷酸变异与多室表型共分离。转基因互补测验和体外多肽的处理试验进一步证实,该材料中控制多室性状位点Brclv3Asp12突变导致了CLV3多肽活性的减弱,是形成多室角果性状的原因。本研究初步阐明了白菜型油菜srb多室性状形成的机制。 相似文献
8.
Jianjiang Li Ningning Han Hao Zhang Xiaoyu Xie Yaoyao Zhu E Zhang Jiahui Ma Chuangeng Shang Mengxiong Yin Weidong Xie Xia Li 《Marine drugs》2022,20(9)
Moromycin B (Mor B), saquayamycin B1 (Saq B1), saquayamycin B (Saq B), and landomycin N (Lan N), four angucyclines produced by the marine-derived actinomycete Streptomyces sp., are a class of polyketone compounds containing benzanthracene. Here, the structure–activity relationship of these four compounds was analyzed in human colorectal cancer (CRC) cells. Saq B1, which showed the strongest cytotoxicity with an IC50 of 0.18–0.84 µM for CRC cells in MTT assays, was employed to test underlying mechanisms of action in SW480 and SW620 cells (two invasive CRC cell lines). Our results showed that Saq B1 inhibited CRC cell proliferation in a dose- and time-dependent manner. Notably, lower cytotoxicity was measured in normal human hepatocyte cells (QSG-7701). Furthermore, we observed proapoptosis, antimigration, and anti-invasion activities of Saq B1 in CRC cells. At the same time, the protein and mRNA expression of important markers related to the epithelial–mesenchymal transition (EMT) and apoptosis changed, including N-cadherin, E-cadherin, and Bcl-2, in Saq B1-treated CRC cells. Surprisingly, the PI3K/AKT signaling pathway was shown to be involved in Saq B1-induced apoptosis, and in inhibiting invasion and migration. Computer docking models also suggested that Saq B1 might bind to PI3Kα. Collectively, these results indicate that Saq B1 effectively inhibited growth and decreased the motor ability of CRC cells by regulating the PI3K/AKT signaling pathway, which provides more possibilities for the development of drugs in the treatment of CRC. 相似文献
9.
Lena Stiefvatter Konstantin Frick Katja Lehnert Walter Vetter Alexander Montoya-Arroyo Jan Frank Ulrike Schmid-Staiger Stephan C. Bischoff 《Marine drugs》2022,20(11)
Dietary supplements that promote healthy aging are mostly warranted in an aging society. Because of age-related risks, anti-inflammatory and anti-oxidative agents such as microalgae are potential candidates for intervention. In a randomized controlled trial, we tested Phaeodactylum tricornutum (PT), a microalgae rich in eicosapentaenoic acid (EPA), carotenoids, vitamins, and β-glucans, cultured in bioreactors. In this pilot trial, 19 healthy elderly received supplements for two weeks based on either the whole PT (A), the β-1,3-glucan-rich PT supernatant (SupB), the combination thereof (A+SupB), or a Comparator product (Comp). The primary outcome variable plasma interleukin-6 was reduced after treatment with A+SupB compared to the Comp group (p = 0.04). The mobility parameters 5 s sit-to-stand test (p = 0.04 in the A group) and by trend gait speed (p = 0.08 in the A+SupB diet) were improved compared to Comp. No treatment effects were observed for fatty acids, compared to Comp but omega-6 to -3 fatty acid ratio (p = 0.006) and arachidonic acid/EPA ratio (p = 0.006) were reduced within group A+SupB. Further, the SupB study product reduced faecal zonulin (p = 0.03) compared to the Comp. The data revealed an anti-inflammatory and potentially anti-oxidative effect of particular PT preparations, suggesting that they might be suitable for effects in healthy elderly. 相似文献
10.