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M. Borgarelli O. Lanz N. Pavlisko J.A. Abbott G. Menciotti M. Aherne S.M. Lahmers K.K. Lahmers J.S. Gammie 《Journal of Veterinary Cardiology》2017,19(3):256-267
Objective
Mitral valve (MV) regurgitation due to degenerative MV disease is the leading cause of cardiac death in dogs. We carried out preliminary experiments to determine the feasibility and short-term effects of beating-heart MV repair using an expanded polytetrafluorethylene (ePTFE) chordal implantation device (Harpoon TSD-5) in dogs.Animals
This study involved six healthy purpose-bred Beagles (weight range 8.9–11.4 kg).Material and methods
Following a mini-thoracotomy performed under general anesthesia, the TSD-5 was used to place 1 or 2 artificial ePTFE cords on the anterior MV leaflet or the posterior MV leaflet via a left-ventricular transapical approach. The procedure was guided and monitored by transesophageal echocardiography. Postoperative antithrombotic treatment consisted of clopidogrel or a combination of clopidogrel and apixaban. Dogs were serially evaluated by transthoracic echocardiography at day 1, 7, 14, 21, and 30. The hearts were then examined for evaluation of tissues reactions and to detect signs of endothelialization.Results
One or two chords were successfully implanted in five dogs. Four dogs completed the 30 days follow-up. One dog died intra-operatively because of aortic perforation. One dog died early post-operatively from a hemorrhagic pleural effusion attributed to overly aggressive antithrombotic treatment. One dog developed a thrombus surrounding both the knot and the synthetic cord. Postmortem exam confirmed secure placement of ePTFE knots in the mitral leaflets in all dogs and the presence of endothelialization of the knots and chords.Conclusions
These preliminary results demonstrate the feasibility of artificial chordal placement using an ePTFE cordal implantation device in dogs. 相似文献2.
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六种阔叶木CTMP制浆性能的初步研究 总被引：2，自引：0，他引：2
对拟赤杨等６种阔叶木进行纤维形态和化学组成的测定、ＣＴＭＰ制浆、打浆强度分析及漂白工艺的研究，结果表明拟赤杨等几种阔叶木具有较好的制浆适应性。 相似文献
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