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1.
Loida O. Casalme Keisuke Katayama Yoshiki Hayakawa Kensuke Nakamura Arisa Yamauchi Yasuyuki Nogata Erina Yoshimura Fuyuhiko Matsuda Taiki Umezawa 《Marine drugs》2022,20(2)
Some derivatives of dolastatin 16, a depsipeptide natural product first obtained from the sea hare Dolabella auricularia, were synthesized through second-generation synthesis of two unusual amino acids, dolaphenvaline and dolamethylleuine. The second-generation synthesis enabled derivatizations such as functionalization of the aromatic ring in dolaphenvaline. The derivatives of fragments and whole structures were evaluated for antifouling activity against the cypris larvae of Amphibalanus amphitrite. Small fragments inhibited the settlement of the cypris larvae at potent to moderate concentrations (EC50 = 0.60-4.62 μg/mL), although dolastatin 16 with a substituent on the aromatic ring (24) was much less potent than dolastatin 16. 相似文献
2.
Toyokazu KOBAYASHI Hiroshi KOIE Arisa WATANABE Arisa INO Kazuya WATABE Mujo KIM Kiichi KANAYAMA Kazuya OTSUJI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(4):503-506
We examined the effects of chicken egg hydrolysate (also known as “bone peptide” or BP)
on bone metabolism in 5- to 8-month-old orchidectomized dogs. The bone formation marker
serum bone alkaline phosphatase (BAP) and the bone resorption marker urine
deoxypyridinoline (DPD) were used as indicators to measure changes in bone metabolism. The
following results were observed that Serum BAP was higher in dogs fed BP-enriched food
throughout the clinical investigation. Serum BAP was statistically significantly higher in
dogs fed BP-enriched food than in dogs fed non-BP-enriched food at 2 months after
orchidectomy. This suggests that BP promoted bone formation immediately after
orchidectomy. 相似文献
3.
Hiromitsu Kisanuki Arisa Nakai Akiko Nadamoto Masako Wakino 《Journal of Forest Research》2009,14(6):342-348
We determined patterns of microsite suppression in dwarf bamboo Sasa nipponica when grazing deer were absent. This bamboo species is able to outcompete Hondo spruce (Picea jezoensis var. hondoensis) saplings under many environmental circumstances. We set up two 10 × 100 m plots inside a deer-proof fence within a subalpine
forest on Mt. Ohdaigahara, central Japan, and two similarly sized plots outside the fence. Within the plots, we surveyed microsites
where spruce saplings grew. We measured height and shoot elongation of all spruce saplings, and culm height and cover ratios
of dwarf bamboo growing around each spruce sapling. Spruce sapling density and average height were higher inside the deer-proof
fence than outside, as were bamboo height and cover. Thus, there was a negative effect of deer browsing on vegetation parameters
outside the fence and a suppression of the negative effect of bamboo on spruce sapling growth inside the fence. Spruce sapling
height was higher in tree-fall pits than in other microsites inside the fence, whereas both dwarf bamboo height and cover
were lower in pits and rocky sites than elsewhere. In soil and collar microsites, spruce sapling shoot growth was lower and
bamboo height and cover were higher than in pits and rocky sites. Inside the fence, dwarf bamboo cover was high, but pits
and rocks suppressed its growth, allowing spruce saplings to flourish. To restore heavily damaged spruce forests with advanced
saplings, it will be necessary to construct deer-proof fences and create and maintain microsites with pits and rocks. 相似文献
4.
Hiromitsu Kisanuki Hisae Oguro Arisa Nakai Suzuki Setsuko Naoyuki Nishimura Nobuhiro Tomaru 《Journal of Forest Research》2008,13(2):143-146
We studied seed bank formation of the threatened star magnolia, Magnolia stellata, to examine the early stage of regeneration. Forty-five seedling plots (2 × 2 m), each including a soil-sampling quadrat
(40 × 40 cm), were established randomly under or around the crowns of mature M. stellata trees. Seeds of M. stellata were collected from each quadrat to a depth of 5 cm. Only four seeds of M. stellata were found (0.56 seeds/m2) and all were located under mature crowns. Current-year seedlings were abundant in water channels, on moss, or under mature
crowns, suggesting that the seeds may require wet soil conditions for germination. Magnolia stellata seeds show considerable germination below the crowns of mature trees in the year following masting, while some seeds remain
dormant in the soil. Considering the soil seed bank and the current-year seedling bank of M. stellata, a frequent supply of seed is essential for the regeneration of this species. Thus, it is important to maintain mature trees
in addition to promoting seed production. 相似文献
5.
Taiki KIDA Arisa YAMAZAKI Koji KOBAYASHI Tatsuro NAKAMURA Takayuki NAKAGAWA Ryohei NISHIMURA Takahisa MURATA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(5):644
Polyunsaturated fatty acids, including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA), are converted to hundreds of lipid mediators by cyclooxygenases (COX), lipoxygenases (LOX), and cytochrome P450 (CYP), or through non-enzymatic processes, and they reflect inflammatory states of the body. We comprehensively analyzed lipid metabolites in dog urine using a liquid chromatograph-mass spectrometry (LC-MS/MS) to describe their metabolic characteristics. We detected 31 AA-derived metabolites, four EPA-derived metabolites, and a DHA-derived metabolite in all urine samples. Among AA-derived metabolites, 15, 5, 3, and 8 were generated by COX, LOX, CYP, and non-enzymatic oxidation respectively. This study will be the first step to use profiles of urinary lipid metabolites for better understanding and diagnosis of canine diseases. 相似文献
6.
7.
Arisa MUNETOMO Hirotaka ISHII Takenori MIYAMOTO Yasuo SAKUMA Yasuhiko KONDO 《The Journal of reproduction and development》2016,62(1):17-27
In the rat, induction of maternal behavior depends on the parity of the female. For example, nulliparous
(NP) females need longer exposure to pups than multiparous (MP) or lactating (L) females to exhibit similar
maternal behavior. In this study, we investigated the role of brain oxytocin in the approaching behavior of
these female rats. Olfactory preferences for pup odors were examined for 8 consecutive days. Each preference
test was followed by direct overnight exposure to pups. On the 8th day, MP and L, but not NP females showed
robust pup-odor preferences. After the behavioral test, half of the females were exposed to pups for 2 h,
whereas the other half were not. The females were then sacrificed to analyze brain oxytocin (OXT) and
vasopressin (AVP) activities by cFos immunohistochemistry and to quantify their receptor mRNA expression using
real-time PCR. In the paraventricular nucleus (PVN), the percentage of cFos-positive OXT neurons was
significantly larger in MP and L females than in NP females after pup exposure. No significant differences
were found in cFos expression in OXT neurons of the supraoptic nucleus (SON) or in AVP neurons of either the
PVN or SON. Expression of OXT receptor mRNA in the medial preoptic area and amygdala of the control groups was
also higher in MP females than in NP females. Finally, we demonstrated that infusion of OXT into the lateral
ventricle of NP females promoted preferences for pup odors. These results indicate that puerperal and parental
experiences enhance the responsiveness of OXT neurons in the PVN to pup stimuli and establish olfactory
preferences for these odors in a parity-dependent manner. 相似文献
8.
Yutaka Taguchi Yudai Inabu Koki Hayasaki Noriyuki Maeda Yoshiro Kanmera Seiji Yamasaki Noboru Ota Kenji Mukawa Arisa Tsuboi Hirokuni Miyamoto Tetsuji Etoh Yuji Shiotsuka Ryoichi Fujino Christopher D. McMahon Hideyuki Takahashi 《Animal Science Journal》2021,92(1):e13505
We evaluated the effects of feeding high volumes of milk replacer on growth and reproductive performances in Japanese black heifers. Fifty-one heifers were fed milk replacer at 9 L/day for 60 days (9 L × 60 days; n = 18) or 41 days (9 L × 41 days; n = 15), or at 7 L/day for 40 days (7 L × 40 days; n = 18). Artificial insemination (AI) was performed on heifers with ≥270 kg body weight and ≥116 cm body height at 300 days of age. The age at the first AI was 0.35 month later for 7 L × 40 days than the other groups (p < .01). However, age at calving did not differ among treatments (22.1 months). The interval from the first AI to pregnancy tended to be ~2 months longer for the 9 L × 60 days than the other groups (p = .07). Our results showed that feeding high volumes of milk replacer may reduce the age at calving via an improved rate of growth. In addition, we propose that feeding a maximum of 7 L milk replacer for 40 days may be the most appropriate rearing regime because the success of pregnancy per AI may be reduced in calves fed a maximum of 9 L for 41 and 60 days. 相似文献
9.
To clarify the effects of inundation on the establishment of Salix gracilistyla trees, the relationship between total inundation duration and the distribution and size of trees was examined on a gravel
bar along the Miya River in central Japan. The density of S. gracilistyla was low at both low and high elevations on the gravel bar, but high at middle elevations. The density increased with up to
165 days of inundation and declined gradually with more than 165 days of inundation. Density had a negative effect on crown
area, whereas inundation duration had a positive effect. At lower elevations, growth limitation of S. gracilistyla is mainly caused by inundation stress, whereas at higher elevations it seems to be primarily due to drought stress, although
it depends on the total duration of inundation in a year (TDIY). Consequently, the density is highest at middle elevations
where trees do not become too large. These results suggest that inundation duration is one factor determining the density
of S. gracilistyla trees, which in turn affects the size of each tree. 相似文献
10.
Arisa SUGIMOTO Hitomi TSUCHIDA Mayuko NAGAE Naoko INOUE Yoshihisa UENOYAMA Hiroko TSUKAMURA 《The Journal of reproduction and development》2022,68(3):190
Reproductive function is suppressed during lactation owing to the suckling-induced suppression of the kisspeptin gene (Kiss1) expression in the arcuate nucleus (ARC) and subsequent suppression of luteinizing hormone (LH) release. Our previous study revealed that somatostatin (SST) neurons mediate suckling-induced suppression of LH release via SST receptor 2 (SSTR2) in ovariectomized lactating rats during early lactation. This study examined whether central SST-SSTR2 signaling mediates the inhibition of ARC Kiss1 expression and LH release in lactating rats during late lactation and whether the inhibition of glutamatergic neurons, stimulators of LH release, is involved in the suppression of LH release mediated by central SST-SSTR2 signaling in lactating rats. A central injection of the SSTR2 antagonist CYN154806 (CYN) significantly increased ARC Kiss1 expression in lactating rats on day 16 of lactation. Dual in situ hybridization revealed that few ARC Kiss1-positive cells co-expressed Sstr2, and some of the ARC Slc17a6 (a glutamatergic neuronal marker)-positive cells co-expressed Sstr2. Furthermore, almost all ARC Kiss1-positive cells co-expressed Grin1, a subunit of N-methyl-D-aspartate (NMDA) receptors. The numbers of Slc17a6/Sstr2 double-labeled and Slc17a6 single-labeled cells were significantly lower in lactating dams than in non-lactating rats whose pups had been removed after parturition. A central injection of an NMDA antagonist reversed the CYN-induced increase in LH release in lactating rats. Overall, these results suggest that central SST-SSTR2 signaling, at least partly, mediates the suppression of ARC Kiss1 expression and LH release by inhibiting ARC glutamatergic interneurons in lactating rats. 相似文献