排序方式: 共有1条查询结果,搜索用时 15 毫秒
1
1.
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene 总被引:1,自引:0,他引:1
Duerr RH Taylor KD Brant SR Rioux JD Silverberg MS Daly MJ Steinhart AH Abraham C Regueiro M Griffiths A Dassopoulos T Bitton A Yang H Targan S Datta LW Kistner EO Schumm LP Lee AT Gregersen PK Barmada MM Rotter JI Nicolae DL Cho JH 《Science (New York, N.Y.)》2006,314(5804):1461-1463
The inflammatory bowel diseases Crohn's disease and ulcerative colitis are common, chronic disorders that cause abdominal pain, diarrhea, and gastrointestinal bleeding. To identify genetic factors that might contribute to these disorders, we performed a genome-wide association study. We found a highly significant association between Crohn's disease and the IL23R gene on chromosome 1p31, which encodes a subunit of the receptor for the proinflammatory cytokine interleukin-23. An uncommon coding variant (rs11209026, c.1142G>A, p.Arg381Gln) confers strong protection against Crohn's disease, and additional noncoding IL23R variants are independently associated. Replication studies confirmed IL23R associations in independent cohorts of patients with Crohn's disease or ulcerative colitis. These results and previous studies on the proinflammatory role of IL-23 prioritize this signaling pathway as a therapeutic target in inflammatory bowel disease. 相似文献
1