排序方式: 共有18条查询结果,搜索用时 15 毫秒
1.
Changelian PS Flanagan ME Ball DJ Kent CR Magnuson KS Martin WH Rizzuti BJ Sawyer PS Perry BD Brissette WH McCurdy SP Kudlacz EM Conklyn MJ Elliott EA Koslov ER Fisher MB Strelevitz TJ Yoon K Whipple DA Sun J Munchhof MJ Doty JL Casavant JM Blumenkopf TA Hines M Brown MF Lillie BM Subramanyam C Shang-Poa C Milici AJ Beckius GE Moyer JD Su C Woodworth TG Gaweco AS Beals CR Littman BH Fisher DA Smith JF Zagouras P Magna HA Saltarelli MJ Johnson KS Nelms LF Des Etages SG Hayes LS Kawabata TT 《Science (New York, N.Y.)》2003,302(5646):875-878
Because of its requirement for signaling by multiple cytokines, Janus kinase 3 (JAK3) is an excellent target for clinical immunosuppression. We report the development of a specific, orally active inhibitor of JAK3, CP-690,550, that significantly prolonged survival in a murine model of heart transplantation and in cynomolgus monkeys receiving kidney transplants. CP-690,550 treatment was not associated with hypertension, hyperlipidemia, or lymphoproliferative disease. On the basis of these preclinical results, we believe JAK3 blockade by CP-690,550 has potential for therapeutically desirable immunosuppression in human organ transplantation and in other clinical settings. 相似文献
2.
Chakrapani V Angus JC Anderson AB Wolter SD Stoner BR Sumanasekera GU 《Science (New York, N.Y.)》2007,318(5855):1424-1430
Undoped, high-quality diamond is, under almost all circumstances, one of the best insulators known. However, diamond covered with chemically bound hydrogen shows a pronounced conductivity when exposed to air. This conductivity arises from positive-charge carriers (holes) and is confined to a narrow near-surface region. Although several explanations have been proposed, none has received wide acceptance, and the mechanism remains controversial. Here, we report the interactions of hydrogen-terminated, macroscopic diamonds and diamond powders with aqueous solutions of controlled pH and oxygen concentration. We show that electrons transfer between the diamond and an electrochemical reduction/oxidation couple involving oxygen. This charge transfer is responsible for the surface conductivity and also influences contact angles and zeta potentials. The effect is not confined to diamond and may play a previously unrecognized role in other disparate systems. 相似文献
3.
Venkataramanan Ragothaman Sreekumar Chirukandoth Anilkumar Rishipal Selvaraj P. Vidhya Nainar M. Mathagowder Iyue 《Tropical animal health and production》2010,42(5):1027-1029
Silage, which is anaerobically fermented green fodder, is valued throughout the world as a source of animal feed during lean
months. Several farms in India use carbohydrate sources like jaggery or molasses at 2% for preparation of silage, and this
increases cost of production. The present study was undertaken to assess the effect of jaggery on quality and intake of maize
silage, with an objective to find out whether additional carbohydrate source is essential in preparation of silage using green
maize. Three silage types, one without jaggery (A), the second with 1% jaggery (B), and the third with 2% jaggery (C) were
prepared in cylindrical bins under similar conditions. They were compared for colour, pH, lactic acid bacteria count, lactic
acid content, proximate composition and silage intake by sheep. Silage type C with 2% jaggery was significantly different
from the other two types with values of 3.98 and 805.66 g for pH and mean silage intake, respectively. Even though the values
of pH and dry matter intake for all three silage types were within normal levels, silage type C was significantly superior
in terms of fermentation and palatability. The method of preparation followed could be ideal for small holder farmers requiring
less quantity of silage. 相似文献
4.
5.
6.
7.
Akshaya Panigrahi Mani Sundaram Saranya Chakrapani Satishkumar Rajasekar Jagabattula Syama Dayal Gopal Chavali 《Aquaculture Research》2019,50(1):29-41
A 16‐week indoor culture trial was conducted to evaluate the effect of varying C:N ratio on growth performance, physico‐chemical parameters, microbial dynamics, feed utilization, and immunological parameters. The experiment comprised of five biofloc treatment groups (with varying C:N ratio 5:1, 10:1, 15:1, 20:1) and a control with three replicates each, having 100 nos/m3 as stocking density in 500 L tanks with constant aeration. The C:N ratios of the treatments were manipulated using molasses as an organic carbon source whereas there was no carbon source added in control. The water quality parameters monitored throughout the experiment were found to be within permissible limits in shrimp culture. At the end of the experiment, it was observed that there were significant differences between the treatment groups and the control regarding absolute growth, SGR, FCR, PER, and FER. Furthermore, a considerable difference in immunological parameters, namely, THC, phagocytosis, and PO activity (17.5 × 106 cells per ml, 43.5%, 0.112 Units min?1 mg min?1), was recorded among the treatments compared to that of the control groups (6.2 × 106 cells per ml, 31.5%, 0.051 Units min?1 mg min?1) respectively. Enhanced growth and survival with substantial disease resistance were recorded in C15 treatment. The results indicate that the CN15 ratio coupled with minimal water exchange is optimal for improved survival, growth, and immune activity. 相似文献
8.
The hypoglycemic effect of the aqueous extract of the seeds of Mucuna pruriens was investigated in normal, glucose load conditions and streptozotocin (STZ)-induced diabetic rats. In normal rats, the aqueous extract of the seeds of Mucuna pririens (100 and 200 mg/kg body weight) significantly (P<0.001) reduced the blood glucose levels after an oral glucose load from 127.5+/-3.2 to 75.6+/-4.8 mg% 2 h after oral administration of seed extract. It also significantly lowered the blood glucose in STZ diabetic rats from 240.5+/-7.2 to 90.6+/-5.6 mg% after 21 days of daily oral administration of the extract (P<0.001). Thus, this study shows that M. pruriens has an anti-hyperglycemic action and it could be a source of hypoglycemic compounds. 相似文献
9.
10.