Do boating and basking mix? The effect of basking disturbances by motorboats on the body temperature and energy budget of the northern map turtle

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Circulating autoantibodies to the 200,000-dalton protein of neurofilaments in the serum of healthy individuals

There is substantial evidence that human serum contains antibodies to many autoantigens. For example, all healthy people have autoantibodies (immunoglobulin M) to some undefined brain antigens. In this study immunoblots and immunohistochemical staining were used to detect antibodies to neural tissues in serum samples from 200 healthy people and 200 patients with various neurological diseases. Ninety-nine percent of the 400 subjects had serum immunoglobulin M and 95 percent had immunoglobulin G that bound to a 200-kilodalton protein in homogenates of neural tissues. In most cases there were no antibodies to anything else in the homogenates. The 200-kilodalton protein was the heaviest of the neurofilament triplet proteins. These observations do not support a role for antibodies to the 200-kilodalton protein of neurofilaments in the pathogenesis of neurological diseases.     

Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling

Microtubule (MT) stabilization is regulated by the small guanosine triphosphate (GTP)-binding protein Rho and its effector, mammalian homolog of Diaphanous (mDia), in migrating cells, but factors responsible for localized stabilization at the leading edge are unknown. We report that integrin-mediated activation of focal adhesion kinase (FAK) at the leading edge is required for MT stabilization by the Rho-mDia signaling pathway in mouse fibroblasts. MT stabilization also involved FAK-regulated localization of a lipid raft marker, ganglioside GM1, to the leading edge. The integrin-FAK signaling pathway may facilitate Rho-mDia signaling through GM1, or through a specialized membrane domain containing GM1, to stabilize MTs in the leading edge of migrating cells.     

The phototransformation of a bis-2,3-diazabutadienyldisulfide to an aphicidally active 2,3-dihydro-1,3,4-thiadiazole

The pro-insecticide bis-(1-(4-chlorophenyl)-4-(pyrid-3-yl)-2,3-diazabutadien-1-yl)disulfide, I is photochemically transformed to the aphicidally active 5-(4-chlorophenyl)-2-(pyrid-3-yl)-2,3-dihydro-1,3,4-thiadiazole IIa .