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1.
K Seeger 《Tier?rztliche Praxis》1988,16(2):109-112
Interrelations between host, bacterium and antibiotic compound in antibiotic therapy of bacterial infections are analysed. Some methods for the evaluation of antibacterial activity of antibiotics in vitro are described and their limits, in particular of the widely used MIC tests, are demonstrated. Data from trials comparing antibiotic applications once and twice a day as well as discussions in chemotherapy, concerning the applicability of in vitro results to therapy, are used to try to find practicable guidelines for the repetition of antibiotic therapy. 相似文献
2.
Seeger 《European Journal of Forest Research》1870,14(1):302-304
Ohne Zusammenfassung 相似文献
3.
Seeger 《European Journal of Forest Research》1869,13(1):328-332
Ohne Zusammenfassung 相似文献
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P. Seeger U. Thorsson B. Larsson K. Rnningen 《Aquaculture (Amsterdam, Netherlands)》1977,10(4):365-371
Salmon have been sampled repeatedly from seven troughs in order to evaluate the accuracy and precision of three different sampling methods. The average length of 2-summer-old salmon was determined to the nearest half centimetre after using a large scoop net which caught somewhat more than 200 fish per sweep. To avoid bias we had to use weighted means, with the weightings proportional to the square roots of the lengths. For 1-summer-old salmon we could use a smaller scoop net and unweighted means. 相似文献
7.
Marc-Oliver Aust Sören Thiele-Bruhn Juliane Seeger Frauke Godlinski Ralph Meissner Peter Leinweber 《Water, air, and soil pollution》2010,209(1-4):143-156
Sulfonamide antibiotics can enter agricultural soils by fertilisation with contaminated manure. While only rough estimations on the extent of such applications exist, this pathway results in trace level contamination of groundwater. Therefore, we studied the transport of three sulfonamides in leachates from field lysimeters after application of a sulfonamide-contaminated liquid manure. In a 3-year period, the sulfonamides were determined in 64% to 70% of all leachate samples at concentrations between 0.08 to 56.7 µg L?1. Furthermore, sulfonamides were determined in leachates up to 23 months after application, which indicated a medium- to long-term leaching risk. Extreme dry weather conditions resulted in highest dislocated amounts of sulfonamides in two of the three treatments. Furthermore, soil management such as tillage and cropping affected the time between application and breakthrough of sulfonamides and the intra-annual distribution of sulfonamide loads in leachates. Although the total sulfonamide leaching loads were low, the concentrations exceeded the limit value of the European Commission of 0.1 µg biocide L?1 in drinking water in more than 50% of all samples. Furthermore, the medium-term mean concentration of the sulfonamides ranged from 0.08 and 4.00 µg L?1, which was above the limit value of the European Commission in 91 out of 158 samples. Therefore, sulfonamides applied to soils in liquid manure under common agricultural practice may cause environmental and health risks which call for a setting up of more long-term studies on the fate of antibiotics. 相似文献
8.
Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage 总被引:89,自引:0,他引:89
G M Brodeur R C Seeger M Schwab H E Varmus J M Bishop 《Science (New York, N.Y.)》1984,224(4653):1121-1124
A domain of DNA designated N-myc is amplified 20- to 140-fold in human neuroblastoma cell lines but not in cell lines from other tumor types. N-myc has now been found to be amplified in neuroblastoma tissue from 24 of 63 untreated patients (38 percent). The extent of amplification appears to be bimodal, with amplification of 100- to 300-fold in 12 cases and 3- to 10-fold in 10 others. Amplification was found in 0 of 15 patients with stage 1 or 2 disease, whereas 24 of 48 cases (50 percent) with stage 3 or 4 had evidence of N-myc amplification. These data indicate that N-myc amplification is a common event in untreated human neuroblastomas. Furthermore, N-myc amplification is highly correlated with advanced stages of disease (P less than 0.001) and with the ability to grow in vitro as an established cell line, both of which are associated with a poor prognosis. 相似文献
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The Pyrenean and Pre‐Pyrenean mountain areas have been intensively used at least since roman times, but nowadays depopulation has lead to widespread land abandonment without a steering land‐management. Vegetation recovery is weak in most abandoned fields. Soil formation and characteristics are conditioned by this fact, and for this, soils show past degradation processes and are mostly predominant factors for continuing land degradation or restoration. Three study areas were set up along a climatic gradient with increasing summer water deficit in the sub‐humid zone between the Central Pyrenees and Pre‐Pyrenees. Soil survey combined with experiments for the determination of infiltration, runoff and erosion were applied for understanding the degradation history and the future development of the soils. All areas are dominated by Entisols, but also Inceptisols and Alfisols are found, and even soils with hydromorphic features. The soils show signs of heavy erosion. The parental material determines the nutrient supply and the general chemical properties. All sites show a weak water storing capacity, as a result of the removal of fine material by erosion and due to the depletion of soil organic matter. In addition, infiltration capacity and runoff generation are high within the studied areas, averaging between 27 and 37 per cent. The driest area studied shows an ongoing trend to degradation, with high erosion rates combined with a high degradations status of the soil. The other areas are characterised by a patchy pattern of soil degradation and regradation processes. Copyright © 2008 John Wiley & Sons, Ltd. 相似文献