Dactylospongia elegans—A Promising Drug Source: Metabolites,Bioactivities, Biosynthesis,Synthesis, and Structural-Activity Relationship

Marine environment has been identified as a huge reservoir of novel biometabolites that are beneficial for medical treatments, as well as improving human health and well-being. Sponges have been highlighted as one of the most interesting phyla as new metabolites producers. Dactylospongia elegans Thiele (Thorectidae) is a wealth pool of various classes of sesquiterpenes, including hydroquinones, quinones, and tetronic acid derivatives. These metabolites possessed a wide array of potent bioactivities such as antitumor, cytotoxicity, antibacterial, and anti-inflammatory. In the current work, the reported metabolites from D. elegans have been reviewed, including their bioactivities, biosynthesis, and synthesis, as well as the structural-activity relationship studies. Reviewing the reported studies revealed that these metabolites could contribute to new drug discovery, however, further mechanistic and in vivo studies of these metabolites are needed.     

Soil organic matter amendments in date palm groves of the Middle Eastern and North African region: a mini-review

Countries in the Middle Eastern and North African(MENA) region are among the most water-scarce regions in the world, and their dryland soils are usually poor in organic carbon content(<0.5%). In this study, we summarize examples of how people in the few oases of the MENA region overcome environmental challenges by sustainably managing economically important date production. On the basis of the limited studies found in the existing literature, this mini-review focuses on the role of traditional soil organic matter amendments beneath the soil surface as a key tool in land restoration. We conclude that soil organic matter amendments can be very successful in restoring soil water and preventing the soil from salinization.     

Soil Organic Matter Composition in Coastal and Continental Date Palm Systems: Insights from Tunisian Oases

In Tunisia, the coastal Chenini oasis is characterized by a lush vegetation cover, whereas more inland continental oases (e.g., the Guettaya oasis) have a very scarce vegetation cover. For sustaining date palm production in these areas, organic fertilizers are applied, either spread on the soil surface (in Chenini) or buried under a sand layer (in Guettaya). We examined at a molecular level how these management techniques affect soil organic matter composition in oasis systems. A dominance of fresh plant input for Guettaya was indicated by solid-state ¹³C nuclear magnetic resonance spectroscopy signals, which was most pronounced in the uppermost soil close to palms. Evidence for more degraded organic matter was found in deeper soil near the palms, as well as in the soil distant from the palms. Amino sugar contents were low in the uppermost Guettaya soil near the palms. The overall microbial amino sugar residue contents were similar in range as those found in other dryland environments. With increasing distance from trees, the amino sugar contents declined in Guettaya, where the palms grow on bare soil, but this was not the case for Chenini, which has multi-layer vegetation cover under palms. In agreement with the results from previous dryland studies, the soil microbial community in both oasis systems was dominated by fungi in topsoil, and a shift toward bacteria-derived residues in subsurface soil. This might be due to higher variability of temperature and moisture in topsoil and/or lower degradability of fungal remains; however, further research is required to confirm this hypothesis.     

Insulin‐Like Growth Factor‐1 Regulates the Expression of Luteinizing Hormone Receptor and Steroid Production in Bovine Granulosa Cells

Luteinizing hormone LH plays important roles in follicular maturation and ovulation. The effects of LH are mediated by LH receptor (LHR) in the ovary. However, the factors that regulate the expression of LHR in bovine granulosa cells (GCs) are not well known. Insulin‐like growth factor‐1 (IGF‐1) is known to play a key role in the acquisition and maintenance of functional dominance. To better understand the roles of LHR expression and IGF‐1, we conducted three experiments to determine (i) mRNA expression of LHR in the GCs of developing follicles, (ii) the effects of IGF‐1 on LHR mRNA expression in cultured GCs and (iii) the effects of IGF‐1 on estradiol (E2), progesterone (P4) and androstenedione (A4) production by non‐luteinized GCs. In experiment 1, small follicles (<6 mm Ø) expressed lower levels of LHR than mid‐sized follicles (6–8 mm Ø) and large follicles (≥9 mm Ø) expressed the highest levels of LHR mRNA (p < 0.05). In experiment 2, IGF‐1 (1 and 100 ng/ml) increased (p < 0.05) the expression of LHR mRNA in GCs from small and large follicles. In experiment 3, IGF‐1 (0.1–100 ng/ml) increased A4 and E2 in GCs from both small and large follicles but increased P4 only in large follicles. IGF‐1 in combination with LH (0.1 and 1 ng/ml) increased P4 and A4 in large follicles, and increased E2 and A4 in GCs of small follicles. These findings strongly support the concept that IGF‐1 upregulates LHR mRNA expression as well as A4 and E2 production in GCs and that IGF‐1 is required for determining which follicle becomes dominant and acquires ovulatory capacity.