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Auffray C Fogg D Garfa M Elain G Join-Lambert O Kayal S Sarnacki S Cumano A Lauvau G Geissmann F 《Science (New York, N.Y.)》2007,317(5838):666-670
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX(3)CR1 and was required for rapid tissue invasion at the site of an infection by this "resident" monocyte population, which initiated an early immune response and differentiated into macrophages. 相似文献
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Belarbi M Bendimerad S Sour S Soualem Z Baghdad C Hmimed S Chemat F Visioli F 《Journal of agricultural and food chemistry》2011,59(16):8667-8669
The olive tree had been domesticated during the early Neolithic in the Near East, and more than 1000 different cultivars have been identified to date. However, examples of wild olive trees (Olea europaea oleaster) can still be found in the Mediterranean basin. Evidence of oleaster use for oil production can be found in historical and sacred texts, such as the Odyssey, the Holey Koran, and the Holey Bible. While the nutritional and healthful properties of olive oil are actively being explored, there are no data on the human actions of oleaster oil. Therefore, we investigated the effect of prolonged, i.e., 1 month, consumption of oleaster oil on the lipid profile of a 40 healthy Algerian subjects (aged 27.9 ± 3.85 years), as compared to nonconsumers from the same area. Plasma urea, creatinine, and uric acid concentrations and glycemia did not significantly differ, at the end of the study, between controls and oleaster-oil-supplemented subjects. Conversely, we recorded significant decreases of plasma triglyceride concentration (-24.8%; p < 0.05), total cholesterol (-12.13%; p < 0.05), and low-density lipoprotein-cholesterol (LDL-C) (-24.39%; p < 0.05) in oleaster-oil-treated subjects. Concomitantly, high-density lipoprotein-cholesterol (HDL-C) concentrations were significantly increased (17.94%; p < 0.05) by oleaster oil administration. In conclusion, we show that oil obtained from feral olive trees, i.e., oleasters, improves the plasma lipid profile of healthy volunteers. 相似文献
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Félix P. Hartmann Cyrille B. K. Rathgeber Meriem Fournier Bruno Moulia 《Annals of Forest Science》2017,74(1):14
Key message
The emergence of the characteristic tree-ring pattern during xylogenesis is commonly thought to be controlled by a gradient of morphogen (auxin, TDIF peptide...). We show that this hypothesis accounts for several developmental aspects of wood formation, but not for the final anatomical structure.Context
Wood formation is a dynamic cellular process displaying three generic features: (i) meristematic cell proliferation is restricted to the small cambial zone, preventing exponential xylem radial growth along the growing season; (ii) developmental processes result in a stable zonation of the developing xylem; (iii) the resulting mature wood cells form the typical tree-ring structure made of early and late wood with a gradient of cell sizes, an important trait for wood functioning in trees and for lumber quality. The mechanisms producing these spatial-temporal patterns remain largely unknown. According to the often-cited morphogenetic-gradient hypothesis, a graded concentration profile of a signalling molecule (e.g. auxin, TDIF) controls xylogenesis by providing positional information to differentiating cells.Aims
We assessed the predictions of the morphogenetic-gradient theory.Methods
We developed a computational model of wood formation implementing hypotheses on how a morphogen flows through the developing xylem and controls cell division and growth and we tested it against data produced by studies monitoring wood formation in conifers.Results
We demonstrated that a morphogenetic gradient could indeed control xylem radial growth and wood-forming tissue zonation. However, it failed to explain the pattern of final cell sizes observed in tree-rings. We discussed the features that candidate additional regulatory mechanisms should meet.5.
Estelle Noyer Barbara Lachenbruch Jana Dlouhá Catherine Collet Julien Ruelle François Ningre Meriem Fournier 《Annals of Forest Science》2017,74(2):46
Key message
The position of trees in the canopy impacts xylem structure and its inter-annual variation. After canopy release, the increase in the hydraulic conductivity of growth rings was driven by an increase in radial growth in large trees, and by both an increase in radial growth and changes in xylem structure in saplings.Context
Forest canopies are frequently subjected to disturbances that allow understory trees to access the upper canopy. The effect of canopy release on xylem anatomy has been assessed in juvenile trees and saplings, while the potential acclimation of larger trees remains poorly documented.Aims
We estimated the potential hydraulic conductivity of growth rings in large understory trees compared to overstory trees, and evaluated the responses to canopy release in large trees and in saplings.Methods
We recorded radial growth, wood density, and vessel structure in beech trees according to their position within the canopy and their size. Xylem traits were followed during 6 years after canopy release for large trees, and during 2 years for saplings. Vessel diameter and frequency as well as ring area were used to compute the potential annual ring hydraulic conductivity.Results
Large understory trees displayed lower radial growth increments and lower potential annual ring hydraulic conductivity than overstory trees. After canopy release, potential annual ring hydraulic conductivity increased in large trees, due exclusively to increased radial growth without any change in specific hydraulic conductivity. It increased in saplings due to both increased radial growth and increased specific conductivity.Conclusion
Tree size impacted xylem structure and resulted in plasticity of the potential hydraulic conductivity of the annual tree ring following canopy release.6.
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Viviana Torres Meriem Hamdi Veronica Maillo Rodrigo Urrego Jose Julian Echeverri Albeiro Lpez‐Herrera Alfonso Gutirrez‐Adn Dimitrios Rizos Maria Jesús Snchez‐Calabuig 《Reproduction in domestic animals》2019,54(1):55-62
Ascorbic acid (AC) used as antioxidant in embryo culture is very sensitive and degrades unavoidably in aqueous solution. Methyl‐β‐cyclodextrin (CD) improved the stability of AC in solution to elevated temperature, light, humidity and oxidation. The aim of this study was to evaluate the effect of the complex AC‐CD during in vitro maturation (IVM) or in vitro culture (IVC) on oocyte developmental competence and subsequent embryo development and quality. AC‐CD (100 µM) was added to IVM media, and maturation level and embryo development were examined. Matured oocytes, their cumulus cells and produced blastocysts were snap‐frozen for gene expression analysis by RT‐qPCR. Besides, in vitro‐produced zygotes were cultured with 100 µM of AC‐CD and blastocysts were as well snap‐frozen for gene expression analysis. A group without AC‐CD (control?) and other with CD (control+) were included. No differences were found on maturation, cleavage or blastocyst rates. However, in matured oocytes, AC‐CD downregulated BAX, GPX1 and BMP15. In cumulus cells, AC‐CD downregulated BAX/BCL2 and GSTA4 while upregulated BCL2 and CYP51A1. The expression of SL2A1, FADS1, PNPLA and MTORC1 was downregulated in blastocysts derived from oocytes matured with AC‐CD, while in blastocysts derived from zygote cultured with AC‐CD, CYP51A1 and IGF2R were downregulated and PNPLA2 was upregulated. In conclusion, AC‐CD in both IVM and IVC media may reduce accumulated fat by increasing lipolysis and suppressing lipogenesis in blastocysts derived from both oocytes and zygotes cultured with AC‐CD, suggesting that CD improves the quality of embryos and bioavailability of AC during IVM and IVC. 相似文献
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