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排序方式: 共有66条查询结果,搜索用时 15 毫秒
1.
E. Marx C. H. Metzger B. A. Brown Eugene W. Whitman H. R. Talmage Frank W. Hussey H. A. Reiley Marx Koehnke J. C. Campbell E. V. Hardenburg Karl H. Fernow Earl B. Tussing E. R. Jackman C. A. Henderson O. D. Burke K. W. Lauer John Noonan H. L. Bailey Chas D. Gaines W. N. Keenan R. E. Goodin 《American Journal of Potato Research》1943,20(8):224-236
2.
Snyder Marcía N. Schumaker Nathan H. Ebersole Joseph L. Dunham Jason B. Comeleo Randy L. Keefer Matthew L. Leinenbach Peter Brookes Allen Cope Ben Wu Jennifer Palmer John Keenan Druscilla 《Landscape Ecology》2019,34(5):1197-1197
Landscape Ecology - In the original publication of the article, the third author name has been misspelt. The correct name is given in this Correction. The original version of this article was revised. 相似文献
3.
Observations on growth, sexual maturity and spawning performance of pond-reared Penaeus merguiensis 总被引:2,自引:0,他引:2
This 12‐month preliminary study investigated the development of sexual characters, primary sexual maturity, ovarian maturity and spawning performance of pond‐reared Penaeus merguiensis in relation to culture conditions in south‐east Queensland, Australia. Post‐larvae of P. merguiensis were produced and cultured in two 60‐m3 tanks during the first 14 weeks. Before winter, they were harvested and stocked in three different overwintering facilities: a 200‐m2 covered pond, two 60‐m3 outdoor tanks and a 15‐m3 indoor, recirculated tank at a stocking density of 10 individuals m?2. The development of sexual characters was found to be similar to that reported previously in wild P. merguiensis. Males matured at younger ages and smaller sizes than females. Overall, the average size at primary sexual maturity of pond‐reared P. merguiensis was 23.1 mm carapace length for males (possessed spermatophores) and 29.3 mm for females (being impregnated). Water temperature and the availability of natural food strongly influenced prawn growth, maturity rate and their subsequent spawning performance. Growth, maturity rate and spawning performance of prawns in the covered pond were significantly higher than in the other overwintering facilities. Prawns started mating at 6–7 months, reached full ovarian maturation and spawned as early as about 8 (peaked at 9–11) months from hatching, producing high fecundity and viable larvae. There was a strong relationship (P < 0.001) between prawn size and fecundity. The results of this study suggest a potential for using pond‐reared broodstock P. merguiensis for hatchery production and for domestication or selective breeding programmes. 相似文献
4.
Charlotte M. Keenan Julia F. Baker Alys E. Bradley Dawn G. Goodman Takanori Harada Ronald Herbert Wolfgang Kaufmann Rupert Kellner Beth Mahler Emily Meseck Thomas Nolte Susanne Rittinghausen John Vahle Katsuhiko Yoshizawa 《Journal of toxicologic pathology》2015,28(1):51-53
The INHAND Proposal (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) has been operational since 2005. A Global Editorial Steering Committee (GESC) manages the overall objectives of the project and the development of harmonized terminology for each organ system is the responsibility of the Organ Working Groups (OWG), drawing upon experts from North America, Europe and Japan.Great progress has been made with 9 systems published to date – Respiratory, Hepatobiliary, Urinary, Central/Peripheral Nervous Systems, Male Reproductive and Mammary, Zymbals, Clitoral and Preputial Glands in Toxicologic Pathology and the Integument and Soft Tissue and Female Reproductive System in the Journal of Toxicologic Pathology as supplements and on a web site – www.goreni.org. INHAND nomenclature guides offer diagnostic criteria and guidelines for recording lesions observed in rodent toxicity and carcinogenicity studies. The guides provide representative photo-micrographs of morphologic changes, information regarding pathogenesis, and key references. During 2012, INHAND GESC representatives attended meetings with representatives of the FDA Center for Drug Evaluation and Research (CDER), Clinical Data Interchange Standards Consortium (CDISC), and the National Cancer Institute (NCI) Enterprise Vocabulary Services (EVS) to begin incorporation of INHAND terminology as preferred terminology for SEND (Standard for Exchange of Nonclinical Data) submissions to the FDA. The interest in utilizing the INHAND nomenclature, based on input from industry and government toxicologists as well as information technology specialists, suggests that there will be wide acceptance of this nomenclature. The purpose of this publication is to provide an update on the progress of INHAND. 相似文献
5.
The sialyl transferase of disialoganglioside formation is depressed in mammary tumors induced in the rat by 7,12-dimethylbenz[a]anthracene. Specific activities of other glycosyltransferases of the pathway ceramide to monosialo-ganglioside are unchanged or elevated so that the ganglioside GM(1) accumulates and higher gangliosides are depressed. These findings with a solid tumor are critical to an involvement of gangliosides in the cell-surface changes of tumorigenesis. 相似文献
6.
Rivera VM Wang X Wardwell S Courage NL Volchuk A Keenan T Holt DA Gilman M Orci L Cerasoli F Rothman JE Clackson T 《Science (New York, N.Y.)》2000,287(5454):826-830
A system for direct pharmacologic control of protein secretion was developed to allow rapid and pulsatile delivery of therapeutic proteins. A protein was engineered so that it accumulated as aggregates in the endoplasmic reticulum. Secretion was then stimulated by a synthetic small-molecule drug that induces protein disaggregation. Rapid and transient secretion of growth hormone and insulin was achieved in vitro and in vivo. A regulated pulse of insulin secretion resulted in a transient correction of serum glucose concentrations in a mouse model of hyperglycemia. This approach may make gene therapy a viable method for delivery of polypeptides that require rapid and regulated delivery. 相似文献
7.
Long-term synaptic potentiation 总被引:16,自引:0,他引:16
Long-term synaptic potentiation (LTP) is a leading candidate for a synaptic mechanism of rapid learning in mammals. LTP is a persistent increase in synaptic efficacy that can be quickly induced. The biophysical process that controls one type of LTP is formally similar to a synaptic memory mechanism postulated decades ago by the psychologist Donald Hebb. A key aspect of the modification process involves the N-methyl-D-aspartate (NMDA) receptor-ionophore complex. This ionophore allows calcium influx only if the endogenous ligand glutamate binds to the NMDA receptor and if the voltage across the associated channel is also sufficiently depolarized to relieve a magnesium block. According to one popular hypothesis, the resulting increase in the intracellular calcium concentration activates protein kinases that enhance the postsynaptic conductance. Further biophysical and molecular understanding of the modification process should facilitate detailed explorations of the mnemonic functions of LTP. 相似文献
8.
L N Binn R H Marchwicki K P Keenan A J Strano W F Engler 《American journal of veterinary research》1977,38(7):927-929
Two similar cytopathic agents were recovered from the throat and rectal swab specimens of an immature dog with upper respiratory tract disease. The reference isolate, 14-72R, was shown to be a member of the reovirus group by its physicochemical properties, cytopathic effects in cell cultures, and appearance when examined in the electron microscope. Both isolates hemagglutinated human type O erythrocytes and antigenically were closely related to reovirus type 2. The affected pup had an increase in antibody titer to reovirus types 2 and 3. The latter findings provide evidence for possible heterotypic antibody responses in dogs to reovirus infection. 相似文献
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