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排序方式: 共有203条查询结果,搜索用时 125 毫秒
1.
R Bergman 《Research in veterinary science》1978,25(2):193-199
Calves less than four weeks old could not be infected with a neuraminidase-weak strain of parainfluenza-3 virus (Pi3) but were successfully infected with either of two neuraminidase-strong strains. The criteria for infection were virus excretion, cell-mediated and antibody-mediated immune responses. In the lymphocyte stimulation test, calves infected with the neuraminidase-strong Pi3 strain Tüb-E6 responded more strongly to antigen prepared from this strain than to antigen from the heterologous Pi3 strain Um-23. The non-immunoglobulin haemagglutination inhibition activity of the liquid phase of nasal secretions of newborn calves decreased after treatment with Vibrio cholerae neuraminidase. For virus-bound neuraminidase the liquid phase from newborn calves was a richer substrate than the liquid phase from older animals. 相似文献
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Meijer L Hafkamp AM Bosman WE Havinga R Bergman A Sauer PJ Verkade HJ 《Journal of agricultural and food chemistry》2006,54(17):6440-6444
Polybrominated diphenyl ethers are lipophilic persistent organic pollutants (POPs), which accumulate in the environment, leading to human exposure. The compounds exert a negative impact on human health. Strategies to prevent or diminish their accumulation in humans are required. We investigated in rats whether the disposal rate of 14C-labeled tetrabromodiphenyl ether (BDE-47) could be enhanced by increasing fecal fat excretion through dietary treatment with nonabsorbable fat (sucrose polyester, SPE). As compared to control rats, SPE treatment increased fecal excretion rates of fat (+188%, p < 0.05) and 14C-BDE-47 (+291%, p < 0.05). On the basis of biliary secretion and fecal excretion rates of 14C-BDE-47, SPE effectively inhibited the enterohepatic circulation of 14C-BDE-47. In conclusion, dietary supplementation of nonabsorbable fat can enhance excretion of hydrophobic POPs by interruption of their enterohepatic circulation. Our data indicate that this strategy could decrease concentrations of hydrophobic POPs in the human body and thereby their impact on human health. 相似文献
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Johansson L Rytkonen A Bergman P Albiger B Källström H Hökfelt T Agerberth B Cattaneo R Jonsson AB 《Science (New York, N.Y.)》2003,301(5631):373-375
The human-specific bacterial pathogen Neisseria meningitidis is a major cause of sepsis and/or meningitis. The pili of N. meningitidis interact with CD46, a human cell-surface protein involved in regulation of complement activation. Transgenic mice expressing human CD46 were susceptible to meningococcal disease, because bacteria crossed the blood-brain barrier in these mice. Development of disease was more efficient with piliated bacteria after intranasal, but not intraperitoneal, challenge of CD46 transgenic mice, suggesting that human CD46 facilitates pilus-dependent interactions at the epithelial mucosa. Hence, the human CD46 transgenic mice model is a potentially useful tool for studying pathogenesis and for vaccine development against meningococcal disease. 相似文献
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Bergman PJ 《Clinical Techniques in Small Animal Practice》2003,18(2):88-91
The diagnosis, staging, and treatment of tumors in veterinary as well as human oncology have traditionally incorporated elements of anatomic extent of neoplasia through various clinical and pathologic methods. These clinicopathological methods have been the basis for the development of the tumor, node, and metastasis and grading systems, which have translated into clinically significant advances over the last 20 to 30 years. Unfortunately, there continues to be significant limitations to this system when prognostication and therapeutic decisions need to be made specific to a patient. For example, completely resected and cleanly staged phenotypically identical grade II mast cell tumors in dogs can have opposing clinical outcomes. In addition, dogs or cats with identical stage and grade lymphoma can have significantly divergent responses to the same multi-agent chemotherapy protocol. Numerous nonanatomic neoplastic molecular prognostic factors have been recently identified and have the potential to improve on the presently available tumor, node, and metastasis- and grading-based systems. To date in human oncology, single nonanatomic factors have only occasionally translated into efficient and independent prognostic factors, which speaks to the heterogeneity of cancer. Therefore, the use of panels of factors have been encouraged that will allow for the development of a molecular prognostic index, which can then be used in concert with presently available systems. This review will summarize how to best utilize presently available tumor, node, and metastasis- and grading-based systems, and incorporate newly available molecular prognostic factors. 相似文献
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Bergman L Hart BL Bain M Cliff K 《Journal of the American Veterinary Medical Association》2002,221(9):1282-1286
OBJECTIVE: To obtain information regarding diagnostic and treatment approaches of veterinarians and attitudes and beliefs of clients about a common clinical problem, urine marking in cats. DESIGN: Cohort study. STUDY POPULATION: 70 veterinarians providing care for urine-marking cats and 500 owners of urine-marking cats. PROCEDURE: Veterinarians were interviewed via telephone regarding criteria for diagnosis of urine marking and recommended treatments. Cat owners who responded to recruitment efforts for a clinical trial for urine-marking cats were interviewed via telephone regarding whether and from what sources they sought help to resolve the marking problem. RESULTS: Almost a third of veterinarians did not seem to correctly distinguish between urine marking (spraying) and inappropriate urination. Those that did make this diagnostic distinction reported recommending environmental management and prescribing medication significantly more often that those that did not make this distinction. Seventy-four percent of cat owners sought help from their veterinarians for urine marking; other common sources of information were the Internet and friends. Among those who did not consult a veterinarian, the most frequently cited reason was that they did not think their veterinarian could help. Among cat owners who consulted their veterinarians, 8% reported receiving advice on environmental hygiene and 4% on environmental management (limiting intercat interactions), although veterinarians who correctly diagnosed urine marking reported giving such advice 100 and 83% of the time, respectively. CONCLUSIONS AND CLINICAL RELEVANCE: Results may serve as a model for obtaining information critical to developing veterinary continuing education and public outreach programs for animal owners for various diseases. 相似文献
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Wiemer P Bergman HJ van der Veen H Pruissen L 《Tijdschrift voor diergeneeskunde》2002,127(22):682-686
In the period from January 1995 until December 2000, 272 horses underwent a laparotomy for gastrointestinal disorders. The results of these surgeries were evaluated. From these 272 patients 176 (= 65%) were discharged in good health from the hospital. When the patients that were euthanized immediately after the start of the surgery, because of a fatal deterioration, were not taken into account, the short time survival rate was 77%. Strangulated small and large intestinal obstructions (48%) had a lower short time survival rate than non-strangulated obstructions (87%). Fatal postoperative complications occurred in 18% of the patients in which the surgery was completed. Postoperative shock was the most common cause. Non-fatal complications were found in 16% of the patients which survived surgery. The major non-fatal complications were incisional hernia and thrombophlebitis of the jugular vein. From the patients that survived the surgery 81% returned to their former level of performance. Early referral may decrease the percentage of fatal complications and improve the prognoses of surgery. 相似文献
10.
Multiple, dermal and subcutaneous nodules developed in a young female Manchester Terrier dog that had a chronic history of superficial dermatophytosis. Skin biopsy specimens of the nodules revealed granulomatous inflammation in the deep dermis and subcutis with branching fungal organisms. Cultures of multiple biopsy specimens from the nodules all yielded Trichophyton mentagrophytes. The lesions in this dog were similar to granulomatous dermatophytosis, a skin disease that has been reported in Persian cats and one Yorkshire Terrier dog. 相似文献