Research Progress on Biological Mechanism of Epoxyeicosatrienoic Acids

Epoxyeicosatrienoic acids (EETs) are synthesized from arachidonic acid by cytochrome P450 epoxygenases.They modulate ion transport and gene expression,producing vasorelaxation as well as antiinflammatory and cell proliferation effects.Many of the functional effects of EETs occur through activation of signal transduction pathways and modulation of gene expression,events probably initiated by binding to a putative cell surface EETs receptor.However,EETs are rapidly taken up by cells and are incorporated into and released from phospholipids,it suggests that some functional effects may occur through a direct interaction between the EETs and an intracellular effector system.EETs synthesis,metabolism,mechanism of action are reviewed in this paper.     

胎盘提取物的制备与免疫调节功能及应用研究进展

主要介绍了胎盘提取物的制备方法、免疫调节功能以及在生产生活中的应用。总结出, 胎盘提取物有着免疫调节、抗氧化、抗肿瘤和营养作用;其制备方法主要有超滤法、酶解法和微生物发酵法, 各自具有优势和不足, 选择胎盘提取物制备方法时可以根据自有的条件和要求及前人的经验综合判断;在皮肤护理方面, 胎盘提取物可以作为抗氧化成分添加到护肤品中以起到延缓皮肤衰老的作用;在疫病治疗方面, 能改善肝炎患者的临床症状和肝功能, 对胰腺癌细胞的增殖有负调控作用, 对于超敏反应也有一定的治疗效果, 在神经再生方向效果显著。胎盘提取物在保健品和护肤品研发、疾病治疗方面应用前景广阔。     

环氧二十碳三烯酸生物学作用机制的研究进展

花生四烯酸经过细胞色素P450 (cytochrome P450,CYP)表氧化酶途径生成环氧二十碳三烯酸(epoxyeicosatrienoic acids,EETs)。EETs可以通过调节离子通道和基因表达,从而发挥促进血管舒张、抗炎和细胞增殖等作用。EETs也可通过激活信号转导途径和调节基因表达或与细胞膜受体结合发挥多种生物学功能。EETs也可快速与细胞膜磷脂结合后以共吸收的方式被细胞摄取。文章主要从EETs的来源、去路、作用机制等方面进行讨论。