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1.
Sridhar Veluvolu Jennifer L. Willcox Katherine A. Skorupski Sami Al-Nadaf Robert Rebhun Luke Wittenburg 《Veterinary and comparative oncology》2023,21(1):20-27
Cyclophosphamide (CP) is an alkylating agent commonly included in multi-drug treatment protocols for canine cancer. As a prodrug, CP requires hepatic metabolism for activation to the intermediate compound 4-hydroxycyclophosphamide (4-OHCP) which then spontaneously forms alkylating phosphoramide mustard. CP is frequently administered in a fractionated manner, with the total dose given over multiple days. CP is reported to cause auto-induction of metabolism in humans, with faster CP clearance and relatively increased 4-OHCP formation following fractionated versus bolus dosing, however canine pharmacokinetic studies of CP dose fractionation are lacking. The study objective was to evaluate the pharmacokinetics of fractionated oral CP dosing at a dose of 200–250 mg/m2 over 3 to 4 days in a prospectively identified population of cancer-bearing dogs. Plasma concentrations of CP and 4-OHCP were measured by ultra-high performance liquid chromatography tandem-mass spectrometry in eight dogs following the first and last doses to assess for auto-induction of CP metabolism. No significant difference in the rate of CP elimination between first and last doses were detected (0.73 ± 0.46 vs. 1.22 ± 0.5 h−1; p = .125). Additionally, no significant difference in dose-normalized 4-OHCP exposure was identified between first and last doses (5.9 ± 2.1 vs. 7.9 ± 6.4 h × ng/ml; p = .936). These results suggest that fractionated dosing may not increase exposure to the active metabolite of CP in dogs as it does in humans. As such, standard bolus dosing and fractionated dosing may be equivalent in terms of bio-activation of CP in dogs administered a dose of 200–250 mg/m2. 相似文献
2.
Zaluzanin D, a sesquiterpene lactone has been isolated from the aerial parts of Vernonia arborea as a major constituent (0.04%). Antifungal activity of zaluzanin D has been studied against six plant-pathogenic fungi. 相似文献
3.
Ikem A. Osibanjo O. Sridhar M. K. C. Sobande A. 《Water, air, and soil pollution》2002,140(1-4):307-333
Two industrial and highly populated cities namely Ibadan and Lagos, both located in Southwestern Nigeria have urban migrationproblems and resource limitations. As a result, the development of residential areas near waste sites and the indiscriminate dumping of municipal waste are common in both cities. Orita-Aperin and Oworonsoki neighborhoods in Ibadan and Lagos,respectively, both located near a waste site were studied. The two areas relied on the wells as sources of drinking water hence poor drinking water quality may have health consequences. A totalof 51 ground-water samples (30 wells in Ibadan and 21 wells in Lagos) were monitored seasonally for two years in Ibadan and a year in Lagos. Results from this study revealed that some of theground-water quality constituents determined exceeded the World Health Organization (WHO) standards for drinking water irrespective of source of pollution. Some of the ground-water samples were poor in quality in terms of pH, conductivity, totaldissolved solids, chloride, nitrate, ammonia, COD, Al, Cd, Cr, Fe, Pb, Ni and total coliforms recorded. Thus, ground-water fromsome of these private wells requires further purification to ensure its fitness for human consumption.F-test, one-way parametric analysis of variance (ANOVA), Mann-Whitney `T' test and Kruskal-Wallis H-test applied to upgradient and downgradient concentrations suggest impact ofthe waste sites on ground-water quality. The Mann-Whitney testonly suggests that the downgradient values of Fe (Ibadan: dryseason (1), sulfate (Ibadan: rainy season (2) and pH (Lagos: dry season (2) were significant at 5% level of significance. For Ibadan wells, the Kruskal-Wallis test showed that variances ofspecific conductivity, dissolved solids, and chloride for Ibadanupgradient and downgradient values were unequal. Also variances of specific conductivity and dissolved solids for upgradient anddowngradient values in Lagos were unequal at 5% level of significance. Three downgradient wells in Lagos and four downgradient wells in Ibadan had significant impact due to leachate migration into drinking wells. 相似文献
4.
Five horses with long incomplete longitudinal fractures of the third metacarpal bone and three horses with similar fractures of the third metatarsal bone were examined. In three of the metacarpal fractures a long incomplete fissure extended proximomedially, in association with the more common lateral condylar fracture of the third metacarpal bone, and in the other two cases the fracture originated from the medial aspect of the distal articular surface. In the three horses with fractures of the third metatarsal bone the fractures had a consistent spiral configuration. 相似文献
5.
We used standard isolation protocols to explore the endophytic fungal communities in three tissue types of two dominant orchids (Bulbophyllum neilgherrense and Vanda testacea) of the Kaiga forest ofthe Western Ghats. We surface sterilized and assessed 90 segments ofeach orchid for the occurrence and diversity of endophytic fungal taxa.The 118 fungal isolates were obtained from root, bulb and leaves of B.neilgherrense, consisting of 17 anamorphic taxa (range, 10 15 taxa) with 1.3 fungal taxa per segment (range, 1.2 1.4 taxa). Four taxa (Aspergillus flavus, A. niger, Penicillium sp. and morpho sp. 1) belonged to the coregroup (11.1% 32.2%). The relative abundance of A. flavus and morpho sp.1 was more than 10%. A total of 130 fungal isolates from roots, stems and leaves of V. testacea yielded 20 anamorphic taxa (range, 11 15 taxa)with 1.4 fungal taxa per segment (range, 1.4 1.5 taxa). Aspergillus flavus,A. niger, A. ochraceus, Gliocladium viride, Penicillium sp. and morphosp. 1 belonged to the core group. Relative abundance exceeded 10% for A. flavus, A. niger, and morpho sp. 1. The Simpson and Shannon diversity indices were higher in leaf than root or bulb/stem of both orchids.Jaccard’s similarity coefficient was higher between root and leaf in both orchids (56.3% 60%) than between other pairs. Our study revealed thatthe endophytic fungal assemblage and diversity of B. neilgherrense and V.testacea of Kaiga forest of the Western Ghats were relatively similar between orchids and their tissues. 相似文献
6.
Sridhar BHAVANI David P. HODSON Julio HUERTA-ESPINO Mandeep S. RANDHAWA Ravi P. SINGH 《农业科学与工程前沿(英文版)》2019,6(3):210
Races belonging to the Ug99 (TTKSK) lineage of the wheat stem rust fungus, carrying complex virulence combinations, and their migration to countries in Africa, Middle East and Asia continue to pose a significant threat to global wheat production. The rapid spread of additional races, e.g., TKTTF or the Digalu lineage, in several countries causing localized epidemics reminds us of the vulnerability of wheat germplasm to stem rust disease, a formidable foe referenced as early as biblical times. A global rust monitoring system reflecting increased surveillance efforts has identified 13 races within the Ug99 lineage in 13 countries and unrelated lineages are emerging, spreading and posing serious threats to wheat production. Race TKTTF has caused localized epidemics in Ethiopia and its variants have been recently implicated in stem rust outbreaks in Europe. Concerted research efforts have resulted in the identification of several new resistance genes and gene combinations for use in breeding. Combining multiple adult plant resistance (APR) genes in high-yielding backgrounds and discovery of new quantitative trait loci conferring stem rust resistance has progressed in the recent years, enhancing the durability of resistance. Effective gene stewardship and new generation breeding materials and cultivars that combine multiple race-specific or minor to intermediate effect APR genes, complemented by active surveillance and monitoring, have helped to limit major epidemics and increase grain yield potential in key target environments. 相似文献
7.
Kisseberth WC Murahari S London CA Kulp SK Chen CS 《American journal of veterinary research》2008,69(7):938-945
OBJECTIVE: To determine whether exposure of canine cancer cells to histone deacetylase (HDAC) inhibitors S(+)-N-hydroxy-4-(3-methyl-2-phenyl-butyrylamino)benzamide (OSU-HDAC42) or suberoylanilide hydroxamic acid (SAHA) results in increased histone acetylation and decreased cell viability and whether any changes in viability involve induction of apoptosis or alterations in progression of the cell cycle. Sample POPULATION: 9 canine cancer cell lines. PROCEDURES: Cells from 9 canine cancer cell lines were treated with dimethyl sulfoxide vehicle, OSU-HDAC42, or SAHA, then assays of cell viability were performed. Histone acetylation was assessed by use of western blot analysis. Apoptosis was assessed via ELISA to detect fragmentation of cytoplasmic nucleosomal DNA and western blot analysis to detect cleavage of caspase 3. Cell cycle analysis was performed by use of propidium iodide staining and flow cytometry. RESULTS-Concentrations of OSU-HDAC42 and SAHA required to achieve 50% inhibition of cell viability (IC(50)) were reached in cells of 6 and 4 canine cancer cell lines, respectively, and ranged from approximately 0.4 to 1.3 microM for OSU-HDAC42 and 0.6 to 4.8 microM for SAHA. Cells from T-cell lymphoma, mast cell tumor, osteosarcoma, and histiocytic sarcoma lines were most sensitive to HDAC inhibition, with IC(50)s of < 1 microM for OSU-HDAC42 and < 5 microM for SAHA. Induction of apoptosis was indicated via cleavage of caspase 3 and increases in cytoplasmic nucleosomes and the subG(1) cell population. CONCLUSIONS AND CLINICAL RELEVANCE: Micromolar concentrations of HDAC inhibitors OSU-HDAC42 and SAHA induced histone acetylation, cytotoxicity, and apoptosis in canine cancer cells. In general, OSU-HDAC42 was more potent than SAHA. 相似文献
8.
Consumption and processing of allochthonous plant litter by fishes is more common in tropical than temperate streams and rivers.
Therefore, aquatic hyphomycetes in water (filtration), leaf litter (bubble chamber incubation), and fecal pellets (direct
observation and inoculation to sterile leaf litter) of three dominant fishes belonging to the family Cyprinidae (Aplocheilus lineatus, Puntius filamentosus, and Rasbora daniconius) in two locations of the River Kali of the Western Ghats, India, were evaluated during postmonsoon season. Spores of 14 and
9 species of aquatic hyphomycetes were recovered on filtering water samples of Kaiga stream and Kadra dam with equal number
of spores (32 spores · 100 mL−1) and high Shannon diversity in Kaiga stream. In a bubble chamber incubation of leaf litter, 16 and 9 species were recovered
from Kaiga stream and Kadra dam with high spore output (1122 versus 324 spores per mg dry mass) and high Shannon diversity
in Kaiga stream. Both direct and indirect methods of examination of fecal pellets of fishes revealed more species in Kaiga
stream than Kadra dam (4–7 versus 1–4 species). The spore release in leaf litter incubated with fecal pellets ranged from
2.3 to 98 spores·mg−1·d−1 with the highest Aplocheilus lineatus in Kaiga stream; while in Kadra dam, it was from 0.02 to 22.9 spores·mg−1·d−1 with the highest in Puntius filamentosus. The Shannon diversity of aquatic hyphomycetes was high in fecal pellets of Aplocheilus lineatus of Kaiga stream and Rasbora daniconius of Kadra dam. The top-ranked five species of aquatic hyphomycetes differed in water, leaf litter, and fish fecal pellets;
however, Triscelophorus konajensis was common for all. All five top-ranked species of aquatic hyphomycetes in feces produced multicelled spores; thus, they
were likely to have a better chance of viability through gut passage than single-celled spores. Preferential feeding, fungi
in gut and feces, and survival and dissemination of spores by invertebrates and fishes with reference to aquatic hyphomycetes
were discussed. 相似文献
9.
Bhaskar Bhagya Kandikere R. Sridhar Sahadevan Seena Chiu-Chung Young Ananthapadmanabha B. Arun 《Frontiers of Agriculture in China》2010,4(4):481-488
This study has been performed to evaluate the nutritional, antinutritional and protein qualities of tender pods of Canavalia maritima, the coastal sand dune wild legume of southwest India. The proximal features, minerals, amino acids, fatty acids, antinutritional
and protein qualities of fresh and pressure-cooked tender pods have been assessed. The crude protein was comparable to seeds
of many edible legumes. Cooking significantly elevated the carbohydrates and calorific value of tender pods (P < 0.05), while crude fiber was significantly decreased (P < 0.05). Minerals of fresh pods did not drain too much on cooking and K, Mg, Zn and Mn in fresh as well as cooked pods were
comparable or higher than the NRC-NAS recommended pattern. Although cooking decreased the essential amino acids, threonine,
valine, isoleucine, phenylalanine and lysine in cooked pods were equivalent or higher than the FAO-WHO-UNU recommended pattern.
The palmitoleic acid in fresh pods and eicosenoic acid in cooked pods were relatively high. Similarly, the essential fatty
acids, linolenic acid and linoleic acid were confined to fresh and cooked pods respectively. The fresh pods were devoid of
tannins and trypsin inhibitors. The total phenolics and hemagglutinin activity decreased substantially in cooked pods. The
diet of pressure-cooked pods showed improvement of in vivo protein quality, elevation of growth parameters and positive nitrogen balance in rats. Overall, the pressurecooking of tender
pods of C. maritima improved the nutritional qualities by lowering the hemagglutinin activity. 相似文献
10.
M.K.C. Sridhar G.O. Adeoye J.A.I. Omueti G. Yinda Z.D. Reece 《Compost science & utilization》2013,21(1):69-74
While some composting had been practiced on a limited basis in Nigeria 50 years ago, the practice still is largely neglected. Farmers find it more convenient to use fertilizers because of the ease of carrying, storing and applying. However, since 1986, there has been a major change in the composition of refuse in Nigeria. With greater numbers of people in the low socioeconomic groups scavenging on the refuse dumps collecting paper, metal, glass and plastics, the remaining refuse is mostly organic and ideal for making compost. Studies undertaken at the University of Ibadan reveal that once mobilized, communities can be effective in launching composting projects. Appropriate technology is favored in processing the wastes rather than extensive and, often unaffordable, mechanization. 相似文献