Summary Acute febrile diseases are characterized by specific and non-specific symptoms. The non-specific responses are presented under the headings: fever, inflammation and pain, experimental models for investigating febrile reactions, haematologic changes, blood biochemical changes, cardiovascular effects, changes in gastric function, and the effects of fever upon pharmacokinetics of drugs. It was the purpose of this review to describe present concepts of thermoregulation and fever, the associated reactions produced by bacterial pyrogens and the mechanisms of these reactions. The available data illustrate, that many questions have not yet been clearly answered. However, the entire field of research involving endogenous substances, such as interleukin-1, is now moving ahead with great speed. Furthermore, there is some evidence which suggests that fever and the associated lower plasma zinc and iron levels act together as a co-ordinated non-specific host defence mechanism. Since experimental fever has a distinct effect upon the pharmacokinetics of drugs, more attention should be given to this aspect. 相似文献
The release of tumor necrosis factor-alpha (TNF-) from cultured bovine alveolar macrophages (BAM) was evaluated following stimulation of BAM with bovine herpesvirus-1 (BHV-1), parainfluenza-3 (PI-3) virus, bovine respiratory syncytial virus (BRSV), Escherichia coli 0111:B4 endotoxin, Pasteurella haemolytica type 1 endotoxin, Pasteurella multocida endotoxin, and virus/endotoxin combinations. A cytotoxic assay system using Georgia bovine kidney cells as targets was used to measure TNF- activity. The cytotoxic activity was neutralized by an anti-human TNF- monoclonal antibody.
Stimulation of BAM with 1 median tissue culture infectious dose (TCID50) of live or ultraviolet (UV)-inactivated PI-3 virus/cell resulted in release of TNF- in significantly (P<0.05) higher amounts than sham-induced BAM. The quantities of TNF- released after live or UV-inactivated BHV-1 or BRSV induction were not significantly higher than sham-induced BAM. E. coli 0111:B4, P. haemolytica type 1 and P. multocida endotoxins stimulated TNF- release in a dose-dependent manner. Sequential exposure of BAM to 1 TCID50 per cell of either live BHV-1, PI-3 virus or BRSV and then 5 μg ml−1 of either E. coli 0111:B4, P. haemolytica type 1 or P. multocida endotoxin caused a significant (P<0.05) reduction in detectable TNF- in seven of nine virus/endotoxin combinations tested, when compared with 5 μg ml−1 of endotoxin alone. Parainfluenza-3 virus/endotoxin combinations stimulated higher TNF- release when compared with other virus/endotoxin combinations. Five out of six test animals had serum-neutralizing antibodies to PI-3 virus, one out of six had serum-neutralizing antibodies to BHV-1, and two out of six had serum-neutralizing antibodies to BRSV, suggesting a possible relationship between serum neutralizing antibodies and TNF- release from in vitro cultivated BAM. 相似文献
Forty-one dairy cows were fed a low (LCa-13 g/d) and a high (HCa-83.5 g/d) calcium ration in the 8 weeks prior to parturition and the effect on the Ca mobilization rate around parturition was studied. Plasma Ca values were stable in the LCa group around parturition. In the older cows of the HCa group a very slight decrease in the mean plasma Ca was observed: 2.58 mmol/l at 12-36 h ante partum decreased to 2.38 mmol/l at parturition. Hypocalcaemia, which commonly occurs around parturition, did not occur in 40 of the cows. A subclinical hypocalcaemia (1.8 mmol/l) occurred in one cow (parity 10) from the HCa group. To assess the efficiency of Ca mobilization, a severe hypocalcaemia (1.0 mmol/l) with clinical signs was induced by means of Na2EDTA infusion (0.90 mmol/min), starting at 10 h post-partum. The older cows in the LCa group required more Na2EDTA than those in the HCa group. Higher urinary hydroxyproline excretion in the week before parturition in the LCa than in the HCa group suggested a higher bone turnover. Plasma PTH levels around parturition were not significantly different between the groups. The amount of colostrum milked out in the first 10 h post-partum did not influence Ca homeostasis around parturition. The results contradict those of many other experiments in which hypocalcaemia was observed in cows ingesting high levels of Ca. It is concluded that the restricted feed intake prepartum possibly had a favourable effect on Ca homeostasis. 相似文献
Experimental and field trials were conducted to evaluate an ELISA for its ability to detect Trichinella-infected domestic swine and to compare ELISA results with muscle-digestion test results. The ELISA used was a commercial double-antibody kit, containing an excretory-secretory antigen, and was evaluated principally for epidemiologic use. Experimentally induced infection in swine (4 groups of 3 pigs each; inoculated with 0, 50, 500 or 5,000 larvae) was detected as early as postinoculation week 4, with seroconversion of all inoculated swine by postinoculation week 8. The rate of seroconversion appeared to be affected by initial larval dose, time after inoculation, and immunocompetence of the individual host. Determination of antibody kinetics generally revealed rapidly increasing antibody titer, followed by its steady decrease in most pigs. Once seropositive, however, all pigs remained seropositive for the duration of the 10-week study. Presence of muscle larvae was confirmed in all infected pigs at termination of the study. We recognize that the experimental conditions may not be truly representative of those under which natural infection develops in pigs; however, the ELISA detected an infected pig with muscle larval density of 0.87 larvae/g of tissue. Results of a field trial (n = 310) indicated no muscle digestion test-positive pigs (35 g of diaphragm muscle digested/pig), but 3 samples tested positive by ELISA for specificity of 99.0%. 相似文献
This paper describes four cats with hyperadrenocorticism. Cat 1 showed polydipsia and polyphagia. Diabetes mellitus was initially diagnosed. As the animal appeared to be insulin resistant, pituitary and adrenocortical function tests were performed and the diagnosis of hyperadrenocorticism was made. Resistance to the high-dose dexamethasone suppression test was noticed in this cat. Pathological examination revealed a pituitary chromophobe adenoma. Cat 2 presented with diabetes mellitus, which was treated with insulin. The animal had a pendulous abdomen and its coat was in a poor condition. The low-dose dexamethasone suppression test demonstrated hyperadrenocorticism. Necropsy findings of pituitary tumour and hyperplasia of the adrenal cortex confirmed the diagnosis. Cat 3 showed clinical abnormalities indicative of hyperadrenocorticism, for instance, muscle weakness, alopecia, multiple abscesses. The diagnosis of hyperadrenocorticism was confirmed by the results of the lowe-dose dexamethasone suppression test. Pathological examination revealed an adrenocortical carcinoma. Cat 4 presented with polydipsia. The cause of this symptom was not found initially. One and a half years later additional symptoms, such as nephritis and polyphagia developed. Hyperadrenocorticism was diagnosed because of a palpable mass cranial to the left kidney. The diagnosis was confirmed by the results of the lowe-dose dexamethasone suppression test and the necropsy findings. 相似文献
An old dog had an expansile lesion affecting the ulnar diaphysis. The lesion had clinical and radiographic features typical of a bone cyst; however, computed X-ray tomography indicated that the lesion had a tissue content incompatible with a true cyst. The histological diagnosis was osteosarcoma. This report emphasises the highly variable radiological appearance of canine osteosarcoma; biopsy is required to establish the diagnosis because the radiological signs may mimic a lesion of different aetiology. 相似文献
Summary The potential for increased productivity of N'Dama cattle in response to small supplementary inputs of proteinaceous by-products
has been shown to be substantial under village husbandry conditions in The Gambia. Young N'Dama bulls were used to compare
sesame cake with cottonseed as sources of supplementary protein during the wet and early dry seasons of 1987. They were fed
0, 40, 80 or 160 g crude protein/day in these forms for four months. Supplementation significantly increased growth rate from
169 g/d in controls to means of 272 and 271 g/d for those given sesame cake and cottonseed respectively; there were no significant
differences among the supplemented groups.
During the four months of the dry season immediately after supplementation ceased all previously supplemented groups grew
significantly more rapidly than the controls (at leastP<0·05), indicating a substantial carry over effect of the supplements. Over this period the mean gain of the groups previously
given sesame cake exceeded that of those that had received cottonseed (217 cf. 158 g/d;P<0·01). The economic benefits of these responses were substantial.
Comparacion de torta de sesamo y de semilla de algodon como fuente suplementaria de proteina para terneros destetos N'Dama
en Gambia
Resumen Se ha demonstrado el potencial para incrementar la productividad del ganado N'Dama, como resquesta a peque?as cantidades de
insumos suplementarios de proteína, bajo condiciones de villorrio en Gambia. Se utilizaron terneros destetos N'Dama par comparar
la torta de sésamo y de semilla de algodón como fuente de proteína suplementaria durate la estaicón lluviosa y principio de
la seca del a?o 1987. Se les dió a los animales 0, 40, 80 o 160 g de proteína cruda/día en éstas formas durante cuatro meses.
La suplementación incrementó significativamente la tasa de crecimiento, de 169 g/día en controles a 272 y 271 g/día en aquellos
que recibieron torta de sésamo y de algodón respectivamente; no hubo diferenca estadística entre los grupos suplementados.
Durate los cuatro meses de la estación seca inmediatamente después de que la suplementación fue suspendida, todos los grupos
que habían sido suplementados crecieron sgnificativamente más rápido que los controls (P<0·05), indicando un efecto compensatorio en los suplementados. Durante ese período la media de crecimento de los grupos que
recibieron torta de sésamo excedió a aquella de los que habían recibido torta de algodón (217 cf. 158 g/d;P<0·01). Los beneficios económicos de estos resultados fueron substanciales.
Comparaison entre le tourteau de sesame et la graine de coton comme sources complementaires de proteines pour les taurillons
N'Dama sevres en Gambie
Résumé Le potentiel de réponse à de petites quantités supplémentaires de sous-produits proteiniques pour accroitre la productivité
de bétail N'Dama, s'est révélé manifeste, dans les conditions d'élevage villageois en Gambie. De jeunes taureaux N'Dama ont
été utilisés pour comparer le tourteau de sésame et la graine de coton en tant que source de complémentation protéinique pendant
la saison sèche et le début de la saison humide au cours de l'année 1987. Ils ont re?u respectivement 0, 40, 80 ou 160 g de
proteines brutes par jour sus ces deux formes pendat quatre mois. Cette supplémentation a accru de fa?on significative le
taux de croissance, de 169 g/jour pour les témoins jusqu'à des moyennes de 272 et 271g/jour respectivement pour ceux qui ont
re?u du tourteau de sésame et de la graine de coton. Quant aux groupes complémentés, il n'ont révélé aucune différence significative.
Pendat les quatre mois de la saison sèche et immédiatement après l'arrêt de la supplémentation, tous les lots ayant fait précédemment
l'objet d'une distribution complémentaire ont eu une croissance significativement plus rapide que les animaux témoins, du
moins pourP<0,05, ce qui indique un effet important de report des suppléments.
Durant cette période, le gain moyen des lots qui ont re?u le tourteau de sésame a dépassé celui des lots auxquels on a donné
de la graine de coton, soit 217 g/jour contre 158 g/jour pourP<0,01. Les profits économiques de ces réponses ont été appréciables.
Chronic osteomyelitis and septic arthritis involving the 3rd and 4th metatarsophalangeal joints were diagnosed in a Doberman Pinscher. Arthrodesis of the 3rd and 4th metatarsophalangeal joints resulted in a subtle persistent gait abnormality, but limb function was preserved. Arthrodesis of metatarsophalangeal joints is an alternative to amputation, especially when main weight-bearing digits are involved. 相似文献