排序方式: 共有20条查询结果,搜索用时 0 毫秒
1.
Carlos LIGHTOWLER Giuseppe PICCIONE Francesco FAZIO Gabriela PIDAL Marìa Laura CATTÁNEO 《Animal Science Journal》2003,74(6):505-510
In the present study, the ‘acoustic windows’ for the measurement of the left ventricular systolic time intervals is studied by means of 2‐D echocardiography and cardiac Doppler ultrasonography, and the normal values in the horse (n = 112) are determined. The left ventricular isovolumetric contraction time, the pre‐ejection period (PEP), as well as the left ventricular ejection time (LVET) have been measured, and the values of the left ventricular total electromechanical systole (LVTES) and the PEP‐to‐LVET ratio have been calculated. It has been established that the most suitable window for the measurement of the aforementioned indices in 2‐D echocardiography is the right parasternal window in a view in short axis at the level of the cardiac base to measure the aortogram. In Doppler ultrasonography, the preferred window is the left parasternal using the five chambers apical view. The following values have been acquired: PEP = 0.071 ± 0.01 s; LVET = 0.532 ± 0.097 s; LVTES = 0.6 ± 0.1 s and PEP‐to‐LVET = 0.138 ± 0.025 measured by 2‐D echocardiography and PEP = 0.068 ± 0.009 s; LVET = 0.527 ± 0.076 s; LVTES = 0.598 ± 0.098 s and PEP‐to‐LVET = 0.131 ± 0.01 measured by Doppler ultrasonography. 相似文献
2.
Hepatic AA amyloidosis in a cat: cytologic and histologic identification of AA amyloid in macrophages 下载免费PDF全文
Sakurako Neo‐suzuki Takayuki Mineshige Junichi Kamiie Hideki Kayanuma Yukako Mochizuki Masaharu Hisasue Ryo Tsuchiya Kinji Shirota 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2017,46(2):331-336
A 3‐year‐old, spayed female, Domestic Shorthair cat presented with anorexia, lethargy, vomiting, probable hemoabdomen, and multiple masses on the right lateral liver lobe. Clinicopathologic and imaging abnormalities included anemia, azotemia, icterus, and hepatomegaly with hypoechoic masses. On cytologic evaluation of a fine‐needle aspiration of a liver mass there was abundant extracellular pink‐ to purple‐colored material between hepatocytes. The amorphous material was stained with direct fast scarlet (DFS), and green birefringent areas were observed under polarized light, confirming the presence of amyloid. A unique finding on the cytologic smear were macrophages containing amorphous and fibrillar amyloid‐like protein. Histopathologic examination using H&E and Congo red staining confirmed amyloid deposits within the space of Disse, along the sinusoids, portal tracts, blood vessel walls, and within the cytoplasm of macrophages. Immunohistochemical staining with anti‐AA amyloid antibodies further confirmed the presence of AA amyloid. To the author's knowledge, this is the first report of the cytologic finding of AA amyloid protein within macrophages and DFS stain detection of amyloid on a cytologic smear. 相似文献
3.
Masaharu HISASUE Mina TANAKA Sakurako NEO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(1):142
A 5-year-old female cat with nonregenerative anemia and thrombocytopenia was diagnosed with myelodysplastic syndromes (MDS), since peripheral blood and bone marrow (BM) examination revealed various dysplasias and a blast ratio of 19%. Chemotherapy with azacytidine (AZA; 70–35 mg/m2, 3–5 days, three cycles) and treatment with prednisolone, antibiotics, and vitamin K2, and blood transfusion were performed. On day 106, blast cells and dysplasia had decreased in the BM, and the cat remained alive for at least 1,474 days. This report is the first on feline MDS treated with AZA, suggesting appropriate drug dosage, interval and effective combination should be investigated and the pharmacological and cell biological mechanisms needs to be elucidated in the future. 相似文献
4.
Takuma AOKI Hiroshi SUNAHARA Keisuke SUGIMOTO Tetsuro ITO Eiichi KANAI Sakurako NEO Yoko FUJII Yoshito WAKAO 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(9):1187-1190
Dynamic left ventricular outflow tract obstruction (DLVOTO) is a common condition in cats
and humans. In this case report, a dog is described with DLVOTO secondary to severe
intra-abdominal hemorrhage caused by a hemangiosarcoma. The dog was a 9-year-old, 35.7-kg,
spayed female German Shepard dog that presented with a history of tachypnea and collapse.
A Levine II/VI systolic murmur was present at the heart base. Abdominal ultrasonography
revealed a splenic mass and a large amount of ascites. Echocardiography showed a reduced
left ventricular diameter and an increased aortic velocity caused by systolic anterior
motion (SAM) of the mitral valve apparatus. The heart murmur and the SAM were resolved
after treatment including a splenectomy and a blood transfusion. 相似文献
5.
Satoshi Kitao Takatsugu Yamada Takefumi Ishikawa Hiroo Madarame Mitsuru Furuichi Sakurako Neo Ryo Tsuchiya Kosaku Kobayashi 《Journal of veterinary diagnostic investigation》2006,18(3):291-295
Serum alpha-fetoprotein (AFP) concentrations were measured before and after surgical removal of tumor masses in four dogs with hepatocellular carcinoma (HCC). Localization of AFP was also examined immunohistochemically in tumor tissues. In three cases, the serum AFP concentration was 10 to 20 times higher than that of normal dogs. One to two months after surgery, the serum AFP concentration had decreased to normal range. AFP was localized in the tumor tissues in these three cases. One case, which had a low serum AFP, did not show AFP localization in tumor tissue. 相似文献
6.
Makoto Akiyoshi Masaharu Hisasue Sakurako Neo Masami Akiyoshi 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2021,50(1):151-157
A 12‐year‐old spayed female Shiba Inu dog was referred to our hospital for a suspected mast cell tumor (MCT) of the bone marrow (BM). Laboratory abnormalities included severe nonregenerative anemia (packed cell volume or PCV: 12.5%; reference interval (RI): 37.3‐61.7%; reticulocytes: 35.1 × 103/µL; RI: 10‐110 × 103/µL), and a few mast cells were visualized in the blood smear examination. The BM was hypercellular with hematopoietic cells, a decreased myeloid:erythroid (M:E) ratio (0.77; RI, 0.9‐1.8), and no dysplastic hematopoietic cells. Mast cells accounted for 11.5% of the total nucleated BM cells. Neoplastic mast cells and histiocytes phagocytizing erythroid progenitor cells were occasionally noted. The dog was diagnosed with precursor‐targeted immune‐mediated anemia (PIMA) concurrent and a stage IV MCT infiltrating the BM. Multimodal treatment included toceranib, imatinib, vinblastine, lomustine (CCNU), prednisolone, cyclosporine, mycophenolate mofetil, and a blood transfusion. The dog died due to MCT progression lasting 139 days after the initial BM examination. To the best of our knowledge, this is the first report of a dog presenting with PIMA and a stage IV MCT infiltrating the BM. 相似文献
7.
Makoto AKIYOSHI Masaharu HISASUE Sakurako NEO Masami AKIYOSHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(4):689
This report describes the cases of two Miniature Dachshunds who were suspected to have immune-mediated hemolytic anemia (IMHA) and were treated with immunosuppressive therapy. However, progression of anemia, increases in C-reactive protein (CRP) and total-bilirubin (T-Bil) levels, splenomegaly, transition to nonregenerative anemia, and thrombocytopenia occurred after the treatment. Splenectomy and bone-marrow aspirations were performed subsequently. Both dogs were diagnosed with hemophagocytic syndrome (HPS) associated with IMHA. Unfortunately, they died 9 and 6 days later. These findings indicate that some cases of refractory IMHA have the pathogenicity of HPS. HPS should be included as a differential diagnosis of refractory IMHA concurrent with thrombocytopenia. Continuously elevated CRP and T-Bil levels may be helpful indicators in the detection of HPS associated with IMHA. 相似文献
8.
Molecular cloning of the canine c-Met/HGF receptor and its expression in normal and regenerated liver 总被引:4,自引:0,他引:4
Neo S Kansaku N Furuichi M Watanabe M Hisamatsu S Ohno K Hisasue M Tsuchiya R Yamada T 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2005,67(5):525-529
The c-Met proto-oncogene is the receptor for hepatocyte growth factor (HGF), which is a member of the tyrosine kinase family. Activation of the HGF/c-Met signal pathway leads to cell proliferation, motility, regeneration, and morphogenesis. In this study, the complete nucleotide sequence of complementary DNA (cDNA) of canine c-Met was cloned, and its distribution was determined in tissues. The canine c-Met cDNA clone had an open reading frame of 4419 bp that encoded a putative polypeptide of 1383 amino acids. The c-Met mRNA was expressed in a variety of canine tissues including peripheral blood mononuclear cells (PBMC), bone marrow, liver, kidney, lung, stomach, uterus, testis, thymus, lymph node, small intestine, colon, adrenal gland, thyroid gland, heart, muscle, skin, pancreas, ovary, prostate, spleen, fat, cerebrum, and cerebellum. In addition, the c-Met mRNA expression in normal and regenerated liver was examined. The levels of the mRNA increased 2-fold in regenerated liver compared to that found in normal liver, indicating that c-Met is involved in various functions including remodeling of canine hepatocytes. 相似文献
9.
Sakurako NEO Iyo TAKEMURA-UCHIYAMA Jumpei UCHIYAMA Hironobu MURAKAMI Ayaka SHIMA Hideki KAYANUMA Taiki YOKOYAMA Satoshi TAKAGI Eiichi KANAI Masaharu HISASUE 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(7):1019
Although the biliary system is generally aseptic, gallbladder microbiota has been reported in humans and some animals apart from dogs. We screened and analyzed the bacterial deoxyribonucleic acid in canine gallbladders using bile sampled from 7 healthy dogs and 52 dogs with liver- or gallbladder-associated disease. PCR screening detected bacteria in 17.3% of diseased dogs (9/52) and none in healthy dogs. Microbiota analysis of PCR-positive samples showed that the microbial diversity differed between liver- and gallbladder-associated disease groups. Thus, a specific bacterial community appears to occur at a certain frequency in the bile of diseased dogs. 相似文献
10.
Tatsuro Hirose Sakurako Kadoya Yoichi Hashida Masaki Okamura Ryu Ohsugi 《Plant Production Science》2017,20(1):90-94
Tachisuzuka, a rice cultivar grown for whole-crop silage, is characterized by the small-panicle trait and high-stem sugar content. To investigate the interrelationship between the two features, we attempted to identify the gene responsible for the small-panicle trait in Tachisuzuka, and also to examine the function of the gene using a knockout mutant line. A functionally disruptive deletion of the nucleotide sequence was found in the gene SP1 (Short-Panicle 1; Os11g0235200) in Tachisuzuka, which has been reported as a candidate gene for the small-panicle trait. A gene knockout mutant of SP1 obtained from the cultivar Nipponbare showed a small-panicle phenotype similar to that observed in Tachisuzuka. However, soluble sugar content in the stem did not increase in the knockout line, whereas starch content increased significantly. Overall, disruption of SP1 is responsible for the small-panicle phenotype of Tachisuzuka, but it is only partially associated with the high-stem sugar content. 相似文献