Efficacy of a trivalent inactivated vaccine against bluetongue in both cattle and small ruminants

The paper presents the results of testing an inactivated trivalent vaccine against bluetongue virus of serotypes 1, 6, and 8 in calves, sheep, and goats. After the vaccine was inoculated, the dynamics of animal blood indices and biochemical parameters of both experimental and control groups were within the range of physiological standards. It has been proven that the sorbed and inactivated emulsified vaccines could protect calves from infection with a virulent virus of a homologous serotype and could be used for immunizing both cattle and small ruminants.     

Effects of the long-term addition of sucrose and of the presence of ectomycorrhizal roots on the functioning of microbal communities in soddy-podzolic soil

A field experiment showed that long-term addition of easily accessible carbon (sucrose) into soil leads to an abrupt reduction in the number of cellulose-degrading bacteria but to an increase in the functional diversity of the soil microbial community along with an increase in carbon dioxide emission, nitrogen fixation, and denitrification. The exclusion of ectomycorrhizal spruce roots did not affect the number of hydrolytic bacteria but stimulated nitrogen fixation and decreased the intensity of basal respiration and denitrification activity of the soil.     

Combinatorial synthesis of peptide arrays onto a microchip

Arrays promise to advance biology through parallel screening for binding partners. We show the combinatorial in situ synthesis of 40,000 peptide spots per square centimeter on a microchip. Our variant Merrifield synthesis immobilizes activated amino acids as monomers within particles, which are successively attracted by electric fields generated on each pixel electrode of the chip. With all different amino acids addressed, particles are melted at once to initiate coupling. Repetitive coupling cycles should allow for the translation of whole proteomes into arrays of overlapping peptides that could be used for proteome research and antibody profiling.     

The novel pyridazine pyrazolecarboxamide insecticide dimpropyridaz inhibits chordotonal organ function upstream of TRPV channels

The cover image is based on the Research Article The novel pyridazine pyrazolecarboxamide insecticide dimpropyridaz inhibits chordotonal organ function upstream of TRPV channels by Christian Spalthoff et al., https://doi.org/10.1002/ps.7352